Sequence of GRK5_HUMAN

G-protein-coupled receptor kinase

P34947

590

67787

550855

Kunapuli P.,Benovic J.L.

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

Proc. Natl. Acad. Sci. U.S.A.

90

5588-5592

1993

550856

Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.

The DNA sequence and comparative analysis of human chromosome 10.

Nature

429

375-381

2004

550858

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

550859

Ungerer M.,Bohm M.,Elce J.S.,Erdmann E.,Lohse M.J.

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

Circulation

87

454-463

1993

550860

Kunapuli P.,Gurevich V.V.,Benovic J.L.

Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.

J. Biol. Chem.

269

10209-10212

1994

550861

Pronin A.N.,Satpaev D.K.,Slepak V.Z.,Benovic J.L.

Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain.

J. Biol. Chem.

272

18273-18280

1997

550862

Thiyagarajan M.M.,Stracquatanio R.P.,Pronin A.N.,Evanko D.S.,Benovic J.L.,Wedegaertner P.B.

A predicted amphipathic helix mediates plasma membrane localization of GRK5.

J. Biol. Chem.

279

17989-17995

2004

550863

Johnson L.R.,Scott M.G.,Pitcher J.A.

G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence.

Mol. Cell. Biol.

24

10169-10179

2004

550864

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

550865

Barthet G.,Carrat G.,Cassier E.,Barker B.,Gaven F.,Pillot M.,Framery B.,Pellissier L.P.,Augier J.,Kang D.S.,Claeysen S.,Reiter E.,Baneres J.L.,Benovic J.L.,Marin P.,Bockaert J.,Dumuis A.

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

EMBO J.

28

2706-2718

2009

550866

Chen M.,Philipp M.,Wang J.,Premont R.T.,Garrison T.R.,Caron M.G.,Lefkowitz R.J.,Chen W.

G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

J. Biol. Chem.

284

35040-35048

2009

550867

Chen X.,Zhu H.,Yuan M.,Fu J.,Zhou Y.,Ma L.

G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.

J. Biol. Chem.

285

12823-12830

2010

550868

Baameur F.,Morgan D.H.,Yao H.,Tran T.M.,Hammitt R.A.,Sabui S.,McMurray J.S.,Lichtarge O.,Clark R.B.

Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.

Mol. Pharmacol.

77

405-415

2010

550869

Barker B.L.,Benovic J.L.

G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4.

Biochemistry

50

6933-6941

2011

550870

Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.

Patterns of somatic mutation in human cancer genomes.

Nature

446

153-158

2007

550871

Liggett S.B.,Cresci S.,Kelly R.J.,Syed F.M.,Matkovich S.J.,Hahn H.S.,Diwan A.,Martini J.S.,Sparks L.,Parekh R.R.,Spertus J.A.,Koch W.J.,Kardia S.L.,Dorn G.W. II

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.

Nat. Med.

14

510-517

2008