Sequence of NOVP_STRNV
EC Number:2.1.1.285
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-adenosyl-L-methionine + demethyldecarbamoylnovobiocin = S-adenosyl-L-homocysteine + decarbamoylnovobiocin
Other sequences found for EC No. 2.1.1.285
General information:
Sequence
0 MAPIVETAKE TNSDSSLYLD LMIKVLAGTV YEDPAHRENF SHRDSTYREE VRNEGRDWPA
60 NAHTMIGIKR LENIRQCVED VIGNNVPGDL VETGVWRGGA CILMRGILRA HDVRDRTVWV
120 ADSFQGIPDV GEDGYAGDRK MALHRRNSVL AVSEEEVRRN FRNYDLLDEQ VRFLPGWFKD
180 TLPTAPIDTL AVLRMDGDLY ESTWDTLTNL YPKVSVGGYV IVDDYMMCPP CKDAVDEYRA
240 KFDIADELIT IDRDGVYWQR TR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
962322
Steffensky M.,Muhlenweg A.,Wang Z.X.,Li S.M.,Heide L.
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
Antimicrob. Agents Chemother.
44
1214-1222
2000
962323
Freel Meyers C.L.,Oberthur M.,Xu H.,Heide L.,Kahne D.,Walsh C.T.
Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring.
Angew. Chem. Int. Ed.
43
67-70
2004
962324
Pi N.,Meyers C.L.,Pacholec M.,Walsh C.T.,Leary J.A.
Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton.
Proc. Natl. Acad. Sci. U.S.A.
101
10036-10041
2004
962325
Gomez Garcia I.,Stevenson C.E.,Uson I.,Freel Meyers C.L.,Walsh C.T.,Lawson D.M.
The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily.
J. Mol. Biol.
395
390-407
2010
