Any feedback?
Please rate this page
(sequences.php)
(0/150)

BRENDA support

Sequence of KAPCA_MOUSE

EC Number:2.7.11.11

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cAMP-dependent protein kinase
P05132
Mus musculus
351
40571
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.11

General information:

Sequence
show sequence in fasta format
  0 MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WETPSQNTAQ LDQFDRIKTL GTGSFGRVML
 60 VKHKESGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV
120 MEYVAGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY
180 IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF
240 ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT
300 TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFTE F
Download this sequence
in fasta format
Download all sequences for 2.7.11.11
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
50159
Chrivia J.C.,Uhler M.D.,McKnight G.S.
Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase.
J. Biol. Chem.
263
5739-5744
1988
50160
Uhler M.D.,Carmichael D.F.,Lee D.C.,Chrivia J.C.,Krebs E.G.,McKnight G.S.
Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase.
Proc. Natl. Acad. Sci. U.S.A.
83
1300-1304
1986
50161
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
50162
San Agustin J.T.,Wilkerson C.G.,Witman G.B.
The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative C-alpha mRNA expressed specifically in spermatogenic cells.
Mol. Biol. Cell
11
3031-3044
2000
50163
Yonemoto W.,Garrod S.M.,Bell S.M.,Taylor S.S.
Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase.
J. Biol. Chem.
268
18626-18632
1993
50164
Cheng X.,Ma Y.,Moore M.,Hemmings B.A.,Taylor S.S.
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.
Proc. Natl. Acad. Sci. U.S.A.
95
9849-9854
1998
50165
Huang W.,Zhou X.,Lefebvre V.,de Crombrugghe B.
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.
Mol. Cell. Biol.
20
4149-4158
2000
50166
Tholey A.,Pipkorn R.,Bossemeyer D.,Kinzel V.,Reed J.
Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry
40
225-231
2001
50167
Skaalhegg B.S.,Huang Y.,Su T.,Idzerda R.L.,McKnight G.S.,Burton K.A.
Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction.
Mol. Endocrinol.
16
630-639
2002
50168
Nolan M.A.,Babcock D.F.,Wennemuth G.,Brown W.,Burton K.A.,McKnight G.S.
Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility.
Proc. Natl. Acad. Sci. U.S.A.
101
13483-13488
2004
50169
Webb R.J.,Tinworth L.,Thomas G.M.,Zaccolo M.,Carroll J.
Developmentally acquired PKA localisation in mouse oocytes and embryos.
Dev. Biol.
317
36-45
2008
50170
Pirino G.,Wescott M.P.,Donovan P.J.
Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes.
Cell Cycle
8
665-670
2009
50171
Baker M.A.,Hetherington L.,Curry B.,Aitken R.J.
Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation.
Dev. Biol.
333
57-66
2009
50172
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
50173
Caldwell G.B.,Howe A.K.,Nickl C.K.,Dostmann W.R.,Ballif B.A.,Deming P.B.
Direct modulation of the protein kinase A catalytic subunit alpha by growth factor receptor tyrosine kinases.
J. Cell. Biochem.
113
39-48
2012
50174
Stanger S.J.,Law E.A.,Jamsai D.,O'Bryan M.K.,Nixon B.,McLaughlin E.A.,Aitken R.J.,Roman S.D.
A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation.
FASEB J.
30
2777-2791
2016
50175
Knighton D.R.,Zheng J.,ten Eyck L.F.,Ashford V.A.,Xuong N.-H.,Taylor S.S.,Sowadski J.M.
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.
Science
253
407-414
1991
50176
Zheng J.,Knighton D.R.,ten Eyck L.F.,Karlsson R.,Xuong N.-H.,Taylor S.S.,Sowadski J.M.
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor.
Biochemistry
32
2154-2161
1993
50177
Narayana N.,Cox S.,Shaltiel S.,Taylor S.S.,Xuong N.
Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.
Biochemistry
36
4438-4448
1997
50178
Narayana N.,Cox S.,Nguyen-Huu X.,ten Eyck L.F.,Taylor S.S.
A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility.
Structure
5
921-935
1997
50179
Kim C.,Cheng C.Y.,Saldanha S.A.,Taylor S.S.
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.
Cell
130
1032-1043
2007
50180
Wu J.,Brown S.H.,von Daake S.,Taylor S.S.
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.
Science
318
274-279
2007
50181
Yang J.,Kennedy E.J.,Wu J.,Deal M.S.,Pennypacker J.,Ghosh G.,Taylor S.S.
Contribution of non-catalytic core residues to activity and regulation in protein kinase A.
J. Biol. Chem.
284
6241-6248
2009
50182
Brown S.H.J.,Wu J.,Kim C.,Alberto K.,Taylor S.S.
Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.
J. Mol. Biol.
393
1070-1082
2009
50183
Masterson L.R.,Cheng C.,Yu T.,Tonelli M.,Kornev A.,Taylor S.S.,Veglia G.
Dynamics connect substrate recognition to catalysis in protein kinase A.
Nat. Chem. Biol.
6
821-828
2010
50184
Zhang P.,Smith-Nguyen E.V.,Keshwani M.M.,Deal M.S.,Kornev A.P.,Taylor S.S.
Structure and allostery of the PKA RIIbeta tetrameric holoenzyme.
Science
335
712-716
2012