Sequence of THIC_CAUVC
EC Number:4.1.99.17
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phosphomethylpyrimidine synthase
Q9A6Q5
Caulobacter vibrioides (strain ATCC 19089 / CB15)
612
67968
Reaction
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
Other sequences found for EC No. 4.1.99.17
General information:
Sequence
0 MNIQSTIKAV AETISTGPIP GSRKVYQAGE LFPELRVPFR EVAVHPSANE PPVTIYDPSG
60 PYSDPAIQID IEKGLPRTRE ALVVARGDVE EVADPRQVKP EDNGFAQGKH LAPEFPDTGR
120 KIYRAKPGKL VTQLEYARAG IITAEMEYVA IRENLRREQD RPCVRDGEDF GASIPDFVTP
180 EFVRQEIARG RAIIPANINH GELEPMAIGR NFLVKINANI GNSAVLSTVA DEVDKLVWAT
240 RWGADTVMDL STGRNIHNIR DWIIRNSSVP IGTVPIYQAL EKVNGVAEDL NWEVFRDTLI
300 EQCEQGVDYF TIHAGVRLPF IPMTAKRVTG IVSRGGSIMA KWCLAHHKEN FLYERFDEIC
360 EIMRAYDVSF SLGDGLRPGS TADANDEAQF SELRTLGELT KVAWKHGVQV MIEGPGHVAM
420 HKIKANMDEQ LKHCHEAPFY TLGPLTTDIA PGYDHITSAI GAAMIGWFGT AMLCYVTPKE
480 HLGLPDRDDV KTGVITYKLA AHAADLAKGH PGAAMWDDAI SRARFEFRWE DQFNLGLDPE
540 TARKFHDETL PKEAHKTAHF CSMCGPKFCS MKISQEVRDF AAGKAPNSAE LGMAEMSEKF
600 REQGSEIYLK TE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
367000
Nierman W.C.,Feldblyum T.V.,Laub M.T.,Paulsen I.T.,Nelson K.E.,Eisen J.A.,Heidelberg J.F.,Alley M.R.K.,Ohta N.,Maddock J.R.,Potocka I.,Nelson W.C.,Newton A.,Stephens C.,Phadke N.D.,Ely B.,DeBoy R.T.,Dodson R.J.,Durkin A.S.,Gwinn M.L.,Haft D.H.,Kolonay J.F.,Smit J.,Craven M.B.,Khouri H.M.,Shetty J.,Berry K.J.,Utterback T.R.,Tran K.,Wolf A.M.,Vamathevan J.J.,Ermolaeva M.D.,White O.,Salzberg S.L.,Venter J.C.,Shapiro L.,Fraser C.M.
Complete genome sequence of Caulobacter crescentus.
Proc. Natl. Acad. Sci. U.S.A.
98
4136-4141
2001
367001
Chatterjee A.,Hazra A.B.,Abdelwahed S.,Hilmey D.G.,Begley T.P.
A 'radical dance' in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase.
Angew. Chem. Int. Ed.
49
8653-8656
2010
367002
Chatterjee A.,Li Y.,Zhang Y.,Grove T.L.,Lee M.,Krebs C.,Booker S.J.,Begley T.P.,Ealick S.E.
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
Nat. Chem. Biol.
4
758-765
2008
367003
Fenwick M.K.,Mehta A.P.,Zhang Y.,Abdelwahed S.H.,Begley T.P.,Ealick S.E.
Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase.
Nat. Commun.
6
6480-6480
2015
