Sequence of DPGA_AMYBA
EC Number:2.3.1.246
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
4 malonyl-CoA = (3,5-dihydroxyphenylacetyl)-CoA + 3 CoA + 4 CO2 + H2O
Other sequences found for EC No. 2.3.1.246
General information:
Sequence
0 MGVDVSMTTS IEPAEDLSVL SGLTEITRFA GVGTAVSASS YSQSEVLDIL DVEDPKIRSV
60 FLNSAIDRRF LTLPPESPGG GRVSEPQGDL LDKHKELAVD MGCRALEACL KSAGATLSDL
120 RHLCCVTSTG FLTPGLSALI IRELGIDPHC SRSDIVGMGC NAGLNALNVV AGWSAAHPGE
180 LGVVLCSEAC SAAYALDGTM RTAVVNSLFG DGSAALAVIS GDGRVPGPRV LKFASYIITD
240 ALDAMRYDWD RDQDRFSFFL DPQIPYVVGA HAEIVADRLL SGTGLRRSDI GHWLVHSGGK
300 KVIDSVVVNL GLSRHDVRHT TGVLRDYGNL SSGSFLFSYE RLAEEGVTRP GDYGVLMTMG
360 PGSTIEMALI QW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
411007
Pelzer S.,Sussmuth R.,Heckmann D.,Recktenwald J.,Huber P.,Jung G.,Wohlleben W.
Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.
Antimicrob. Agents Chemother.
43
1565-1573
1999
411008
Bischoff D.,Pelzer S.,Bister B.,Nicholson G.J.,Stockert S.,Schirle M.,Wohlleben W.,Jung G.,Suessmuth R.D.
The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.
Angew. Chem. Int. Ed. Engl.
40
4688-4691
2001
411009
Pfeifer V.,Nicholson G.J.,Ries J.,Recktenwald J.,Schefer A.B.,Shawky R.M.,Schroeder J.,Wohlleben W.,Pelzer S.
A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.
J. Biol. Chem.
276
38370-38377
2001
411010
Puk O.,Huber P.,Bischoff D.,Recktenwald J.,Jung G.,Suessmuth R.D.,van Pee K.H.,Wohlleben W.,Pelzer S.
Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.
Chem. Biol.
9
225-235
2002
411011
Recktenwald J.,Shawky R.M.,Puk O.,Pfennig F.,Keller U.,Wohlleben W.,Pelzer S.
Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.
Microbiology
148
1105-1118
2002
411012
Tseng C.C.,McLoughlin S.M.,Kelleher N.L.,Walsh C.T.
Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase.
Biochemistry
43
970-980
2004
