Sequence of NAT8_HUMAN
EC Number:2.3.1.80
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
acetyl-CoA + an L-cysteine-S-conjugate = CoA + an N-acetyl-L-cysteine-S-conjugate
Other sequences found for EC No. 2.3.1.80
General information:
Sequence
0 MAPCHIRKYQ ESDRQWVVGL LSRGMAEHAP ATFRQLLKLP RTLILLLGGP LALLLVSGSW
60 LLALVFSISL FPALWFLAKK PWTEYVDMTL CTDMSDITKS YLSERGSCFW VAESEEKVVG
120 MVGALPVDDP TLREKRLQLF HLFVDSEHRR QGIAKALVRT VLQFARDQGY SEVILDTGTI
180 QLSAMALYQS MGFKKTGQSF FCVWARLVAL HTVHFIYHLP SSKVGSL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
960040
Ozaki K.,Fujiwara T.,Nakamura Y.,Takahashi E.
Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases.
J. Hum. Genet.
43
255-258
1998
960041
Popsueva A.E.,Luchinskaya N.N.,Ludwig A.V.,Zinovjeva O.Y.,Poteryaev D.A.,Feigelman M.M.,Ponomarev M.B.,Berekelya L.,Belyavsky A.V.
Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis.
Dev. Biol.
234
483-496
2001
960044
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
960045
Ko M.H.,Puglielli L.
Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels.
J. Biol. Chem.
284
2482-2492
2009
960046
Veiga-da-Cunha M.,Tyteca D.,Stroobant V.,Courtoy P.J.,Opperdoes F.R.,Van Schaftingen E.
Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids.
J. Biol. Chem.
285
18888-18898
2010
960047
Ding Y.,Ko M.H.,Pehar M.,Kotch F.,Peters N.R.,Luo Y.,Salamat S.M.,Puglielli L.
Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation.
J. Biol. Chem.
287
8424-8433
2012
960048
Mak A.B.,Pehar M.,Nixon A.M.,Williams R.A.,Uetrecht A.C.,Puglielli L.,Moffat J.
Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation.
J. Mol. Biol.
426
2175-2182
2014
