Sequence of DES7_STRVZ
EC Number:2.4.1.277
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin
Other sequences found for EC No. 2.4.1.277
EC Number:2.4.1.278
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
3-alpha-mycarosylerythronolide B desosaminyl transferase
Q9ZGH7
Streptomyces venezuelae
426
46423
Reaction
dTDP-D-desosamine + 3-alpha-L-mycarosylerythronolide B = dTDP + erythromycin D
Other sequences found for EC No. 2.4.1.278
EC Number:2.4.1.328
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
dTDP-beta-L-mycarose + erythronolide B = dTDP + 3-alpha-L-mycarosylerythronolide B
Other sequences found for EC No. 2.4.1.328
General information:
Sequence
0 MRVLLTSFAH HTHYYGLVPL AWALLAAGHE VRVASQPALT DTITGSGLAA VPVGTDHLIH
60 EYRVRMAGEP RPNHPAIAFD EARPEPLDWD HALGIEAILA PYFHLLANND SMVDDLVDFA
120 RSWQPDLVLW EPTTYAGAVA AQVTGAAHAR VLWGPDVMGS ARRKFVALRD RQPPEHREDP
180 TAEWLTWTLD RYGASFEEEL LTGQFTIDPT PPSLRLDTGL PTVGMRYVPY NGTSVVPDWL
240 SEPPARPRVC LTLGVSAREV LGGDGVSQGD ILEALADLDI ELVATLDASQ RAEIRNYPKH
300 TRFTDFVPMH ALLPSCSAII HHGGAGTYAT AVINAVPQVM LAELWDAPVK ARAVAEQGAG
360 FFLPPAELTP QAVRDAVVRI LDDPSVATAA HRLREETFGD PTPAGIVPEL ERLAAQHRRP
420 PADARH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
789338
Xue Y.,Zhao L.,Liu H.W.,Sherman D.H.
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
Proc. Natl. Acad. Sci. U.S.A.
95
12111-12116
1998
789339
Borisova S.A.,Zhao L.,Melancon C.E. III,Kao C.L.,Liu H.W.
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.
J. Am. Chem. Soc.
126
6534-6535
2004
789340
Borisova S.A.,Zhang C.,Takahashi H.,Zhang H.,Wong A.W.,Thorson J.S.,Liu H.W.
Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses.
Angew. Chem. Int. Ed.
45
2748-2753
2006
789341
Hong J.S.,Park S.J.,Parajuli N.,Park S.R.,Koh H.S.,Jung W.S.,Choi C.Y.,Yoon Y.J.
Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation.
Gene
386
123-130
2007
789342
Borisova S.A.,Kim H.J.,Pu X.,Liu H.W.
Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications.
ChemBioChem
9
1554-1558
2008
789343
Borisova S.A.,Liu H.W.
Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.
Biochemistry
49
8071-8084
2010
