Sequence of UVRAG_HUMAN

phosphatidylinositol 3-kinase

Q9P2Y5

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1012781

Perelman B.,Dafni N.,Naiman T.,Eli D.,Yaakov M.,Feng T.L.Y.,Sinha S.,Weber G.,Khodaei S.,Sancar A.,Dotan I.,Canaani D.

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Genomics

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Iida A.,Emi M.,Matsuoka R.,Hiratsuka E.,Okui K.,Ohashi H.,Inazawa J.,Fukushima Y.,Imai T.,Nakamura Y.

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Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

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1012784

Taylor T.D.,Noguchi H.,Totoki Y.,Toyoda A.,Kuroki Y.,Dewar K.,Lloyd C.,Itoh T.,Takeda T.,Kim D.-W.,She X.,Barlow K.F.,Bloom T.,Bruford E.,Chang J.L.,Cuomo C.A.,Eichler E.,FitzGerald M.G.,Jaffe D.B.,LaButti K.,Nicol R.,Park H.-S.,Seaman C.,Sougnez C.,Yang X.,Zimmer A.R.,Zody M.C.,Birren B.W.,Nusbaum C.,Fujiyama A.,Hattori M.,Rogers J.,Lander E.S.,Sakaki Y.

Human chromosome 11 DNA sequence and analysis including novel gene identification.

Nature

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2006

1012785

Liang C.,Feng P.,Ku B.,Dotan I.,Canaani D.,Oh B.H.,Jung J.U.

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.

Nat. Cell Biol.

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2006

1012786

Takahashi Y.,Coppola D.,Matsushita N.,Cualing H.D.,Sun M.,Sato Y.,Liang C.,Jung J.U.,Cheng J.Q.,Mule J.J.,Pledger W.J.,Wang H.G.

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.

Nat. Cell Biol.

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2007

1012787

Itakura E.,Kishi C.,Inoue K.,Mizushima N.

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

Mol. Biol. Cell

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2008

1012788

Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

Mol. Cell

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2008

1012789

Liang C.,Lee J.S.,Inn K.S.,Gack M.U.,Li Q.,Roberts E.A.,Vergne I.,Deretic V.,Feng P.,Akazawa C.,Jung J.U.

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

Nat. Cell Biol.

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2008

1012790

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

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2008

1012791

Sun Q.,Fan W.,Chen K.,Ding X.,Chen S.,Zhong Q.

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

Proc. Natl. Acad. Sci. U.S.A.

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2008

1012792

Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.

Large-scale proteomics analysis of the human kinome.

Mol. Cell. Proteomics

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2009

1012793

Matsunaga K.,Saitoh T.,Tabata K.,Omori H.,Satoh T.,Kurotori N.,Maejima I.,Shirahama-Noda K.,Ichimura T.,Isobe T.,Akira S.,Noda T.,Yoshimori T.

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

Nat. Cell Biol.

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385-396

2009

1012794

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

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2009

1012795

Thoresen S.B.,Pedersen N.M.,Liestol K.,Stenmark H.

A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

Exp. Cell Res.

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1012796

Sun Q.,Westphal W.,Wong K.N.,Tan I.,Zhong Q.

Rubicon controls endosome maturation as a Rab7 effector.

Proc. Natl. Acad. Sci. U.S.A.

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2010

1012797

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

0-0

2010

1012798

Zhao Z.,Oh S.,Li D.,Ni D.,Pirooz S.D.,Lee J.H.,Yang S.,Lee J.Y.,Ghozalli I.,Costanzo V.,Stark J.M.,Liang C.

A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.

Dev. Cell

22

1001-1016

2012

1012799

McKnight N.C.,Jefferies H.B.,Alemu E.A.,Saunders R.E.,Howell M.,Johansen T.,Tooze S.A.

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

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1012800

Ma C.,Wang N.,Detre C.,Wang G.,O'Keeffe M.,Terhorst C.

Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.

J. Biol. Chem.

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2012

1012801

He C.,Wei Y.,Sun K.,Li B.,Dong X.,Zou Z.,Liu Y.,Kinch L.N.,Khan S.,Sinha S.,Xavier R.J.,Grishin N.V.,Xiao G.,Eskelinen E.L.,Scherer P.E.,Whistler J.L.,Levine B.

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

Cell

154

1085-1099

2013

1012802

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

1012803

Fogel A.I.,Dlouhy B.J.,Wang C.,Ryu S.W.,Neutzner A.,Hasson S.A.,Sideris D.P.,Abeliovich H.,Youle R.J.

Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.

Mol. Cell. Biol.

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3675-3688

2013

1012804

He S.,Ni D.,Ma B.,Lee J.H.,Zhang T.,Ghozalli I.,Pirooz S.D.,Zhao Z.,Bharatham N.,Li B.,Oh S.,Lee W.H.,Takahashi Y.,Wang H.G.,Minassian A.,Feng P.,Deretic V.,Pepperkok R.,Tagaya M.,Yoon H.S.,Liang C.

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.

Nat. Cell Biol.

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1206-1219

2013

1012805

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

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253-262

2014

1012806

Pirooz S.D.,He S.,Zhang T.,Zhang X.,Zhao Z.,Oh S.,O'Connell D.,Khalilzadeh P.,Amini-Bavil-Olyaee S.,Farzan M.,Liang C.

UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.

Proc. Natl. Acad. Sci. U.S.A.

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2716-2721

2014

1012807

Kim Y.M.,Jung C.H.,Seo M.,Kim E.K.,Park J.M.,Bae S.S.,Kim D.H.

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

Mol. Cell

57

207-218

2015

1012808

Cheng X.,Ma X.,Ding X.,Li L.,Jiang X.,Shen Z.,Chen S.,Liu W.,Gong W.,Sun Q.

Pacer mediates the function of class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17.

Mol. Cell

65

1029-1043

2017