Sequence of TETX_BACT4
EC Number:1.14.13.231
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.13.231
General information:
Sequence
0 MTMRIDTDKQ MNLLSDKNVA IIGGGPVGLT MAKLLQQNGI DVSVYERDND REARIFGGTL
60 DLHKGSGQEA MKKAGLLQTY YDLALPMGVN IADEKGNILS TKNVKPENRF DNPEINRNDL
120 RAILLNSLEN DTVIWDRKLV MLEPGKKKWT LTFENKPSET ADLVILANGG MSKVRKFVTD
180 TEVEETGTFN IQADIHQPEI NCPGFFQLCN GNRLMASHQG NLLFANPNNN GALHFGISFK
240 TPDEWKNQTQ VDFQNRNSVV DFLLKEFSDW DERYKELIHT TLSFVGLATR IFPLEKPWKS
300 KRPLPITMIG DAAHLMPPFA GQGVNSGLVD ALILSDNLAD GKFNSIEEAV KNYEQQMFIY
360 GKEAQEESTQ NEIEMFKPDF TFQQLLNV
Download this sequence
in fasta formatDownload all sequences for 1.14.13.231
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
619222
Whittle G.,Hund B.D.,Shoemaker N.B.,Salyers A.A.
Characterization of the 13-kilobase ermF region of the Bacteroides conjugative transposon CTnDOT.
Appl. Environ. Microbiol.
67
3488-3495
2001
619223
Yang W.,Moore I.F.,Koteva K.P.,Bareich D.C.,Hughes D.W.,Wright G.D.
TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics.
J. Biol. Chem.
279
52346-52352
2004
619224
Moore I.F.,Hughes D.W.,Wright G.D.
Tigecycline is modified by the flavin-dependent monooxygenase TetX.
Biochemistry
44
11829-11835
2005
619225
Forsberg K.J.,Patel S.,Wencewicz T.A.,Dantas G.
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
Chem. Biol.
22
888-897
2015
619226
Park J.,Gasparrini A.J.,Reck M.R.,Symister C.T.,Elliott J.L.,Vogel J.P.,Wencewicz T.A.,Dantas G.,Tolia N.H.
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol.
13
730-736
2017
619227
Volkers G.,Palm G.J.,Weiss M.S.,Wright G.D.,Hinrichs W.
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase.
FEBS Lett.
585
1061-1066
2011
619228
Walkiewicz K.,Davlieva M.,Wu G.,Shamoo Y.
Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution.
Proteins
79
2335-2340
2011
619229
Walkiewicz K.,Benitez Cardenas A.S.,Sun C.,Bacorn C.,Saxer G.,Shamoo Y.
Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance.
Proc. Natl. Acad. Sci. U.S.A.
109
21408-21413
2012
619231
Volkers G.,Damas J.M.,Palm G.J.,Panjikar S.,Soares C.M.,Hinrichs W.
Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX.
Acta Crystallogr. D
69
1758-1767
2013
