Sequence of KMO_PSEFL
EC Number:1.14.13.9
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O
Other sequences found for EC No. 1.14.13.9
General information:
Sequence
0 MTATDNARQV TIIGAGLAGT LVARLLARNG WQVNLFERRP DPRIETGARG RSINLALAER
60 GAHALRLAGL EREVLAEAVM MRGRMVHVPG TPPNLQPYGR DDSEVIWSIN RDRLNRILLD
120 GAEAAGASIH FNLGLDSVDF ARQRLTLSNV SGERLEKRFH LLIGADGCNS AVRQAMASVV
180 DLGEHLETQP HGYKELQITP EASAQFNLEP NALHIWPHGD YMCIALPNLD RSFTVTLFLH
240 HQSPAAQPAS PCFAQLVDGH AARRFFQRQF PDLSPMLDSL EQDFEHHPTG KLATLRLTTW
300 HVGGQAVLLG DAAHPMVPFH GQGMNCALED AVALAEHLQS AADNASALAA FTAQRQPDAL
360 AIQAMALENY VEMSSKVASP TYLLERELGQ IMAQRQPTRF IPRYSMVTFS RLPYAQAMAR
420 GQIQEQLLKF AVANHSDLTS INLDAVEHEV TRCLPPLSHL C
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
435361
Matthijs S.,Baysse C.,Koedam N.,Tehrani K.A.,Verheyden L.,Budzikiewicz H.,Schaefer M.,Hoorelbeke B.,Meyer J.-M.,De Greve H.,Cornelis P.
The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway.
Mol. Microbiol.
52
371-384
2004
435362
Crozier K.R.,Moran G.R.
Heterologous expression and purification of kynurenine-3-monooxygenase from Pseudomonas fluorescens strain 17400.
Protein Expr. Purif.
51
324-333
2007
435363
Mole D.J.,Webster S.P.,Uings I.,Zheng X.,Binnie M.,Wilson K.,Hutchinson J.P.,Mirguet O.,Walker A.,Beaufils B.,Ancellin N.,Trottet L.,Beneton V.,Mowat C.G.,Wilkinson M.,Rowland P.,Haslam C.,McBride A.,Homer N.Z.,Baily J.E.,Sharp M.G.,Garden O.J.,Hughes J.,Howie S.E.,Holmes D.S.,Liddle J.,Iredale J.P.
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.
Nat. Med.
22
202-209
2016
435364
Liddle J.,Beaufils B.,Binnie M.,Bouillot A.,Denis A.A.,Hann M.M.,Haslam C.P.,Holmes D.S.,Hutchinson J.P.,Kranz M.,McBride A.,Mirguet O.,Mole D.J.,Mowat C.G.,Pal S.,Rowland P.,Trottet L.,Uings I.J.,Walker A.L.,Webster S.P.
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
Bioorg. Med. Chem. Lett.
27
2023-2028
2017
435365
Walker A.L.,Ancellin N.,Beaufils B.,Bergeal M.,Binnie M.,Bouillot A.,Clapham D.,Denis A.,Haslam C.P.,Holmes D.S.,Hutchinson J.P.,Liddle J.,McBride A.,Mirguet O.,Mowat C.G.,Rowland P.,Tiberghien N.,Trottet L.,Uings I.,Webster S.P.,Zheng X.,Mole D.J.
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
J. Med. Chem.
60
3383-3404
2017
435366
Hutchinson J.P.,Rowland P.,Taylor M.R.D.,Christodoulou E.M.,Haslam C.,Hobbs C.I.,Holmes D.S.,Homes P.,Liddle J.,Mole D.J.,Uings I.,Walker A.L.,Webster S.P.,Mowat C.G.,Chung C.W.
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat. Commun.
8
15827-15827
2017
435367
Kim H.T.,Na B.K.,Chung J.,Kim S.,Kwon S.K.,Cha H.,Son J.,Cho J.M.,Hwang K.Y.
Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase.
Cell Chem. Biol.
0
0-0
2018
435368
Gao J.,Yao L.,Xia T.,Liao X.,Zhu D.,Xiang Y.
Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.
FASEB J.
32
2036-2045
2018
