Sequence of NSUN2_HUMAN

tRNA (cytosine34-C5)-methyltransferase

Q08J23

767

86471

833628

Sakita-Suto S.,Kanda A.,Suzuki F.,Sato S.,Takata T.,Tatsuka M.

Aurora-B regulates RNA methyltransferase NSUN2.

Mol. Biol. Cell

18

1107-1117

2007

833629

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

833630

Schmutz J.,Martin J.,Terry A.,Couronne O.,Grimwood J.,Lowry S.,Gordon L.A.,Scott D.,Xie G.,Huang W.,Hellsten U.,Tran-Gyamfi M.,She X.,Prabhakar S.,Aerts A.,Altherr M.,Bajorek E.,Black S.,Branscomb E.,Caoile C.,Challacombe J.F.,Chan Y.M.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Lopez F.,Lou Y.,Martinez D.,Medina C.,Morgan J.,Nandkeshwar R.,Noonan J.P.,Pitluck S.,Pollard M.,Predki P.,Priest J.,Ramirez L.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wheeler J.,Wu K.,Yang J.,Dickson M.,Cheng J.-F.,Eichler E.E.,Olsen A.,Pennacchio L.A.,Rokhsar D.S.,Richardson P.,Lucas S.M.,Myers R.M.,Rubin E.M.

The DNA sequence and comparative analysis of human chromosome 5.

Nature

431

268-274

2004

833632

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

833633

Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

Cell

127

635-648

2006

833634

Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

Nat. Biotechnol.

24

1285-1292

2006

833635

Brzezicha B.,Schmidt M.,Makalowska I.,Jarmolowski A.,Pienkowska J.,Szweykowska-Kulinska Z.

Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA).

Nucleic Acids Res.

34

6034-6043

2006

833636

Cantin G.T.,Yi W.,Lu B.,Park S.K.,Xu T.,Lee J.-D.,Yates J.R. III

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

J. Proteome Res.

7

1346-1351

2008

833637

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

833638

Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem.

81

4493-4501

2009

833639

Hussain S.,Benavente S.B.,Nascimento E.,Dragoni I.,Kurowski A.,Gillich A.,Humphreys P.,Frye M.

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.

J. Cell Biol.

186

27-40

2009

833640

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

0-0

2009

833641

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

0-0

2010

833642

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

833643

Peng C.,Lu Z.,Xie Z.,Cheng Z.,Chen Y.,Tan M.,Luo H.,Zhang Y.,He W.,Yang K.,Zwaans B.M.,Tishkoff D.,Ho L.,Lombard D.,He T.C.,Dai J.,Verdin E.,Ye Y.,Zhao Y.

The first identification of lysine malonylation substrates and its regulatory enzyme.

Mol. Cell. Proteomics

10

0-0

2011

833644

Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

Sci. Signal.

4

0-0

2011

833645

Abbasi-Moheb L.,Mertel S.,Gonsior M.,Nouri-Vahid L.,Kahrizi K.,Cirak S.,Wieczorek D.,Motazacker M.M.,Esmaeeli-Nieh S.,Cremer K.,Weissmann R.,Tzschach A.,Garshasbi M.,Abedini S.S.,Najmabadi H.,Ropers H.H.,Sigrist S.J.,Kuss A.W.

Mutations in NSUN2 cause autosomal-recessive intellectual disability.

Am. J. Hum. Genet.

90

847-855

2012

833646

Zhang X.,Liu Z.,Yi J.,Tang H.,Xing J.,Yu M.,Tong T.,Shang Y.,Gorospe M.,Wang W.

The tRNA methyltransferase NSun2 stabilizes p16INK[4] mRNA by methylating the 3'-untranslated region of p16.

Nat. Commun.

3

712-712

2012

833647

Auxilien S.,Guerineau V.,Szweykowska-Kulinska Z.,Golinelli-Pimpaneau B.

The human tRNA m (5) C methyltransferase Misu is multisite-specific.

RNA Biol.

9

1331-1338

2012

833648

Hussain S.,Sajini A.A.,Blanco S.,Dietmann S.,Lombard P.,Sugimoto Y.,Paramor M.,Gleeson J.G.,Odom D.T.,Ule J.,Frye M.

NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs.

Cell Rep.

4

255-261

2013

833649

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

833650

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

833651

Hendriks I.A.,D'Souza R.C.,Yang B.,Verlaan-de Vries M.,Mann M.,Vertegaal A.C.

Uncovering global SUMOylation signaling networks in a site-specific manner.

Nat. Struct. Mol. Biol.

21

927-936

2014

833652

Yang X.,Yang Y.,Sun B.F.,Chen Y.S.,Xu J.W.,Lai W.Y.,Li A.,Wang X.,Bhattarai D.P.,Xiao W.,Sun H.Y.,Zhu Q.,Ma H.L.,Adhikari S.,Sun M.,Hao Y.J.,Zhang B.,Huang C.M.,Huang N.,Jiang G.B.,Zhao Y.L.,Wang H.L.,Sun Y.P.,Yang Y.G.

5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader.

Cell Res.

27

606-625

2017

833653

Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

Nat. Struct. Mol. Biol.

24

325-336

2017

833654

Chen X.,Li A.,Sun B.F.,Yang Y.,Han Y.N.,Yuan X.,Chen R.X.,Wei W.S.,Liu Y.,Gao C.C.,Chen Y.S.,Zhang M.,Ma X.D.,Liu Z.W.,Luo J.H.,Lyu C.,Wang H.L.,Ma J.,Zhao Y.L.,Zhou F.J.,Huang Y.,Xie D.,Yang Y.G.

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs.

Nat. Cell Biol.

21

978-990

2019

833655

Sajini A.A.,Choudhury N.R.,Wagner R.E.,Borneloev S.,Selmi T.,Spanos C.,Dietmann S.,Rappsilber J.,Michlewski G.,Frye M.

Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation.

Nat. Commun.

10

2550-2550

2019

833656

Van Haute L.,Lee S.Y.,McCann B.J.,Powell C.A.,Bansal D.,Vasiliauskaite L.,Garone C.,Shin S.,Kim J.S.,Frye M.,Gleeson J.G.,Miska E.A.,Rhee H.W.,Minczuk M.

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs.

Nucleic Acids Res.

47

8720-8733

2019

833657

Shinoda S.,Kitagawa S.,Nakagawa S.,Wei F.Y.,Tomizawa K.,Araki K.,Araki M.,Suzuki T.,Suzuki T.

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs.

Nucleic Acids Res.

47

8734-8745

2019

833658

Gkatza N.A.,Castro C.,Harvey R.F.,Heiss M.,Popis M.C.,Blanco S.,Borneloev S.,Sajini A.A.,Gleeson J.G.,Griffin J.L.,West J.A.,Kellner S.,Willis A.E.,Dietmann S.,Frye M.

Cytosine-5 RNA methylation links protein synthesis to cell metabolism.

PLoS Biol.

17

0-0

2019

833659

Dai W.,Li A.,Yu N.J.,Nguyen T.,Leach R.W.,Wuehr M.,Kleiner R.E.

Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation.

Nat. Chem. Biol.

17

1178-1187

2021

833660

Khan M.A.,Rafiq M.A.,Noor A.,Hussain S.,Flores J.V.,Rupp V.,Vincent A.K.,Malli R.,Ali G.,Khan F.S.,Ishak G.E.,Doherty D.,Weksberg R.,Ayub M.,Windpassinger C.,Ibrahim S.,Frye M.,Ansar M.,Vincent J.B.

Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability.

Am. J. Hum. Genet.

90

856-863

2012