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Sequence of DHRS4_HUMAN

EC Number:1.1.1.184

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
carbonyl reductase (NADPH)
Q9BTZ2
Homo sapiens
278
29537
Reaction
R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+
Other sequences found for EC No. 1.1.1.184

EC Number:1.1.1.300

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
NADP-retinol dehydrogenase
Q9BTZ2
Homo sapiens
278
29537
Reaction
retinol + NADP+ = retinal + NADPH + H+
Other sequences found for EC No. 1.1.1.300

General information:

Sequence
show sequence in fasta format
  0 MHKAGLLGLC ARAWNSVRMA SSGMTRRDPL ANKVALVTAS TDGIGFAIAR RLAQDGAHVV
 60 VSSRKQQNVD QAVATLQGEG LSVTGTVCHV GKAEDRERLV ATAVKLHGGI DILVSNAAVN
120 PFFGSIMDVT EEVWDKTLDI NVKAPALMTK AVVPEMEKRG GGSVVIVSSI AAFSPSPGFS
180 PYNVSKTALL GLTKTLAIEL APRNIRVNCL APGLIKTSFS RMLWMDKEKE ESMKETLRIR
240 RLGEPEDCAG IVSFLCSEDA SYITGETVVV GGGTPSRL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
284400
Fransen M.,Van Veldhoven P.P.,Subramani S.
Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase.
Biochem. J.
340
561-568
1999
284402
Du J.,Huang D.-Y.,Liu G.-F.,Wang G.-L.,Xu X.-L.,Wang B.,Zhu L.
cDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics.
Yi Chuan Xue Bao
31
661-667
2004
284406
Song X.-H.,Liang B.,Liu G.-F.,Li R.,Xie J.-P.,Du K.,Huang D.-Y.
Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.
Int. J. Cancer
120
1618-1626
2007
284407
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
284408
Clark H.F.,Gurney A.L.,Abaya E.,Baker K.,Baldwin D.T.,Brush J.,Chen J.,Chow B.,Chui C.,Crowley C.,Currell B.,Deuel B.,Dowd P.,Eaton D.,Foster J.S.,Grimaldi C.,Gu Q.,Hass P.E.,Heldens S.,Huang A.,Kim H.S.,Klimowski L.,Jin Y.,Johnson S.,Lee J.,Lewis L.,Liao D.,Mark M.R.,Robbie E.,Sanchez C.,Schoenfeld J.,Seshagiri S.,Simmons L.,Singh J.,Smith V.,Stinson J.,Vagts A.,Vandlen R.L.,Watanabe C.,Wieand D.,Woods K.,Xie M.-H.,Yansura D.G.,Yi S.,Yu G.,Yuan J.,Zhang M.,Zhang Z.,Goddard A.D.,Wood W.I.,Godowski P.J.,Gray A.M.
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome Res.
13
2265-2270
2003
284409
Heilig R.,Eckenberg R.,Petit J.-L.,Fonknechten N.,Da Silva C.,Cattolico L.,Levy M.,Barbe V.,De Berardinis V.,Ureta-Vidal A.,Pelletier E.,Vico V.,Anthouard V.,Rowen L.,Madan A.,Qin S.,Sun H.,Du H.,Pepin K.,Artiguenave F.,Robert C.,Cruaud C.,Bruels T.,Jaillon O.,Friedlander L.,Samson G.,Brottier P.,Cure S.,Segurens B.,Aniere F.,Samain S.,Crespeau H.,Abbasi N.,Aiach N.,Boscus D.,Dickhoff R.,Dors M.,Dubois I.,Friedman C.,Gouyvenoux M.,James R.,Madan A.,Mairey-Estrada B.,Mangenot S.,Martins N.,Menard M.,Oztas S.,Ratcliffe A.,Shaffer T.,Trask B.,Vacherie B.,Bellemere C.,Belser C.,Besnard-Gonnet M.,Bartol-Mavel D.,Boutard M.,Briez-Silla S.,Combette S.,Dufosse-Laurent V.,Ferron C.,Lechaplais C.,Louesse C.,Muselet D.,Magdelenat G.,Pateau E.,Petit E.,Sirvain-Trukniewicz P.,Trybou A.,Vega-Czarny N.,Bataille E.,Bluet E.,Bordelais I.,Dubois M.,Dumont C.,Guerin T.,Haffray S.,Hammadi R.,Muanga J.,Pellouin V.,Robert D.,Wunderle E.,Gauguet G.,Roy A.,Sainte-Marthe L.,Verdier J.,Verdier-Discala C.,Hillier L.W.,Fulton L.,McPherson J.,Matsuda F.,Wilson R.,Scarpelli C.,Gyapay G.,Wincker P.,Saurin W.,Quetier F.,Waterston R.,Hood L.,Weissenbach J.
The DNA sequence and analysis of human chromosome 14.
Nature
421
601-607
2003
284410
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
284411
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
284412
Matsunaga T.,Endo S.,Maeda S.,Ishikura S.,Tajima K.,Tanaka N.,Nakamura K.T.,Imamura Y.,Hara A.
Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity.
Arch. Biochem. Biophys.
477
339-347
2008
284413
Endo S.,Maeda S.,Matsunaga T.,Dhagat U.,El-Kabbani O.,Tanaka N.,Nakamura K.T.,Tajima K.,Hara A.
Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4).
Arch. Biochem. Biophys.
481
183-190
2009
284414
Persson B.,Kallberg Y.,Bray J.E.,Bruford E.,Dellaporta S.L.,Favia A.D.,Duarte R.G.,Joernvall H.,Kavanagh K.L.,Kedishvili N.,Kisiela M.,Maser E.,Mindnich R.,Orchard S.,Penning T.M.,Thornton J.M.,Adamski J.,Oppermann U.
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
Chem. Biol. Interact.
178
94-98
2009
284415
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
284416
Yan Y.,Song X.,Liu G.,Su Z.,Du Y.,Sui X.,Chang X.,Huang D.
Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of Benzil.
Cell. Physiol. Biochem.
30
1371-1382
2012
284417
Su Z.,Li R.,Song X.,Liu G.,Li Y.,Chang X.,Li C.,Huang D.
Identification of a novel isoform of DHRS4 protein with a nuclear localization signal.
Gene
494
161-167
2012
284418
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
284419
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
284420
Su Z.,Liu G.,Song X.,Liang B.,Chang X.,Huang D.
CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.
Genet. Mol. Res.
15
0-0
2016