Sequence of HDAC9_HUMAN
EC Number:3.5.1.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Other sequences found for EC No. 3.5.1.98
General information:
Sequence
0 MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMMPVVDPV VREKQLQQEL LLIQQQQQIQ
60 KQLLIAEFQK QHENLTRQHQ AQLQEHIKEL LAIKQQQELL EKEQKLEQQR QEQEVERHRR
120 EQQLPPLRGK DRGRERAVAS TEVKQKLQEF LLSKSATKDT PTNGKNHSVS RHPKLWYTAA
180 HHTSLDQSSP PLSGTSPSYK YTLPGAQDAK DDFPLRKTAS EPNLKVRSRL KQKVAERRSS
240 PLLRRKDGNV VTSFKKRMFE VTESSVSSSS PGSGPSSPNN GPTGSVTENE TSVLPPTPHA
300 EQMVSQQRIL IHEDSMNLLS LYTSPSLPNI TLGLPAVPSQ LNASNSLKEK QKCETQTLRQ
360 GVPLPGQYGG SIPASSSHPH VTLEGKPPNS SHQALLQHLL LKEQMRQQKL LVAGGVPLHP
420 QSPLATKERI SPGIRGTHKL PRHRPLNRTQ SAPLPQSTLA QLVIQQQHQQ FLEKQKQYQQ
480 QIHMNKLLSK SIEQLKQPGS HLEEAEEELQ GDQAMQEDRA PSSGNSTRSD SSACVDDTLG
540 QVGAVKVKEE PVDSDEDAQI QEMESGEQAA FMQQPFLEPT HTRALSVRQA PLAAVGMDGL
600 EKHRLVSRTH SSPAASVLPH PAMDRPLQPG SATGIAYDPL MLKHQCVCGN STTHPEHAGR
660 IQSIWSRLQE TGLLNKCERI QGRKASLEEI QLVHSEHHSL LYGTNPLDGQ KLDPRILLGD
720 DSQKFFSSLP CGGLGVDSDT IWNELHSSGA ARMAVGCVIE LASKVASGEL KNGFAVVRPP
780 GHHAEESTAM GFCFFNSVAI TAKYLRDQLN ISKILIVDLD VHHGNGTQQA FYADPSILYI
840 SLHRYDEGNF FPGSGAPNEV GTGLGEGYNI NIAWTGGLDP PMGDVEYLEA FRTIVKPVAK
900 EFDPDMVLVS AGFDALEGHT PPLGGYKVTA KCFGHLTKQL MTLADGRVVL ALEGGHDLTA
960 ICDASEACVN ALLGNELEPL AEDILHQSPN MNAVISLQKI IEIQSMSLKF S
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
680497
Zhou X.,Marks P.A.,Rifkind R.A.,Richon V.M.
Cloning and characterization of a histone deacetylase, HDAC9.
Proc. Natl. Acad. Sci. U.S.A.
98
10572-10577
2001
680498
David D.,Cardoso J.,Marques B.,Marques R.,Silva E.D.,Santos H.,Boavida M.G.
Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible position effect on TGFbeta2 in the pathogenesis of Peters' anomaly.
Genomics
81
489-503
2003
680499
Petrie K.,Guidez F.,Howell L.,Healy L.,Waxman S.,Greaves M.,Zelent A.
The histone deacetylase 9 gene encodes multiple protein isoforms.
J. Biol. Chem.
278
16059-16072
2003
680500
Nagase T.,Ishikawa K.,Suyama M.,Kikuno R.,Miyajima N.,Tanaka A.,Kotani H.,Nomura N.,Ohara O.
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
DNA Res.
5
277-286
1998
680501
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
680502
Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.
The DNA sequence of human chromosome 7.
Nature
424
157-164
2003
680504
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
680505
Wang A.H.,Bertos N.R.,Vezmar M.,Pelletier N.,Crosato M.,Heng H.H.,Th'ng J.,Han J.,Yang X.-J.
HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.
Mol. Cell. Biol.
19
7816-7827
1999
680506
Sparrow D.B.,Miska E.A.,Langley E.,Reynaud-Deonauth S.,Kotecha S.,Towers N.,Spohr G.,Kouzarides T.,Mohun T.J.
MEF-2 function is modified by a novel co-repressor, MITR.
EMBO J.
18
5085-5098
1999
680507
Zhou X.,Richon V.M.,Rifkind R.A.,Marks P.A.
Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5.
Proc. Natl. Acad. Sci. U.S.A.
97
1056-1061
2000
680508
Miska E.A.,Karlsson C.,Langley E.,Nielsen S.J.,Pines J.,Kouzarides T.
HDAC4 deacetylase associates with and represses the MEF2 transcription factor.
EMBO J.
18
5099-5107
1999
680509
Kirsh O.,Seeler J.-S.,Pichler A.,Gast A.,Mueller S.,Miska E.,Mathieu M.,Harel-Bellan A.,Kouzarides T.,Melchior F.,Dejean A.
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
EMBO J.
21
2682-2691
2002
680510
Morrison B.E.,Majdzadeh N.,Zhang X.,Lyles A.,Bassel-Duby R.,Olson E.N.,D'Mello S.R.
Neuroprotection by histone deacetylase-related protein.
Mol. Cell. Biol.
26
3550-3564
2006
680511
Li B.,Samanta A.,Song X.,Iacono K.T.,Bembas K.,Tao R.,Basu S.,Riley J.L.,Hancock W.W.,Shen Y.,Saouaf S.J.,Greene M.I.
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.
Proc. Natl. Acad. Sci. U.S.A.
104
4571-4576
2007
680512
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
680513
Harrison B.C.,Huynh K.,Lundgaard G.L.,Helmke S.M.,Perryman M.B.,McKinsey T.A.
Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.
FEBS Lett.
584
1103-1110
2010
680514
Varela I.,Tarpey P.,Raine K.,Huang D.,Ong C.K.,Stephens P.,Davies H.,Jones D.,Lin M.L.,Teague J.,Bignell G.,Butler A.,Cho J.,Dalgliesh G.L.,Galappaththige D.,Greenman C.,Hardy C.,Jia M.,Latimer C.,Lau K.W.,Marshall J.,McLaren S.,Menzies A.,Mudie L.,Stebbings L.,Largaespada D.A.,Wessels L.F.A.,Richard S.,Kahnoski R.J.,Anema J.,Tuveson D.A.,Perez-Mancera P.A.,Mustonen V.,Fischer A.,Adams D.J.,Rust A.,Chan-On W.,Subimerb C.,Dykema K.,Furge K.,Campbell P.J.,Teh B.T.,Stratton M.R.,Futreal P.A.
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
Nature
469
539-542
2011
