Reaction catalyzed by 11beta-hydroxysteroid dehydrogenase (1.1.1.146)
+
NADP+
=
+
NADPH
+
11beta,21-dihydroxypregn-4-en-3,20-dione
+
NADP+
=
21-hydroxy-pregn-4-en-3,11,20-trione
+
NADPH
+
H+
