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Sequence of PK3CG_MOUSE

EC Number:2.7.1.137

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.7.1.137
phosphatidylinositol 3-kinase
Q9JHG7
Mus musculus
1102
126400
Swiss-Prot
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137

EC Number:2.7.1.153

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.7.1.153
phosphatidylinositol-4,5-bisphosphate 3-kinase
Q9JHG7
Mus musculus
1102
126400
Swiss-Prot
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Other sequences found for EC No. 2.7.1.153

EC Number:2.7.1.154

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.7.1.154
phosphatidylinositol-4-phosphate 3-kinase
Q9JHG7
Mus musculus
1102
126400
Swiss-Prot
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Other sequences found for EC No. 2.7.1.154

EC Number:2.7.11.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.7.11.1
non-specific serine/threonine protein kinase
Q9JHG7
Mus musculus
1102
126400
Swiss-Prot
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1

General information:

Sequence
show sequence in fasta format
   0 MELENYEQPV VLREDNLRRR RRMKPRSAAG SLSSMELIPI EFVLPTSQRI SKTPETALLH
  60 VAGHGNVEQM KAQVWLRALE TSVAAEFYHR LGPDQFLLLY QKKGQWYEIY DRYQVVQTLD
 120 CLHYWKLMHK SPGQIHVVQR HVPSEETLAF QKQLTSLIGY DVTDISNVHD DELEFTRRRL
 180 VTPRMAEVAG RDAKLYAMHP WVTSKPLPDY LSKKIANNCI FIVIHRGTTS QTIKVSADDT
 240 PGTILQSFFT KMAKKKSLMN ISESQSEQDF VLRVCGRDEY LVGETPLKNF QWVRQCLKNG
 300 DEIHLVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK
 360 FRVKIRGIDI PVLPRNTDLT VFVEANIQHG QQVLCQRRTS PKPFAEEVLW NVWLEFGIKI
 420 KDLPKGALLN LQIYCCKTPS LSSKASAETP GSESKGKAQL LYYVNLLLID HRFLLRHGDY
 480 VLHMWQISGK AEEQGSFNAD KLTSATNPDK ENSMSISILL DNYCHPIALP KHRPTPDPEG
 540 DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ
 600 QEIVAKTYQL LARREIWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL
 660 LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY
 720 LRGCGTAMLQ DFTQQVHVIE MLQKVTIDIK SLSAEKYDVS SQVISQLKQK LESLQNSNLP
 780 ESFRVPYDPG LKAGTLVIEK CKVMASKKKP LWLEFKCADP TVLSNETIGI IFKHGDDLRQ
 840 DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAQ IQQSTVGNTG
 900 AFKDEVLNHW LKEKCPIEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMISETGNL
 960 FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGSSGK KTSPHFQKFQ DVCVRAYLAL
1020 RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKS EEDAKKYFLD QIEVCRDKGW
1080 TVQFNWFLHL VLGIKQGEKH SA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
205877
Hirsch E.,Wymann M.P.,Patrucco E.,Tolosano E.,Bulgarelli-Leva G.,Marengo S.,Rocchi M.,Altruda F.
Analysis of the murine phosphoinositide 3-kinase gamma gene.
Gene
256
69-81
2000
11054537
205878
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
15489334
205880
Sasaki T.,Irie-Sasaki J.,Jones R.G.,Oliveira-dos-Santos A.J.,Stanford W.L.,Bolon B.,Wakeham A.,Itie A.,Bouchard D.,Kozieradzki I.,Joza N.,Mak T.W.,Ohashi P.S.,Suzuki A.,Penninger J.M.
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Science
287
1040-1046
2000
10669416
205881
Hirsch E.,Katanaev V.L.,Garlanda C.,Azzolino O.,Pirola L.,Silengo L.,Sozzani S.,Mantovani A.,Altruda F.,Wymann M.P.
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.
Science
287
1049-1053
2000
10669418
205882
Gu C.,Park S.
The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner.
Mol. Cell. Biol.
21
4579-4597
2001
11416136
205883
Crackower M.A.,Oudit G.Y.,Kozieradzki I.,Sarao R.,Sun H.,Sasaki T.,Hirsch E.,Suzuki A.,Shioi T.,Irie-Sasaki J.,Sah R.,Cheng H.-Y.M.,Rybin V.O.,Lembo G.,Fratta L.,Oliveira-dos-Santos A.J.,Benovic J.L.,Kahn C.R.,Izumo S.,Steinberg S.F.,Wymann M.P.,Backx P.H.,Penninger J.M.
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell
110
737-749
2002
12297047
205884
Patrucco E.,Notte A.,Barberis L.,Selvetella G.,Maffei A.,Brancaccio M.,Marengo S.,Russo G.,Azzolino O.,Rybalkin S.D.,Silengo L.,Altruda F.,Wetzker R.,Wymann M.P.,Lembo G.,Hirsch E.
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.
Cell
118
375-387
2004
15294162
205885
Del Prete A.,Vermi W.,Dander E.,Otero K.,Barberis L.,Luini W.,Bernasconi S.,Sironi M.,Santoro A.,Garlanda C.,Facchetti F.,Wymann M.P.,Vecchi A.,Hirsch E.,Mantovani A.,Sozzani S.
Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice.
EMBO J.
23
3505-3515
2004
15318168
205886
Webb L.M.C.,Vigorito E.,Wymann M.P.,Hirsch E.,Turner M.
T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.
J. Immunol.
175
2783-2787
2005
16116162
205887
Camps M.,Rueckle T.,Ji H.,Ardissone V.,Rintelen F.,Shaw J.,Ferrandi C.,Chabert C.,Gillieron C.,Francon B.,Martin T.,Gretener D.,Perrin D.,Leroy D.,Vitte P.-A.,Hirsch E.,Wymann M.P.,Cirillo R.,Schwarz M.K.,Rommel C.
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Nat. Med.
11
936-943
2005
16127437
205888
Schoenwaelder S.M.,Ono A.,Sturgeon S.,Chan S.M.,Mangin P.,Maxwell M.J.,Turnbull S.,Mulchandani M.,Anderson K.,Kauffenstein G.,Rewcastle G.W.,Kendall J.,Gachet C.,Salem H.H.,Jackson S.P.
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.
J. Biol. Chem.
282
28648-28658
2007
17673465
205889
Saudemont A.,Garcon F.,Yadi H.,Roche-Molina M.,Kim N.,Segonds-Pichon A.,Martin-Fontecha A.,Okkenhaug K.,Colucci F.
p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease.
Proc. Natl. Acad. Sci. U.S.A.
106
5795-5800
2009
19297623
205890
Kurig B.,Shymanets A.,Bohnacker T.,Prajwal X.,Brock C.,Ahmadian M.R.,Schaefer M.,Gohla A.,Harteneck C.,Wymann M.P.,Jeanclos E.,Nurnberg B.
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.
Proc. Natl. Acad. Sci. U.S.A.
106
20312-20317
2009
19906996
205891
Perino A.,Ghigo A.,Ferrero E.,Morello F.,Santulli G.,Baillie G.S.,Damilano F.,Dunlop A.J.,Pawson C.,Walser R.,Levi R.,Altruda F.,Silengo L.,Langeberg L.K.,Neubauer G.,Heymans S.,Lembo G.,Wymann M.P.,Wetzker R.,Houslay M.D.,Iaccarino G.,Scott J.D.,Hirsch E.
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110gamma.
Mol. Cell
42
84-95
2011
21474070