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Sequence of KEX2_YEAST

EC Number:3.4.21.61

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Kexin
P13134
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
814
90003
Reaction
Cleavage of -Lys-Arg-/- and -Arg-Arg-/- bonds to process yeast alpha-factor pheromone and killer toxin precursors
Other sequences found for EC No. 3.4.21.61

General information:

Sequence
show sequence in fasta format
  0 MKVRKYITLC FWWAFSTSAL VSSQQIPLKD HTSRQYFAVE SNETLSRLEE MHPNWKYEHD
 60 VRGLPNHYVF SKELLKLGKR SSLEELQGDN NDHILSVHDL FPRNDLFKRL PVPAPPMDSS
120 LLPVKEAEDK LSINDPLFER QWHLVNPSFP GSDINVLDLW YNNITGAGVV AAIVDDGLDY
180 ENEDLKDNFC AEGSWDFNDN TNLPKPRLSD DYHGTRCAGE IAAKKGNNFC GVGVGYNAKI
240 SGIRILSGDI TTEDEAASLI YGLDVNDIYS CSWGPADDGR HLQGPSDLVK KALVKGVTEG
300 RDSKGAIYVF ASGNGGTRGD NCNYDGYTNS IYSITIGAID HKDLHPPYSE GCSAVMAVTY
360 SSGSGEYIHS SDINGRCSNS HGGTSAAAPL AAGVYTLLLE ANPNLTWRDV QYLSILSAVG
420 LEKNADGDWR DSAMGKKYSH RYGFGKIDAH KLIEMSKTWE NVNAQTWFYL PTLYVSQSTN
480 STEETLESVI TISEKSLQDA NFKRIEHVTV TVDIDTEIRG TTTVDLISPA GIISNLGVVR
540 PRDVSSEGFK DWTFMSVAHW GENGVGDWKI KVKTTENGHR IDFHSWRLKL FGESIDSSKT
600 ETFVFGNDKE EVEPAATEST VSQYSASSTS ISISATSTSS ISIGVETSAI PQTTTASTDP
660 DSDPNTPKKL SSPRQAMHYF LTIFLIGATF LVLYFMFFMK SRRRIRRSRA ETYEFDIIDT
720 DSEYDSTLDN GTSGITEPEE VEDFDFDLSD EDHLASLSSS ENGDAEHTID SVLTNENPFS
780 DPIKQKFPND ANAESASNKL QELQPDVPPS SGRS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
561697
Mizuno K.,Nakamura T.,Ohshima T.,Tanaka S.,Matsuo H.
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases.
Biochem. Biophys. Res. Commun.
156
246-254
1988
561698
Fuller R.S.,Brake A.,Thorner J.
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
Proc. Natl. Acad. Sci. U.S.A.
86
1434-1438
1989
561699
Pandolfo D.,de Antoni A.,Lanfranchi G.,Valle G.
The DNA sequence of cosmid 14-5 from chromosome XIV reveals 21 open reading frames including a novel gene encoding a globin-like domain.
Yeast
12
1071-1076
1996
561700
Philippsen P.,Kleine K.,Poehlmann R.,Duesterhoeft A.,Hamberg K.,Hegemann J.H.,Obermaier B.,Urrestarazu L.A.,Aert R.,Albermann K.,Altmann R.,Andre B.,Baladron V.,Ballesta J.P.G.,Becam A.-M.,Beinhauer J.D.,Boskovic J.,Buitrago M.J.,Bussereau F.,Coster F.,Crouzet M.,D'Angelo M.,Dal Pero F.,De Antoni A.,del Rey F.,Doignon F.,Domdey H.,Dubois E.,Fiedler T.A.,Fleig U.,Floeth M.,Fritz C.,Gaillardin C.,Garcia-Cantalejo J.M.,Glansdorff N.,Goffeau A.,Gueldener U.,Herbert C.J.,Heumann K.,Heuss-Neitzel D.,Hilbert H.,Hinni K.,Iraqui Houssaini I.,Jacquet M.,Jimenez A.,Jonniaux J.-L.,Karpfinger-Hartl L.,Lanfranchi G.,Lepingle A.,Levesque H.,Lyck R.,Maftahi M.,Mallet L.,Maurer C.T.C.,Messenguy F.,Mewes H.-W.,Moestl D.,Nasr F.,Nicaud J.-M.,Niedenthal R.K.,Pandolfo D.,Pierard A.,Piravandi E.,Planta R.J.,Pohl T.M.,Purnelle B.,Rebischung C.,Remacha M.A.,Revuelta J.L.,Rinke M.,Saiz J.E.,Sartorello F.,Scherens B.,Sen-Gupta M.,Soler-Mira A.,Urbanus J.H.M.,Valle G.,Van Dyck L.,Verhasselt P.,Vierendeels F.,Vissers S.,Voet M.,Volckaert G.,Wach A.,Wambutt R.,Wedler H.,Zollner A.,Hani J.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.
Nature
387
93-98
1997
561701
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
561702
Brenner C.,Fuller R.S.
Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease.
Proc. Natl. Acad. Sci. U.S.A.
89
922-926
1992
561703
Germain D.,Dumas F.,Vernet T.,Bourbonnais Y.,Thomas D.Y.,Boileau G.
The pro-region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self-processing.
FEBS Lett.
299
283-286
1992
561704
Wilcox C.A.,Fuller R.S.
Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway.
J. Cell Biol.
115
297-307
1991
561705
Holyoak T.,Wilson M.A.,Fenn T.D.,Kettner C.A.,Petsko G.A.,Fuller R.S.,Ringe D.
2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor.
Biochemistry
42
6709-6718
2003