Sequence of IDHP_PIG
EC Number:1.1.1.42
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
Other sequences found for EC No. 1.1.1.42
General information:
Sequence
0 ARAAARHYAD QRIKVAKPVV EMDGDEMTRI IWQFIKEKLI LPHVDVQLKY FDLGLPNRDQ
60 TNDQVTIDSA LATQKYSVAV KCATITPDEA RVEEFKLKKM WKSPNGTIRN ILGGTVFREP
120 IICKNIPRLV PGWTKPITIG RHAHGDQYKA TDFVVDRAGT FKIVFTPKDG SSAKQWEVYN
180 FPAGGVGMGM YNTDESISGF AHSCFQYAIQ KKWPLYMSTK NTILKAYDGR FKDIFQEIFE
240 KHYKTDFDKY KIWYEHRLID DMVAQVLKSS GGFVWACKNY DGDVQSDILA QGFGSLGLMT
300 SVLVCPDGKT IEAEAAHGTV TRHYREHQKG RPTSTNPIAS IFAWTRGLEH RGKLDGNQDL
360 IRFAQTLEKV CVETVESGAM TKDLAGCIHG LSNVKLNEHF LNTSDFLDTI KSNLDRALGR
420 Q
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
430508
Haselbeck R.J.,Colman R.F.,McAlister-Henn L.
Isolation and sequence of a cDNA encoding porcine mitochondrial NADP-specific isocitrate dehydrogenase.
Biochemistry
31
6219-6223
1992
430509
Smyth G.E.,Colman R.F.
Cysteinyl peptides of pig heart NADP-dependent isocitrate dehydrogenase that are modified upon inactivation by N-ethylmaleimide.
J. Biol. Chem.
266
14918-14925
1991
430510
Ehrlich R.S.,Colman R.F.
Characterization of an active site peptide modified by the substrate analogue 3-bromo-2-ketoglutarate on a single chain of dimeric NADP+-dependent isocitrate dehydrogenase.
J. Biol. Chem.
262
12614-12619
1987
430511
Kim T.K.,Lee P.,Colman R.F.
Critical role of Lys212 and Tyr140 in porcine NADP-dependent isocitrate dehydrogenase.
J. Biol. Chem.
278
49323-49331
2003
430512
Ceccarelli C.,Grodsky N.B.,Ariyaratne N.,Colman R.F.,Bahnson B.J.
Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism.
J. Biol. Chem.
277
43454-43462
2002
