Sequence of THIC_SALTY
EC Number:4.1.99.17
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phosphomethylpyrimidine synthase
Q9L9I7
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
631
70845
Reaction
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
Other sequences found for EC No. 4.1.99.17
General information:
Sequence
0 MSTTTLTRRE QRAKAQHFID TLEGTAFPNS KRIYVTGSQH DIRVPMREIQ LSPTLIGGSK
60 DNPQFEENEA VPVYDTSGPY GDPEVAINVQ QGLAKLRQPW IDARNDSEEL DDRSSAYTRE
120 RLADDGLDDL RFTGLLTPKR AKAGKRVTQL HYARKGIVTP EMEFIAIREN MGRERIRSEV
180 LRHQHPGMNF GARLPENITP EFVRDEVAAG RAIIPANINH PESEPMIIGR NFLVKVNANI
240 GNSAVTSSIE EEVEKLVWST RWGADTVMDL STGRYIHETR EWILRNSPVP IGTVPIYQAL
300 EKVNGIAEDL TWEAFRDTLL EQAEQGVDYF TIHAGVLLRY VPMTAKRLTG IVSRGGSIMA
360 KWCLSHHKEN FLFEHFREIC EICAAYDVSL SLGDGLRPGS IQDANDEAQF SELHTLGELT
420 KIAWEYDVQV MIEGPGHVPM HMIQRNMTEE LESCHEAPFY TLGPLTTDIA PGYDHFTSGI
480 GAAMIGWFGC AMLCYVTPKE HLGLPNKEDV KQGLITYKIA AHAADLAKGH PGAQIRDNAM
540 SKARFEFRWE DQFNLALDPF TARAYHDETL PQESGKVAHF CSMCGPKFCS MKISQEVRDY
600 AAAQTIEIGM ADMSEDFRAK GGEIYLKREE A
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
619849
McClelland M.,Sanderson K.E.,Spieth J.,Clifton S.W.,Latreille P.,Courtney L.,Porwollik S.,Ali J.,Dante M.,Du F.,Hou S.,Layman D.,Leonard S.,Nguyen C.,Scott K.,Holmes A.,Grewal N.,Mulvaney E.,Ryan E.,Sun H.,Florea L.,Miller W.,Stoneking T.,Nhan M.,Waterston R.,Wilson R.K.
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.
Nature
413
852-856
2001
619850
Martinez-Gomez N.C.,Poyner R.R.,Mansoorabadi S.O.,Reed G.H.,Downs D.M.
Reaction of AdoMet with ThiC generates a backbone free radical.
Biochemistry
48
217-219
2009
619851
Dougherty M.J.,Downs D.M.
A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica.
Microbiology
152
2345-2353
2006
619852
Martinez-Gomez N.C.,Downs D.M.
ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis.
Biochemistry
47
9054-9056
2008
