Sequence of GBA3_HUMAN
EC Number:3.2.1.21
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
celloheptaose + 6 H2O = 7 beta-D-glucose
Other sequences found for EC No. 3.2.1.21
EC Number:3.2.1.45
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a D-glucosyl-N-acylsphingosine + H2O = D-glucose + a ceramide
Other sequences found for EC No. 3.2.1.45
EC Number:3.2.1.46
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide
Other sequences found for EC No. 3.2.1.46
General information:
Sequence
0 MAFPAGFGWA AATAAYQVEG GWDADGKGPC VWDTFTHQGG ERVFKNQTGD VACGSYTLWE
60 EDLKCIKQLG LTHYRFSLSW SRLLPDGTTG FINQKGIDYY NKIIDDLLKN GVTPIVTLYH
120 FDLPQTLEDQ GGWLSEAIIE SFDKYAQFCF STFGDRVKQW ITINEANVLS VMSYDLGMFP
180 PGIPHFGTGG YQAAHNLIKA HARSWHSYDS LFRKKQKGMV SLSLFAVWLE PADPNSVSDQ
240 EAAKRAITFH LDLFAKPIFI DGDYPEVVKS QIASMSQKQG YPSSRLPEFT EEEKKMIKGT
300 ADFFAVQYYT TRLIKYQENK KGELGILQDA EIEFFPDPSW KNVDWIYVVP WGVCKLLKYI
360 KDTYNNPVIY ITENGFPQSD PAPLDDTQRW EYFRQTFQEL FKAIQLDKVN LQVYCAWSLL
420 DNFEWNQGYS SRFGLFHVDF EDPARPRVPY TSAKEYAKII RNNGLEAHL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
802032
Yahata K.,Mori K.,Arai H.,Koide S.,Ogawa Y.,Mukoyama M.,Sugawara A.,Ozaki S.,Tanaka I.,Nabeshima Y.,Nakao K.
Molecular cloning and expression of a novel klotho-related protein.
J. Mol. Med.
78
389-394
2000
802033
de Graaf M.,van Veen I.C.,van der Meulen-Muileman I.H.,Gerritsen W.R.,Pinedo H.M.,Haisma H.J.
Cloning and characterization of human liver cytosolic beta-glycosidase.
Biochem. J.
356
907-910
2001
802034
Berrin J.-G.,McLauchlan W.R.,Needs P.,Williamson G.,Puigserver A.,Kroon P.A.,Juge N.
Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides.
Eur. J. Biochem.
269
249-258
2002
802037
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
802038
Berrin J.-G.,Czjzek M.,Kroon P.A.,McLauchlan W.R.,Puigserver A.,Williamson G.,Juge N.
Substrate (aglycone) specificity of human cytosolic beta-glucosidase.
Biochem. J.
373
41-48
2003
802039
Nemeth K.,Plumb G.W.,Berrin J.-G.,Juge N.,Jacob R.,Naim H.Y.,Williamson G.,Swallow D.M.,Kroon P.A.
Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.
Eur. J. Nutr.
42
29-42
2003
802040
Dekker N.,Voorn-Brouwer T.,Verhoek M.,Wennekes T.,Narayan R.S.,Speijer D.,Hollak C.E.,Overkleeft H.S.,Boot R.G.,Aerts J.M.
The cytosolic beta-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation.
Blood Cells Mol. Dis.
46
19-26
2011
802041
Wang L.,Seino J.,Tomotake H.,Funakoshi Y.,Hirayama H.,Suzuki T.
Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3.
Biomolecules
5
1499-1514
2015
802042
Marques A.R.,Mirzaian M.,Akiyama H.,Wisse P.,Ferraz M.J.,Gaspar P.,Ghauharali-van der Vlugt K.,Meijer R.,Giraldo P.,Alfonso P.,Irun P.,Dahl M.,Karlsson S.,Pavlova E.V.,Cox T.M.,Scheij S.,Verhoek M.,Ottenhoff R.,van Roomen C.P.,Pannu N.S.,van Eijk M.,Dekker N.,Boot R.G.,Overkleeft H.S.,Blommaart E.,Hirabayashi Y.,Aerts J.M.
Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular beta-glucosidases.
J. Lipid Res.
57
451-463
2016
802043
Boer D.E.,Mirzaian M.,Ferraz M.J.,Zwiers K.C.,Baks M.V.,Hazeu M.D.,Ottenhoff R.,Marques A.R.A.,Meijer R.,Roos J.C.P.,Cox T.M.,Boot R.G.,Pannu N.,Overkleeft H.S.,Artola M.,Aerts J.M.
Human glucocerebrosidase mediates formation of xylosyl-cholesterol by beta-xylosidase and transxylosidase reactions.
J. Lipid Res.
62
100018-100018
2021
802044
Hayashi Y.,Okino N.,Kakuta Y.,Shikanai T.,Tani M.,Narimatsu H.,Ito M.
Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase.
J. Biol. Chem.
282
30889-30900
2007
802045
Tribolo S.,Berrin J.G.,Kroon P.A.,Czjzek M.,Juge N.
The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase.
J. Mol. Biol.
370
964-975
2007
802046
Noguchi J.,Hayashi Y.,Baba Y.,Okino N.,Kimura M.,Ito M.,Kakuta Y.
Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase.
Biochem. Biophys. Res. Commun.
374
549-552
2008
802047
Beutler E.,Beutler L.,West C.
Mutations in the gene encoding cytosolic beta-glucosidase in Gaucher disease.
J. Lab. Clin. Med.
144
65-68
2004
