Sequence of SGCC_STRGL
EC Number:1.14.14.15
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase
Q8GMG6
Streptomyces globisporus
527
58255
Reaction
(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] + FAD + H2O
Other sequences found for EC No. 1.14.14.15
General information:
Sequence
0 MPHGAEREAS PAEESAGTRP LTGEEYLESL RDAREVYLDG SRVKDVTAHP AFHNPARMTA
60 RLYDSLHDPA QKAVLTAPTD AGDGFTHRFF TAPRSVDDLV KDQAAIASWA RKSYGWMGRS
120 PDYKASFLGT LGANADFYEP FADNARRWYR ESQEKVLYWN HAFLHPPVDR SLPADEVGDV
180 FIHVERETDA GLVVSGAKVV ATGSALTHAA FISHWGLPIK DRKFALVATV PMDADGLKVI
240 CRPSYSANAA TTGSPFDNPL SSRLDENDAI LVLDQVLIPW ENVFVYGNLG KVHLLAGQSG
300 MIERATFHGC TRLAVKLEFI AGLLAKALDI TGAKDFRGVQ TRLGEVLAWR NLFWSLSDAA
360 ARNPVPWKNG TLLPNPQAGM AYRWFMQIGY PRVLEIVQQD VASGLMYVNS STEDFRNPET
420 GPYLEKYLRG SDGAGAVERV KVMKLLWDAV GSDFGGRHEL YERNYSGNHE NTRIELLLSQ
480 TASGKLDSYM DFAQACMDEY DLDGWTAPDL ESFHAMRSAS RDLLGGL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
358208
Liu W.,Christenson S.D.,Standage S.,Shen B.
Biosynthesis of the enediyne antitumor antibiotic C-1027.
Science
297
1170-1173
2002
358209
Lin S.,Van Lanen S.G.,Shen B.
Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.
J. Am. Chem. Soc.
130
6616-6623
2008
358210
Chang C.Y.,Lohman J.R.,Cao H.,Tan K.,Rudolf J.D.,Ma M.,Xu W.,Bingman C.A.,Yennamalli R.M.,Bigelow L.,Babnigg G.,Yan X.,Joachimiak A.,Phillips G.N.,Shen B.
Crystal structures of SgcE6 and SgcC, the two-component monooxygenase that catalyzes hydroxylation of a carrier protein-tethered substrate during the biosynthesis of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus.
Biochemistry
55
5142-5154
2016
