Sequence of ALKB1_MOUSE
EC Number:1.14.11.51
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2
Other sequences found for EC No. 1.14.11.51
General information:
Sequence
0 MGKMAAAVAS LATLAAEPRE DAFRKLFRFY RQSRPGTADL GAVIDFSEAH LARSPKPGVP
60 QVVRFPLNVS SVTERDAERV GLEPVSKWRA YGLEGYPGFI FIPNPFLPGC QRHWVKQCLK
120 LYSQKPNVCN LDKHMTKEET QGLWEQSKEV LRSKEVTKRR PRSLLERLRW VTLGYHYNWD
180 SKKYSADHYT PFPSDLAFLS EQVATACGFQ GFQAEAGILN YYRLDSTLGI HVDRSELDHS
240 KPLLSFSFGQ SAIFLLGGLK RDEAPTAMFM HSGDIMVMSG FSRLLNHAVP RVLPHPDGEC
300 LPHCLETPLP AVLPSNSLVE PCSVEDWQVC ATYLRTARVN MTVRQVLATG QDFPLEPVEE
360 TKRDIAADGL CHLHDPNSPV KRKRLNPNS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
130697
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
130698
Pan Z.,Sikandar S.,Witherspoon M.,Dizon D.,Nguyen T.,Benirschke K.,Wiley C.,Vrana P.,Lipkin S.M.
Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.
Dev. Dyn.
237
316-327
2008
130699
Nordstrand L.M.,Svaerd J.,Larsen E.,Nilsen A.,Ougland R.,Furu K.,Lien G.F.,Rognes T.,Namekawa S.H.,Lee J.T.,Klungland A.
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.
PLoS ONE
5
0-0
2010
130700
Ougland R.,Lando D.,Jonson I.,Dahl J.A.,Moen M.N.,Nordstrand L.M.,Rognes T.,Lee J.T.,Klungland A.,Kouzarides T.,Larsen E.
ALKBH1 is a histone H2A dioxygenase involved in neural differentiation.
Stem Cells
30
2672-2682
2012
130701
Mueller T.A.,Yu K.,Hausinger R.P.,Meek K.
ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination.
PLoS ONE
8
0-0
2013
130702
Wu T.P.,Wang T.,Seetin M.G.,Lai Y.,Zhu S.,Lin K.,Liu Y.,Byrum S.D.,Mackintosh S.G.,Zhong M.,Tackett A.,Wang G.,Hon L.S.,Fang G.,Swenberg J.A.,Xiao A.Z.
DNA methylation on N(6)-adenine in mammalian embryonic stem cells.
Nature
532
329-333
2016
130703
Liu F.,Clark W.,Luo G.,Wang X.,Fu Y.,Wei J.,Wang X.,Hao Z.,Dai Q.,Zheng G.,Ma H.,Han D.,Evans M.,Klungland A.,Pan T.,He C.
ALKBH1-mediated tRNA demethylation regulates translation.
Cell
167
816-828
2016
