Sequence of HYPDH_HUMAN
EC Number:1.5.5.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol
Other sequences found for EC No. 1.5.5.2
EC Number:1.5.5.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
trans-4-hydroxy-L-proline + a quinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol
Other sequences found for EC No. 1.5.5.3
General information:
Sequence
0 MSPRVVSNSS VLASQSVGIT NVRTVFSNVF NNTTAFPILR GSNCHKITAP GLGKGQLVNL
60 LPPENLPWCG GSQGPRMLRT CYVLCSQAGP PSRGWQSLSF DGGAFHLKGT GELTRALLVL
120 RLCAWPPLVT HGLLLQAWSR RLLGSRLSGA FLRASVYGQF VAGETAEEVK GCVQQLRTLS
180 LRPLLAVPTE EEPDSAAKSG EAWYEGNLGA MLRCVDLSRG LLEPPSLAEA SLMQLKVTAL
240 TSTRLCKELA SWVRRPGASL ELSPERLAEA MDSGQNLQVS CLNAEQNQHL RASLSRLHRV
300 AQYARAQHVR LLVDAEYTSL NPALSLLVAA LAVRWNSPGE GGPWVWNTYQ ACLKDTFERL
360 GRDAEAAHRA GLAFGVKLVR GAYLDKERAV AQLHGMEDPT QPDYEATSQS YSRCLELMLT
420 HVARHGPMCH LMVASHNEES VRQATKRMWE LGIPLDGTVC FGQLLGMCDH VSLALGQAGY
480 VVYKSIPYGS LEEVIPYLIR RAQENRSVLQ GARREQELLS QELWRRLLPG CRRIPH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
305038
Summitt C.B.,Johnson L.C.,Joensson T.J.,Parsonage D.,Holmes R.P.,Lowther W.T.
Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.
Biochem. J.
466
273-281
2015
