Sequence of VM3E_ECHCA
EC Number:3.4.21.60
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
selective cleavage of Arg-/-Thr and Arg-/-Ile in prothrombin to form thrombin and two inactive fragments
Other sequences found for EC No. 3.4.21.60
General information:
Sequence
0 MIQILLVIIC LAVFPYQGCS IILGSGNVND YEVVYPQKVT ALPKGAVQQP EQKYEDAMQY
60 EFEVKGEPVV LHLEKNKELF SEDYSETHYS SDDREITTNP SVEDHCYYHG RIQNDAESTA
120 SISACNGLKG HFKLRGETYF IEPLKIPDSE AHAVYKYENI ENEDEAPKMC GVTQDNWESD
180 EPIKKTLGLI VPPHERKFEK KFIELVVVVD HSMVTKYNND STAIRTWIYE MLNTVNEIYL
240 PFNIRVALVG LEFWCNGDLI NVTSTADDTL HSFGEWRASD LLNRKRHDHA QLLTNVTLDH
300 STLGITFVYG MCKSDRSVEL ILDYSNITFN MAYIIAHEMG HSLGMLHDTK FCTCGAKPCI
360 MFGKESIPPP KEFSSCSYDQ YNKYLLKYNP KCILDPPLRK DIASPAVCGN EIWEEGEECD
420 CGSPADCRNP CCDAATCKLK PGAECGNGEC CDKCKIRKAG TECRPARDDC DVAEHCTGQS
480 AECPRNEFQR NGQPCLNNSG YCYNGDCPIM LNQCIALFSP SATVAQDSCF QRNLQGSYYG
540 YCTKEIGYYG KRFPCAPQDV KCGRLYCLDN SFKKNMRCKN DYSYADENKG IVEPGTKCED
600 GKVCINRKCV DVNTAY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1272685
Nishida S.,Fujita T.,Kohno N.,Atoda H.,Morita T.,Takeya H.,Kido I.,Paine M.J.I.,Kawabata S.,Iwanaga S.
cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom.
Biochemistry
34
1771-1778
1995
1272686
Morita T.,Iwanaga S.,Suzuki T.
The mechanism of activation of bovine prothrombin by an activator isolated from Echis carinatus venom and characterization of the new active intermediates.
J. Biochem.
79
1089-1108
1976
1272687
Kini R.M.
The intriguing world of prothrombin activators from snake venom.
Toxicon
45
1133-1145
2005
