Sequence of TOP1_ECOLI
EC Number:5.6.2.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Other sequences found for EC No. 5.6.2.1
General information:
Sequence
0 MGKALVIVES PAKAKTINKY LGSDYVVKSS VGHIRDLPTS GSAAKKSADS TSTKTAKKPK
60 KDERGALVNR MGVDPWHNWE AHYEVLPGKE KVVSELKQLA EKADHIYLAT DLDREGEAIA
120 WHLREVIGGD DARYSRVVFN EITKNAIRQA FNKPGELNID RVNAQQARRF MDRVVGYMVS
180 PLLWKKIARG LSAGRVQSVA VRLVVERERE IKAFVPEEFW EVDASTTTPS GEALALQVTH
240 QNDKPFRPVN KEQTQAAVSL LEKARYSVLE REDKPTTSKP GAPFITSTLQ QAASTRLGFG
300 VKKTMMMAQR LYEAGYITYM RTDSTNLSQD AVNMVRGYIS DNFGKKYLPE SPNQYASKEN
360 SQEAHEAIRP SDVNVMAESL KDMEADAQKL YQLIWRQFVA CQMTPAKYDS TTLTVGAGDF
420 RLKARGRILR FDGWTKVMPA LRKGDEDRIL PAVNKGDALT LVELTPAQHF TKPPARFSEA
480 SLVKELEKRG IGRPSTYASI ISTIQDRGYV RVENRRFYAE KMGEIVTDRL EENFRELMNY
540 DFTAQMENSL DQVANHEAEW KAVLDHFFSD FTQQLDKAEK DPEEGGMRPN QMVLTSIDCP
600 TCGRKMGIRT ASTGVFLGCS GYALPPKERC KTTINLVPEN EVLNVLEGED AETNALRAKR
660 RCPKCGTAMD SYLIDPKRKL HVCGNNPTCD GYEIEEGEFR IKGYDGPIVE CEKCGSEMHL
720 KMGRFGKYMA CTNEECKNTR KILRNGEVAP PKEDPVPLPE LPCEKSDAYF VLRDGAAGVF
780 LAANTFPKSR ETRAPLVEEL YRFRDRLPEK LRYLADAPQQ DPEGNKTMVR FSRKTKQQYV
840 SSEKDGKATG WSAFYVDGKW VEGKK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
110420
Tse-Dinh Y.-C.,Wang J.C.
Complete nucleotide sequence of the topA gene encoding Escherichia coli DNA topoisomerase I.
J. Mol. Biol.
191
321-331
1986
110422
Aiba H.,Baba T.,Fujita K.,Hayashi K.,Inada T.,Isono K.,Itoh T.,Kasai H.,Kashimoto K.,Kimura S.,Kitakawa M.,Kitagawa M.,Makino K.,Miki T.,Mizobuchi K.,Mori H.,Mori T.,Motomura K.,Nakade S.,Nakamura Y.,Nashimoto H.,Nishio Y.,Oshima T.,Saito N.,Sampei G.,Seki Y.,Sivasundaram S.,Tagami H.,Takeda J.,Takemoto K.,Takeuchi Y.,Wada C.,Yamamoto Y.,Horiuchi T.
A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.
DNA Res.
3
363-377
1996
110423
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
110424
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
110425
Ostrowski J.,Jagura-Burdzy G.,Kredich N.M.
DNA sequences of the cysB regions of Salmonella typhimurium and Escherichia coli.
J. Biol. Chem.
262
5999-6005
1987
110426
VanBogelen R.A.,Abshire K.Z.,Moldover B.,Olson E.R.,Neidhardt F.C.
Escherichia coli proteome analysis using the gene-protein database.
Electrophoresis
18
1243-1251
1997
110427
Chen S.J.,Wang J.C.
Identification of active site residues in Escherichia coli DNA topoisomerase I.
J. Biol. Chem.
273
6050-6056
1998
110428
Zhu C.X.,Tse-Dinh Y.C.
The acidic triad conserved in type IA DNA topoisomerases is required for binding of Mg(II) and subsequent conformational change.
J. Biol. Chem.
275
5318-5322
2000
110429
Tan J.,Kan N.,Wang W.,Ling J.,Qu G.,Jin J.,Shao Y.,Liu G.,Chen H.
Construction of 2,4,6-trinitrotoluene biosensors with novel sensing elements from Escherichia coli K-12 MG1655.
Cell Biochem. Biophys.
72
417-428
2015
110430
Lima C.D.,Wang J.C.,Mondragon A.
Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I.
Nature
367
138-146
1994
110431
Yu L.,Zhu C.-X.,Tse-Dinh Y.-C.,Fesik S.W.
Solution structure of the C-terminal single-stranded DNA-binding domain of Escherichia coli topoisomerase I.
Biochemistry
34
7622-7628
1995
110432
Feinberg H.,Lima C.D.,Mondragon A.
Conformational changes in E. coli DNA topoisomerase I.
Nat. Struct. Biol.
6
918-922
1999
110433
Feinberg H.,Changela A.,Mondragon A.
Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat. Struct. Biol.
6
961-968
1999
110434
Perry K.,Mondragon A.
Structure of a complex between E. coli DNA topoisomerase I and single-stranded DNA.
Structure
11
1349-1358
2003
110435
Zhang Z.,Cheng B.,Tse-Dinh Y.C.
Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I.
Proc. Natl. Acad. Sci. U.S.A.
108
6939-6944
2011
