Sequence of COBU_SALTY
EC Number:2.7.7.62
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
adenosylcobinamide-phosphate guanylyltransferase
Q05599
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
181
19902
Reaction
GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP
Other sequences found for EC No. 2.7.7.62
General information:
Sequence
0 MMILVTGGAR SGKSRHAEAL IGDAPQVLYI ATSQILDDEM AARIQHHKDG RPAHWRTAEC
60 WRHLDTLITA DLAPDDAILL ECITTMVTNL LFALGGENDP EQWDYAAMER AIDDEIQILI
120 AACQRCPAKV VLVTNEVGMG IVPENRLARH FRDIAGRVNQ RLAAAADEVW LVVSGIGVKI
180 K
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
278431
Roth J.R.,Lawrence J.G.,Rubenfield M.,Kieffer-Higgins S.,Church G.M.
Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium.
J. Bacteriol.
175
3303-3316
1993
278432
McClelland M.,Sanderson K.E.,Spieth J.,Clifton S.W.,Latreille P.,Courtney L.,Porwollik S.,Ali J.,Dante M.,Du F.,Hou S.,Layman D.,Leonard S.,Nguyen C.,Scott K.,Holmes A.,Grewal N.,Mulvaney E.,Ryan E.,Sun H.,Florea L.,Miller W.,Stoneking T.,Nhan M.,Waterston R.,Wilson R.K.
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.
Nature
413
852-856
2001
278433
O'Toole G.A.,Escalante-Semerena J.C.
Purification and characterization of the bifunctional CobU enzyme of Salmonella typhimurium LT2. Evidence for a CobU-GMP intermediate.
J. Biol. Chem.
270
23560-23569
1995
278434
Thomas M.G.,Thompson T.B.,Rayment I.,Escalante-Semerena J.C.
Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation.
J. Biol. Chem.
275
27576-27586
2000
278435
Thompson T.B.,Thomas M.G.,Escalante-Semerena J.C.,Rayment I.
Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3-A resolution.
Biochemistry
37
7686-7695
1998
278436
Thompson T.B.,Thomas M.G.,Escalante-Semerena J.C.,Rayment I.
Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site.
Biochemistry
38
12995-13005
1999
