Sequence of SEP1_CAEEL
EC Number:3.4.22.49
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage
Other sequences found for EC No. 3.4.22.49
General information:
Sequence
0 MKITNKSVDK QHIEKLDELR KNVSCTVIGF AEQTAELQQE ISELFIAEFG VNGPIDMNSL
60 SKLARITSYY ASSEYFQGLA KYQRTACKMF ITWQTLRKEA MECRSKDREI FASIPAKLCF
120 FYFYNGELCR AVVCLLDYID LSDDTLAKEA ALRWLMFLGE TELIEKKLKT WKMDKSSKDM
180 FSATEFAMNY LKKSEYRVEM LEKLMKLRDK VKSDPTRSFS RYELASYVSW LCSTLSNVPV
240 GSALRECEFP DRVSHIQEAA LKSDSLVRNR IPGLASSQFD NSVNASIWPF LDGHQEDSNY
300 YVHIGSTIAW HFEMRRECAL VNVTTAQTRD SMSAMILNLR VALKSASFFR VLQTTNTLAY
360 YSSIIEEAGS EKNAKLMRVS CVNLLSSNPI IVRCSTPKET GATSRAHTPM AGSSVSEKQN
420 TMRPDLADLL GDLELLDEQS FHPITRSCVC NVCTIYPLHS SFAAEYMMSY AIHSDFSQLS
480 IKHFNDEFAR IRERGMSSQV LMHRDSSVRP RPNIIQNEIF GMCVIRWLTK KLDSKESADE
540 DTMEIFNNAL KIVRYLQQRT TDMILAVTQL GRQLEFPMEC NYSWMRPTIR KPRVKATIDC
600 AVDILRAVSP FGRRPKVEKL EKNLQPFDKE RFEKVRLAMR NEMNHYGHIL YREWRCRLFA
660 YVGRTSRDPW EAAYAWAEST QIGARNAVQS RLEKCKRGLV TMSGHDRFKT CVQSMPDEMT
720 LVQIAMADDK TIYLVKLHAD RDPIIMPLAH YSQAVELMDK FTFLLDEDEM IAKYPGDITP
780 EEFWKRRKIV DGRMMTFVDE VQKHFLGVAA SLLMPSGQLG PKAAELAIKI HKLSKGGLLL
840 GEAKEMVYQS KLMDAKSWEA LILRFCEMRT TDEKFKSFLP LMHRNSVEVM NQDDSIVTEK
900 KYTYLVICPH LSQFCWERLP IFDEYPYVGR QVSIHSTFSQ LEAMKSQEKQ IPLQIDVQNA
960 YYILDPDNNL GETQKRMVEY INKFNWEGTV GSAPKSNEIS AALSQRDAFF FIGHGSGSSV
1020 MPRSVLKQST CNAISLLMGC GSVRTIPQAL GFDGKTAILD YAMAKCPLIV GCLWTVTDGE
1080 IDRFLIRMID DCFEDSKSLT GIDKLRQLSE AMHEARSKAR LKYLTGAAVV MYGLPVVAKQ
1140 TTPFVEKDQR NLPQTPKTSA RTSMRMETVP KTPKQEFVTS KSVPMTPIFS NNENKSPSRA
1200 RMPSRVLKTP RQVKTFQEED DEAPKRSTTR QLKPLVAPPI PATPTTRTTR SSARTPSRSR
1260 NL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1254074
Siomos M.F.,Badrinath A.,Pasierbek P.,Livingstone D.,White J.,Glotzer M.,Nasmyth K.
Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.
Curr. Biol.
11
1825-1835
2001
1254075
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science
282
2012-2018
1998
1254076
Kitagawa R.,Law E.,Tang L.,Rose A.M.
The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans.
Curr. Biol.
12
2118-2123
2002
1254077
Rappleye C.A.,Tagawa A.,Lyczak R.,Bowerman B.,Aroian R.V.
The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation.
Dev. Cell
2
195-206
2002
1254078
Bembenek J.N.,Richie C.T.,Squirrell J.M.,Campbell J.M.,Eliceiri K.W.,Poteryaev D.,Spang A.,Golden A.,White J.G.
Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase.
Development
134
3837-3848
2007
1254079
Bembenek J.N.,White J.G.,Zheng Y.
A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody.
Curr. Biol.
20
259-264
2010
1254080
Richie C.T.,Bembenek J.N.,Chestnut B.,Furuta T.,Schumacher J.M.,Wallenfang M.,Golden A.
Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans.
J. Cell Sci.
124
2903-2913
2011
1254081
Wang R.,Kaul Z.,Ambardekar C.,Yamamoto T.G.,Kavdia K.,Kodali K.,High A.A.,Kitagawa R.
HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans.
Development
140
2149-2159
2013
1254082
Schvarzstein M.,Pattabiraman D.,Bembenek J.N.,Villeneuve A.M.
Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis.
Proc. Natl. Acad. Sci. U.S.A.
110
0-0
2013
1254083
Monen J.,Hattersley N.,Muroyama A.,Stevens D.,Oegema K.,Desai A.
Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans.
PLoS ONE
10
0-0
2015
1254084
Bachmann G.,Richards M.W.,Winter A.,Beuron F.,Morris E.,Bayliss R.
A closed conformation of the Caenorhabditis elegans separase-securin complex.
Open Biol.
6
160032-160032
2016
1254085
Boland A.,Martin T.G.,Zhang Z.,Yang J.,Bai X.C.,Chang L.,Scheres S.H.,Barford D.
Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
Nat. Struct. Mol. Biol.
24
414-418
2017
