Sequence of HDHA_BACFN
EC Number:1.1.1.159
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
7alpha-hydroxysteroid dehydrogenase
Q5LA59
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)
259
27662
Reaction
cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate + NADH + H+
Other sequences found for EC No. 1.1.1.159
General information:
Sequence
0 MNRFENKIII ITGAAGGIGA STTRRIVSEG GKVVIADYSR EKADQFAAEL SNSGADVRPV
60 YFSATELKSC KELITFTMKE YGQIDVLVNN VGGTNPRRDT NIETLDMDYF DEAFHLNLSC
120 TMYLSQLVIP IMSTQGGGNI VNVASISGIT ADSNGTLYGA SKAGVINLTK YIATQTGKKN
180 IRCNAVAPGL ILTPAALNNL NEEVRKIFLG QCATPYLGEP QDVAATIAFL ASEDARYITG
240 QTIVVDGGLT IHNPTINLV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
936785
Bennett M.J.,McKnight S.L.,Coleman J.P.
Cloning and characterization of the NAD-dependent 7alpha-Hydroxysteroid dehydrogenase from Bacteroides fragilis.
Curr. Microbiol.
47
475-484
2003
936786
Cerdeno-Tarraga A.-M.,Patrick S.,Crossman L.C.,Blakely G.,Abratt V.,Lennard N.,Poxton I.,Duerden B.,Harris B.,Quail M.A.,Barron A.,Clark L.,Corton C.,Doggett J.,Holden M.T.G.,Larke N.,Line A.,Lord A.,Norbertczak H.,Ormond D.,Price C.,Rabbinowitsch E.,Woodward J.,Barrell B.G.,Parkhill J.
Extensive DNA inversions in the B. fragilis genome control variable gene expression.
Science
307
1463-1465
2005
936787
Liu Y.,Lv T.,Ren J.,Wang M.,Wu Q.,Zhu D.
The catalytic promiscuity of a microbial 7alpha-hydroxysteroid dehydrogenase. Reduction of non-steroidal carbonyl compounds.
Steroids
76
1136-1140
2011
