Sequence of GRK5_MOUSE
EC Number:2.7.11.16
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + [G protein-coupled receptor] = ADP + [G protein-coupled receptor]phosphate
Other sequences found for EC No. 2.7.11.16
General information:
Sequence
0 MELENIVANT VLLKAREGGG GKRKGKSKKW KEILKFPHIS QCEDLRRTID RDYYSLCDKQ
60 PIGRLLFRQF CETRPGLECY IQFLDLVAEY EITPDENLGA KGKEIMTKYL TPKSPVFIAQ
120 VGQDLVSQTE KKLLQSPCKE LFSACAQSVH DYLKGDPFHE YLDSMYFDRF LQWKWLERQP
180 VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKRLEKK RIKKRKGESM ALNEKQILEK
240 VNSQFVVNLA YAYETKDALC LVLTIMNGGD LKFHIYNMGN PGFEEERALF YAAEILCGLE
300 DLHRENTVYR DLKPENILLD DYGHIRISDL GLAVKIPEGD LIRGRVGTVG YMAPEVLNNQ
360 RYGLSPDYWG LGCLIYEMIE GQSPFRGRKE KVKREEVDRR VLETEEVYSS KFSEEAKSIC
420 NMLLTKDSKQ RLGCQEEGAA EVKRHPFFRN MNFKRLEAGM LDPPFVPDPR AVYCKDVLDI
480 EQFSTVKGVN LDHTDDDFYS KFSTGSVPIP WQNEMIETEC FKELNVFGPN GTLSPDLNRS
540 QPPEPPKKGL FHRLFRRQHQ SNSKSSPTPK TSCNHRINSN HINSNSTGSS
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in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
550872
Premont R.T.,Macrae A.D.,Aparicio S.A.,Kendall H.E.,Welch J.E.,Lefkowitz R.J.
The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.
J. Biol. Chem.
274
29381-29389
1999
550873
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
550874
Gainetdinov R.R.,Bohn L.M.,Walker J.K.,Laporte S.A.,Macrae A.D.,Caron M.G.,Lefkowitz R.J.,Premont R.T.
Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.
Neuron
24
1029-1036
1999
550875
Walker J.K.,Gainetdinov R.R.,Feldman D.S.,McFawn P.K.,Caron M.G.,Lefkowitz R.J.,Premont R.T.,Fisher J.T.
G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.
Am. J. Physiol.
286
0-0
2004
550876
Villen J.,Beausoleil S.A.,Gerber S.A.,Gygi S.P.
Large-scale phosphorylation analysis of mouse liver.
Proc. Natl. Acad. Sci. U.S.A.
104
1488-1493
2007
550877
Martini J.S.,Raake P.,Vinge L.E.,DeGeorge B.R. Jr.,Chuprun J.K.,Harris D.M.,Gao E.,Eckhart A.D.,Pitcher J.A.,Koch W.J.
Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.
Proc. Natl. Acad. Sci. U.S.A.
105
12457-12462
2008
550878
Liu J.,Rasul I.,Sun Y.,Wu G.,Li L.,Premont R.T.,Suo W.Z.
GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.
J. Biol. Chem.
284
19564-19571
2009
550879
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
550880
Cheng S.,Li L.,He S.,Liu J.,Sun Y.,He M.,Grasing K.,Premont R.T.,Suo W.Z.
GRK5 deficiency accelerates beta-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.
J. Biol. Chem.
285
41541-41548
2010
