Sequence of PATK_ASPCL
EC Number:2.3.1.165
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
6-methylsalicylic-acid synthase
A1CFL8
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)
1720
185005
Reaction
acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
Other sequences found for EC No. 2.3.1.165
General information:
Sequence
0 MDKQSASGEI PAMRWEPYHR RDPRNAKELS KTTSRGYFLD HLEDFDSQFF GISPKEAEQM
60 DPQQRISLEV AWEALEDAGI PAKGLSGSDT AVFWGVNSDD YSKLVLEDLP NIEAWMGIGT
120 AYCGIPNRIS YHLNLMGPST AVDAACASSL VAIHHGVQAI QLGESKIAIV GGVNALCGPG
180 LTRVLDKAGA ISSEGFCRSF DDEAKGYGRG EGAAAIILKN LSRAINDKDR ILAVIKGSAV
240 AQDGKTNGIM APNAKAQQLV AQNALAVGNI DPLTVRYVEA HATSTPLGDP TEISAIAAVY
300 GVGRDSQDPC FIGSIKPNIG HLEAGAGAMG FIKATLAIRK GILPPQANLN KLNSRIDWDK
360 AGVKVVQEAT KWPETDTIRR ASICSYGYGG TVSHAVIEQF LPLSGLESLQ TQSPDGPGVL
420 LLSGPQQKRL SVQAETLRKW IAQDGRNHDL SSVLTTLATR RDHHDYRAAM VVESHDDAET
480 ALEALAKGAD HPLVAQGRVL GTDIRKDVVW VFSGHGAQWT DMGKELLNNP VFYRAIQPLD
540 ELVQAEIGLS PIEMLLTGDF DSSDRVQILT YIMQIGISAV LKSNGVFPQA IIGHSVGEIA
600 ASVVAGALTP AEGALIVTRR AALYRRVMGQ GGMILVNLPA SQVEQELGQR EDLVVAIESS
660 PSSCVVAGDR DVVAQAAESF KERGVKTFTV KTDIAFHSPT LNGLIDPMLE ALAEDLAPST
720 PTVRLFSTSL VDPRGQDLRD IHYWTNNMVN RVRLTSAVNA AVEEGYRIFL EVSSHPVVTH
780 SINETLMDGG LEDFAVIPTL LRQKPTEKHI LYSIAQLHCR GAEVDWKAQL PGPWADGLPT
840 TTWMHKPIWR KIESAPLHTG LTHDVEKHTL LGQRIGIAGT NTTVYTTRLD NDTKPFPGSH
900 PLHGTEIVPA AGLINTFMKG TGGRRLQNVV LRVPVAINAP RSVQVVVQED QVKIMSRLLS
960 DTPQATEDDS SWATHTTAYW ARDIQEAVDP IDIAAVKKRL GTRIRDDFSI NYLDQVGVSA
1020 MGFPWAITEH YHKDKEMIAR VDVNPAVTGD APLPWDSSSW APILDAATSV GSTVFGTPAL
1080 RMPAQIDRVD IFTSQDPPKI GWLYVEDASD AAPTSHVSVL NEAGEVVAKF TAMRFSEIEG
1140 TPGVSGSMES LVHQLAWPPA TPAEEPLSID TVLLVSSDAA TMRQYANTIP RGVRSFEFSS
1200 VQDLISQDKS GLRLDKGTAV AYIPGEVQSL EEIPAASESF TWEVLELVKY IVKGGLPLKA
1260 FILTSNVGSG ETPTALAQAP LFGLARIIAS EHPDLGCLID SENPVFPLTA MRYIQGADVI
1320 RINDDVARTA RLRSLPRNKL HPASQPPRLL PRSEGTYLIT GGLGVLGLET ADFLVENGAR
1380 RLILISRRAL PPRRTWDAAP SDLQPTLAKI RNLESRGATV HILPLDISHP AAATQLSTAL
1440 DTLSLPPVLG VVHAAGVLDN QLILETTRDA FTRVLAPKIA GALALHAVFP PNTLDFFLLF
1500 SSCGNLFGFP GQASYGAGNA FLDTLATHRA RLGDAAVAVQ WTSWRGMGMG ASTEFINAEL
1560 ESKGITDVTR DEAFGAWLHL ARYDIDHGVV LRSLAFDEGE PLPVSILTDI AVRRVGVAAA
1620 GDVPGTAAAG GADAIPSSGP ELKVYLDEKI RGCVAKVLQM GAEDVDSKAA LADLGVDSVM
1680 TVSLRRQLQQ TLKVKVPSTL TWSHPTVSHL VGWFAEKVGK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
583090
Fedorova N.D.,Khaldi N.,Joardar V.S.,Maiti R.,Amedeo P.,Anderson M.J.,Crabtree J.,Silva J.C.,Badger J.H.,Albarraq A.,Angiuoli S.,Bussey H.,Bowyer P.,Cotty P.J.,Dyer P.S.,Egan A.,Galens K.,Fraser-Liggett C.M.,Haas B.J.,Inman J.M.,Kent R.,Lemieux S.,Malavazi I.,Orvis J.,Roemer T.,Ronning C.M.,Sundaram J.P.,Sutton G.,Turner G.,Venter J.C.,White O.R.,Whitty B.R.,Youngman P.,Wolfe K.H.,Goldman G.H.,Wortman J.R.,Jiang B.,Denning D.W.,Nierman W.C.
Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.
PLoS Genet.
4
0-0
2008
583092
Artigot M.P.,Loiseau N.,Laffitte J.,Mas-Reguieg L.,Tadrist S.,Oswald I.P.,Puel O.
Molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus.
Microbiology
155
1738-1747
2009
583093
de Melo F.T.,de Oliveira I.M.,Greggio S.,Dacosta J.C.,Guecheva T.N.,Saffi J.,Henriques J.A.,Rosa R.M.
DNA damage in organs of mice treated acutely with patulin, a known mycotoxin.
Food Chem. Toxicol.
50
3548-3555
2012
583094
Boussabbeh M.,Ben Salem I.,Rjiba-Touati K.,Bouyahya C.,Neffati F.,Najjar M.F.,Bacha H.,Abid-Essefi S.
The potential effect of patulin on mice bearing melanoma cells: an anti-tumour or carcinogenic effect?
Tumor Biol.
37
6285-6295
2016
