Reaction catalyzed by 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (2.1.1.116)

		+			=			+
	S-adenosyl-L-methionine	+		3'-hydroxy-N-methyl-(S)-coclaurine	=		S-adenosyl-L-homocysteine	+		(S)-reticuline