Sequence of NOVM_STRNV
EC Number:2.4.1.302
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = dTDP + demethyldecarbamoyl novobiocin
Other sequences found for EC No. 2.4.1.302
General information:
Sequence
0 MRVLLTSLPG IGHLFPMVPL GWALQAAGHT VLVATDREFL PVVTGAGLSA TAVLDPVDPV
60 ELFKPVEPFG DPLSPAERTG HRCAEAGVRA LPAMRALVDV WHPDLVIAEP MELAGPAAAT
120 NAGVPWVRHS YGLIPPGPLL SVAAEVLDAE LAVLGLSALA KPARTIDVCP DSLRPSDGVA
180 TVPMRYVPYN GPAGVPDWLL AGPPARPRVC LTLGTSLPRR DPHVAPLWRL LLDELVALGQ
240 EVVIAIDESH RPLLGHLPDG VRAARIPLCD LLPTCTAIVH HGGSGSTMAA ASFGVPQLVV
300 PHFADHFTNA ERLTAVGAGL SLPHDTDDLA RISAACELIT GDGPHRAISR RLADENARRP
360 TPAVVAEGLA AEQRSMTPA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
962309
Steffensky M.,Muhlenweg A.,Wang Z.X.,Li S.M.,Heide L.
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
Antimicrob. Agents Chemother.
44
1214-1222
2000
962310
Freel Meyers C.L.,Oberthur M.,Anderson J.W.,Kahne D.,Walsh C.T.
Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.
Biochemistry
42
4179-4189
2003
962311
Albermann C.,Soriano A.,Jiang J.,Vollmer H.,Biggins J.B.,Barton W.A.,Lesniak J.,Nikolov D.B.,Thorson J.S.
Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization.
Org. Lett.
5
933-936
2003
962312
Pi N.,Meyers C.L.,Pacholec M.,Walsh C.T.,Leary J.A.
Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton.
Proc. Natl. Acad. Sci. U.S.A.
101
10036-10041
2004
