Sequence of UBR1_HUMAN

Carboxypeptidase U

Q8IWV7

1749

200211

751534

Kwak K.S.,Zhou X.,Solomon V.,Baracos V.E.,Davis J.,Bannon A.W.,Boyle W.J.,Lacey D.L.,Han H.Q.

Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.

Cancer Res.

64

8193-8198

2004

751535

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

751536

Dgany O.,Avidan N.,Delaunay J.,Krasnov T.,Shalmon L.,Shalev H.,Eidelitz-Markus T.,Kapelushnik J.,Cattan D.,Pariente A.,Tulliez M.,Cretien A.,Schischmanoff P.-O.,Iolascon A.,Fibach E.,Koren A.,Roessler J.,Le Merrer M.,Yaniv I.,Zaizov R.,Ben-Asher E.,Olender T.,Lancet D.,Beckmann J.S.,Tamary H.

Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.

Am. J. Hum. Genet.

71

1467-1474

2002

751537

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

751538

Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.

The full-ORF clone resource of the German cDNA consortium.

BMC Genomics

8

399-399

2007

751539

Kwon Y.T.,Reiss Y.,Fried V.A.,Hershko A.,Yoon J.K.,Gonda D.K.,Sangan P.,Copeland N.G.,Jenkins N.A.,Varshavsky A.

The mouse and human genes encoding the recognition component of the N-end rule pathway.

Proc. Natl. Acad. Sci. U.S.A.

95

7898-7903

1998

751540

Yin J.,Kwon Y.T.,Varshavsky A.,Wang W.

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

Hum. Mol. Genet.

13

2421-2430

2004

751541

Matsuoka S.,Ballif B.A.,Smogorzewska A.,McDonald E.R. III,Hurov K.E.,Luo J.,Bakalarski C.E.,Zhao Z.,Solimini N.,Lerenthal Y.,Shiloh Y.,Gygi S.P.,Elledge S.J.

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Science

316

1160-1166

2007

751542

Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

Mol. Cell

31

438-448

2008

751543

Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.

Large-scale proteomics analysis of the human kinome.

Mol. Cell. Proteomics

8

1751-1764

2009

751544

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

0-0

2009

751545

Kume K.,Iizumi Y.,Shimada M.,Ito Y.,Kishi T.,Yamaguchi Y.,Handa H.

Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.

Genes Cells

15

339-349

2010

751546

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

751547

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

751548

Matta-Camacho E.,Kozlov G.,Li F.F.,Gehring K.

Structural basis of substrate recognition and specificity in the N-end rule pathway.

Nat. Struct. Mol. Biol.

17

1182-1187

2010

751549

Zenker M.,Mayerle J.,Lerch M.M.,Tagariello A.,Zerres K.,Durie P.R.,Beier M.,Hulskamp G.,Guzman C.,Rehder H.,Beemer F.A.,Hamel B.C.J.,Vanlieferinghen P.,Gershoni-Baruch R.,Vieira M.W.,Dumic M.,Auslender R.,Gil-da-Silva-Lopes V.L.,Steinlicht S.,Rauh M.,Shalev S.A.,Thiel C.,Winterpacht A.,Kwon Y.T.,Varshavsky A.,Reis A.

Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).

Nat. Genet.

37

1345-1350

2005

751550

Hwang C.S.,Sukalo M.,Batygin O.,Addor M.C.,Brunner H.,Aytes A.P.,Mayerle J.,Song H.K.,Varshavsky A.,Zenker M.

Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome.

PLoS ONE

6

0-0

2011

751551

Almashraki N.,Abdulnabee M.Z.,Sukalo M.,Alrajoudi A.,Sharafadeen I.,Zenker M.

Johanson-Blizzard syndrome.

World J. Gastroenterol.

17

4247-4250

2011

751552

Sukalo M.,Fiedler A.,Guzman C.,Spranger S.,Addor M.C.,McHeik J.N.,Oltra Benavent M.,Cobben J.M.,Gillis L.A.,Shealy A.G.,Deshpande C.,Bozorgmehr B.,Everman D.B.,Stattin E.L.,Liebelt J.,Keller K.M.,Bertola D.R.,van Karnebeek C.D.,Bergmann C.,Liu Z.,Dueker G.,Rezaei N.,Alkuraya F.S.,Ogur G.,Alrajoudi A.,Venegas-Vega C.A.,Verbeek N.E.,Richmond E.J.,Kirbiyik O.,Ranganath P.,Singh A.,Godbole K.,Ali F.A.,Alves C.,Mayerle J.,Lerch M.M.,Witt H.,Zenker M.

Mutations in the human UBR1 gene and the associated phenotypic spectrum.

Hum. Mutat.

35

521-531

2014

751553

Atik T.,Karakoyun M.,Sukalo M.,Zenker M.,Ozkinay F.,Aydogdu S.

Two novel UBR1 gene mutations in a patient with Johanson Blizzard Syndrome: A mild phenotype without mental retardation.

Gene

570

153-155

2015