Sequence of KLK7_HUMAN
EC Number:3.4.21.117
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
cleavage of proteins with aromatic side chains in the P1 position
Other sequences found for EC No. 3.4.21.117
General information:
Sequence
0 MARSLLLPLQ ILLLSLALET AGEEAQGDKI IDGAPCARGS HPWQVALLSG NQLHCGGVLV
60 NERWVLTAAH CKMNEYTVHL GSDTLGDRRA QRIKASKSFR HPGYSTQTHV NDLMLVKLNS
120 QARLSSMVKK VRLPSRCEPP GTTCTVSGWG TTTSPDVTFP SDLMCVDVKL ISPQDCTKVY
180 KDLLENSMLC AGIPDSKKNA CNGDSGGPLV CRGTLQGLVS WGTFPCGQPN DPGVYTQVCK
240 FTKWINDTMK KHR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
310831
Hansson L.,Stroemqvist M.,Baeckman A.,Wallbrandt P.,Carlstein A.,Egelrud T.
Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.
J. Biol. Chem.
269
19420-19426
1994
310832
Yousef G.M.,Scorilas A.,Magklara A.,Soosaipillai A.,Diamandis E.P.
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation.
Gene
254
119-128
2000
310833
Gan L.,Lee I.,Smith R.,Argonza-Barrett R.,Lei H.,McCuaig J.,Moss P.,Paeper B.,Wang K.
Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.
Gene
257
119-130
2000
310834
Hansson L.,Backman A.,Ny A.,Edlund M.,Ekholm E.,Ekstrand Hammarstrom B.,Tornell J.,Wallbrandt P.,Wennbo H.,Egelrud T.
Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.
J. Invest. Dermatol.
118
444-449
2002
310835
Dong Y.,Kaushal A.,Brattsand M.,Nicklin J.,Clements J.A.
Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers.
Clin. Cancer Res.
9
1710-1720
2003
310837
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
310839
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
310840
Skytt A.,Stroemqvist M.,Egelrud T.
Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme.
Biochem. Biophys. Res. Commun.
211
586-589
1995
310841
Heiker J.T.,Kloting N.,Kovacs P.,Kuettner E.B.,Strater N.,Schultz S.,Kern M.,Stumvoll M.,Bluher M.,Beck-Sickinger A.G.
Vaspin inhibits kallikrein 7 by serpin mechanism.
Cell. Mol. Life Sci.
70
2569-2583
2013
310842
Debela M.,Hess P.,Magdolen V.,Schechter N.M.,Steiner T.,Huber R.,Bode W.,Goettig P.
Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.
Proc. Natl. Acad. Sci. U.S.A.
104
16086-16091
2007
310843
Fernandez I.S.,Standker L.,Magert H.J.,Forssmann W.G.,Gimenez-Gallego G.,Romero A.
Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6).
J. Mol. Biol.
377
1488-1497
2008
