Sequence of PGTB1_YEAST
EC Number:2.5.1.59
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
protein geranylgeranyltransferase type I
P18898
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
376
42690
Reaction
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
Other sequences found for EC No. 2.5.1.59
General information:
Sequence
0 MCQATNGPSR VVTKKHRKFF ERHLQLLPSS HQGHDVNRMA IIFYSISGLS IFDVNVSAKY
60 GDHLGWMRKH YIKTVLDDTE NTVISGFVGS LVMNIPHATT INLPNTLFAL LSMIMLRDYE
120 YFETILDKRS LARFVSKCQR PDRGSFVSCL DYKTNCGSSV DSDDLRFCYI AVAILYICGC
180 RSKEDFDEYI DTEKLLGYIM SQQCYNGAFG AHNEPHSGYT SCALSTLALL SSLEKLSDKF
240 KEDTITWLLH RQVSSHGCMK FESELNASYD QSDDGGFQGR ENKFADTCYA FWCLNSLHLL
300 TKDWKMLCQT ELVTNYLLDR TQKTLTGGFS KNDEEDADLY HSCLGSAALA LIEGKFNGEL
360 CIPQEIFNDF SKRCCF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
204649
Johnson D.I.,O'Brien J.M.,Jacobs C.W.
Isolation and sequence analysis of CDC43, a gene involved in the control of cell polarity in Saccharomyces cerevisiae.
Gene
90
93-98
1990
204650
Johnson D.I.,O'Brien J.M.,Jacobs C.W.
Isolation and sequence analysis of CDC43, a gene involved in the control of cell polarity in Saccharomyces cerevisiae.
Gene
98
149-150
1991
204651
Ohya Y.,Goebl M.,Goodman L.E.,Petersen-Bjoern S.,Friesen J.D.,Tamanoi F.,Anraku Y.
Yeast CAL1 is a structural and functional homologue to the DPR1 (RAM) gene involved in ras processing.
J. Biol. Chem.
266
12356-12360
1991
204652
James C.M.,Indge K.J.,Oliver S.G.
DNA sequence analysis of a 35 kb segment from Saccharomyces cerevisiae chromosome VII reveals 19 open reading frames including RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43.
Yeast
11
1413-1419
1995
204653
Tettelin H.,Agostoni-Carbone M.L.,Albermann K.,Albers M.,Arroyo J.,Backes U.,Barreiros T.,Bertani I.,Bjourson A.J.,Brueckner M.,Bruschi C.V.,Carignani G.,Castagnoli L.,Cerdan E.,Clemente M.L.,Coblenz A.,Coglievina M.,Coissac E.,Defoor E.,Del Bino S.,Delius H.,Delneri D.,de Wergifosse P.,Dujon B.,Durand P.,Entian K.-D.,Eraso P.,Escribano V.,Fabiani L.,Fartmann B.,Feroli F.,Feuermann M.,Frontali L.,Garcia-Gonzalez M.,Garcia-Saez M.I.,Goffeau A.,Guerreiro P.,Hani J.,Hansen M.,Hebling U.,Hernandez K.,Heumann K.,Hilger F.,Hofmann B.,Indge K.J.,James C.M.,Klima R.,Koetter P.,Kramer B.,Kramer W.,Lauquin G.,Leuther H.,Louis E.J.,Maillier E.,Marconi A.,Martegani E.,Mazon M.J.,Mazzoni C.,McReynolds A.D.K.,Melchioretto P.,Mewes H.-W.,Minenkova O.,Mueller-Auer S.,Nawrocki A.,Netter P.,Neu R.,Nombela C.,Oliver S.G.,Panzeri L.,Paoluzi S.,Plevani P.,Portetelle D.,Portillo F.,Potier S.,Purnelle B.,Rieger M.,Riles L.,Rinaldi T.,Robben J.,Rodrigues-Pousada C.,Rodriguez-Belmonte E.,Rodriguez-Torres A.M.,Rose M.,Ruzzi M.,Saliola M.,Sanchez-Perez M.,Schaefer B.,Schaefer M.,Scharfe M.,Schmidheini T.,Schreer A.,Skala J.,Souciet J.-L.,Steensma H.Y.,Talla E.,Thierry A.,Vandenbol M.,van der Aart Q.J.M.,Van Dyck L.,Vanoni M.,Verhasselt P.,Voet M.,Volckaert G.,Wambutt R.,Watson M.D.,Weber N.,Wedler E.,Wedler H.,Wipfli P.,Wolf K.,Wright L.F.,Zaccaria P.,Zimmermann M.,Zollner A.,Kleine K.
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
Nature
387
81-84
1997
204654
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
204655
Ohya Y.,Ohsumi Y.,Anraku Y.
Genetic study of the role of calcium ions in the cell division cycle of Saccharomyces cerevisiae: a calcium-dependent mutant and its trifluoperazine-dependent pseudorevertants.
Mol. Gen. Genet.
193
389-394
1984
204656
Kohl N.E.,Diehl R.E.,Schaber M.D.,Rands E.,Soderman D.D.,He B.,Moores S.L.,Pompliano D.L.,Ferro-Novick S.,Powers S.,Thomas K.A.,Gibbs J.B.
Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases.
J. Biol. Chem.
266
18884-18888
1991
204657
Finegold A.A.,Johnson D.I.,Farnsworth C.C.,Gelb M.H.,Judd S.R.,Glomset J.A.,Tamanoi F.
Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product.
Proc. Natl. Acad. Sci. U.S.A.
88
4448-4452
1991
204658
Mayer M.L.,Caplin B.E.,Marshall M.S.
CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase.
J. Biol. Chem.
267
20589-20593
1992
204660
Omer C.A.,Kral A.M.,Diehl R.E.,Prendergast G.C.,Powers S.,Allen C.M.,Gibbs J.B.,Kohl N.E.
Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.
Biochemistry
32
5167-5176
1993
204661
Stirtan W.G.,Poulter C.D.
Yeast protein geranylgeranyltransferase type-I: overproduction, purification, and characterization.
Arch. Biochem. Biophys.
321
182-190
1995
204662
Ohya Y.,Caplin B.E.,Qadota H.,Tibbetts M.F.,Anraku Y.,Pringle J.R.,Marshall M.S.
Mutational analysis of the beta-subunit of yeast geranylgeranyl transferase I.
Mol. Gen. Genet.
252
1-10
1996
204663
Stirtan W.G.,Poulter C.D.
Yeast protein geranylgeranyltransferase type-I: steady-state kinetics and substrate binding.
Biochemistry
36
4552-4557
1997
204664
Kim H.,Yang C.H.
Active site determination of yeast geranylgeranyl protein transferase type I expressed in Escherichia coli.
Eur. J. Biochem.
265
105-111
1999
204665
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
204666
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
