Sequence of XYLT2_HUMAN
EC Number:2.4.2.26
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
UDP-alpha-D-xylose + [protein]-L-serine = UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
Other sequences found for EC No. 2.4.2.26
General information:
Sequence
0 MVASARVQKL VRRYKLAIAT ALAILLLQGL VVWSFSGLEE DEAGEKGRQR KPRPLDPGEG
60 SKDTDSSAGR RGSTGRRHGR WRGRAESPGV PVAKVVRAVT SRQRASRRVP PAPPPEAPGR
120 QNLSGAAAGE ALVGAAGFPP HGDTGSVEGA PQPTDNGFTP KCEIVGKDAL SALARASTKQ
180 CQQEIANVVC LHQAGSLMPK AVPRHCQLTG KMSPGIQWDE SQAQQPMDGP PVRIAYMLVV
240 HGRAIRQLKR LLKAVYHEQH FFYIHVDKRS DYLHREVVEL AQGYDNVRVT PWRMVTIWGG
300 ASLLRMYLRS MRDLLEVPGW AWDFFINLSA TDYPTRTNEE LVAFLSKNRD KNFLKSHGRD
360 NSRFIKKQGL DRLFHECDSH MWRLGERQIP AGIVVDGGSD WFVLTRSFVE YVVYTDDPLV
420 AQLRQFYTYT LLPAESFFHT VLENSLACET LVDNNLRVTN WNRKLGCKCQ YKHIVDWCGC
480 SPNDFKPQDF LRLQQVSRPT FFARKFESTV NQEVLEILDF HLYGSYPPGT PALKAYWENT
540 YDAADGPSGL SDVMLTAYTA FARLSLHHAA TAAPPMGTPL CRFEPRGLPS SVHLYFYDDH
600 FQGYLVTQAV QPSAQGPAET LEMWLMPQGS LKLLGRSDQA SRLQSLEVGT DWDPKERLFR
660 NFGGLLGPLD EPVAVQRWAR GPNLTATVVW IDPTYVVATS YDITVDTETE VTQYKPPLSR
720 PLRPGPWTVR LLQFWEPLGE TRFLVLPLTF NRKLPLRKDD ASWLHAGPPH NEYMEQSFQG
780 LSSILNLPQP ELAEEAAQRH TQLTGPALEA WTDRELSSFW SVAGLCAIGP SPCPSLEPCR
840 LTSWSSLSPD PKSELGPVKA DGRLR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
502107
Goetting C.,Kuhn J.,Zahn R.,Brinkmann T.,Kleesiek K.
Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase and its first isoform XT-II.
J. Mol. Biol.
304
517-528
2000
502108
Clark H.F.,Gurney A.L.,Abaya E.,Baker K.,Baldwin D.T.,Brush J.,Chen J.,Chow B.,Chui C.,Crowley C.,Currell B.,Deuel B.,Dowd P.,Eaton D.,Foster J.S.,Grimaldi C.,Gu Q.,Hass P.E.,Heldens S.,Huang A.,Kim H.S.,Klimowski L.,Jin Y.,Johnson S.,Lee J.,Lewis L.,Liao D.,Mark M.R.,Robbie E.,Sanchez C.,Schoenfeld J.,Seshagiri S.,Simmons L.,Singh J.,Smith V.,Stinson J.,Vagts A.,Vandlen R.L.,Watanabe C.,Wieand D.,Woods K.,Xie M.-H.,Yansura D.G.,Yi S.,Yu G.,Yuan J.,Zhang M.,Zhang Z.,Goddard A.D.,Wood W.I.,Godowski P.J.,Gray A.M.
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome Res.
13
2265-2270
2003
502109
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
502110
Schon S.,Schulz V.,Prante C.,Hendig D.,Szliska C.,Kuhn J.,Kleesiek K.,Gotting C.
Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course.
J. Med. Genet.
43
745-749
2006
502111
Poenighaus C.,Ambrosius M.,Casanova J.C.,Prante C.,Kuhn J.,Esko J.D.,Kleesiek K.,Goetting C.
Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans.
J. Biol. Chem.
282
5201-5206
2007
502112
Casanova J.C.,Kuhn J.,Kleesiek K.,Goetting C.
Heterologous expression and biochemical characterization of soluble human xylosyltransferase II.
Biochem. Biophys. Res. Commun.
365
678-684
2008
502113
Munns C.F.,Fahiminiya S.,Poudel N.,Munteanu M.C.,Majewski J.,Sillence D.O.,Metcalf J.P.,Biggin A.,Glorieux F.,Fassier F.,Rauch F.,Hinsdale M.E.
Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.
Am. J. Hum. Genet.
96
971-978
2015
502114
Kuhn J.,Goetting C.,Beahm B.J.,Bertozzi C.R.,Faust I.,Kuzaj P.,Knabbe C.,Hendig D.
Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum.
Biochem. Biophys. Res. Commun.
459
469-474
2015
