Sequence of HDAC2_HUMAN
EC Number:3.5.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 3.5.1
EC Number:3.5.1.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Other sequences found for EC No. 3.5.1.98
General information:
Sequence
0 MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA
60 TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA
120 GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH
180 GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ
240 IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG
300 GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM
360 EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE
420 FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT
480 KSEQLSNP
Download this sequence
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1067430
Yang W.-M.,Inouye C.J.,Zeng Y.,Bearss D.,Seto E.
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.
Proc. Natl. Acad. Sci. U.S.A.
93
12845-12850
1996
1067431
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
1067432
Mungall A.J.,Palmer S.A.,Sims S.K.,Edwards C.A.,Ashurst J.L.,Wilming L.,Jones M.C.,Horton R.,Hunt S.E.,Scott C.E.,Gilbert J.G.R.,Clamp M.E.,Bethel G.,Milne S.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews T.D.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beare D.M.,Beasley H.,Beasley O.,Bird C.P.,Blakey S.E.,Bray-Allen S.,Brook J.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clark G.,Clee C.M.,Clegg S.,Cobley V.,Collier R.E.,Collins J.E.,Colman L.K.,Corby N.R.,Coville G.J.,Culley K.M.,Dhami P.,Davies J.,Dunn M.,Earthrowl M.E.,Ellington A.E.,Evans K.A.,Faulkner L.,Francis M.D.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Ghori M.J.,Gilby L.M.,Gillson C.J.,Glithero R.J.,Grafham D.V.,Grant M.,Gribble S.,Griffiths C.,Griffiths M.N.D.,Hall R.,Halls K.S.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Heathcott R.,Holmes S.J.,Howden P.J.,Howe K.L.,Howell G.R.,Huckle E.,Humphray S.J.,Humphries M.D.,Hunt A.R.,Johnson C.M.,Joy A.A.,Kay M.,Keenan S.J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.R.,Lloyd D.M.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Maslen G.L.,Matthews L.,McCann O.T.,McLaren S.J.,McLay K.,McMurray A.,Moore M.J.F.,Mullikin J.C.,Niblett D.,Nickerson T.,Novik K.L.,Oliver K.,Overton-Larty E.K.,Parker A.,Patel R.,Pearce A.V.,Peck A.I.,Phillimore B.J.C.T.,Phillips S.,Plumb R.W.,Porter K.M.,Ramsey Y.,Ranby S.A.,Rice C.M.,Ross M.T.,Searle S.M.,Sehra H.K.,Sheridan E.,Skuce C.D.,Smith S.,Smith M.,Spraggon L.,Squares S.L.,Steward C.A.,Sycamore N.,Tamlyn-Hall G.,Tester J.,Theaker A.J.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,White S.S.,Whitehead S.L.,Whittaker H.,Wild A.,Willey D.J.,Wilmer T.E.,Wood J.M.,Wray P.W.,Wyatt J.C.,Young L.,Younger R.M.,Bentley D.R.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Dunham I.,Rogers J.,Beck S.
The DNA sequence and analysis of human chromosome 6.
Nature
425
805-811
2003
1067434
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1067435
Schmidt D.R.,Schreiber S.L.
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.
Biochemistry
38
14711-14717
1999
1067436
Zhou S.,Fujimuro M.,Hsieh J.J.,Chen L.,Hayward S.D.
A role for SKIP in EBNA2 activation of CBF1-repressed promoters.
J. Virol.
74
1939-1947
2000
1067437
Rountree M.R.,Bachman K.E.,Baylin S.B.
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
Nat. Genet.
25
269-277
2000
1067438
Ahringer J.
NuRD and SIN3 histone deacetylase complexes in development.
Trends Genet.
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351-356
2000
1067439
Shi Y.,Downes M.,Xie W.,Kao H.-Y.,Ordentlich P.,Tsai C.-C.,Hon M.,Evans R.M.
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
Genes Dev.
15
1140-1151
2001
1067440
Amann J.M.,Nip J.,Strom D.K.,Lutterbach B.,Harada H.,Lenny N.,Downing J.R.,Meyers S.,Hiebert S.W.
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Mol. Cell. Biol.
21
6470-6483
2001
1067441
Fischer D.D.,Cai R.,Bhatia U.,Asselbergs F.A.M.,Song C.,Terry R.,Trogani N.,Widmer R.,Atadja P.,Cohen D.
Isolation and characterization of a novel class II histone deacetylase, HDAC10.
J. Biol. Chem.
277
6656-6666
2002
1067442
Sun J.M.,Chen H.Y.,Moniwa M.,Litchfield D.W.,Seto E.,Davie J.R.
The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.
J. Biol. Chem.
277
35783-35786
2002
1067443
Hollenbach A.D.,McPherson C.J.,Mientjes E.J.,Iyengar R.,Grosveld G.
Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
J. Cell Sci.
115
3319-3330
2002
1067444
Bereshchenko O.R.,Gu W.,Dalla-Favera R.
Acetylation inactivates the transcriptional repressor BCL6.
Nat. Genet.
32
606-613
2002
1067445
Bhakat K.K.,Izumi T.,Yang S.H.,Hazra T.K.,Mitra S.
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
EMBO J.
22
6299-6309
2003
1067446
Wysocka J.,Myers M.P.,Laherty C.D.,Eisenman R.N.,Herr W.
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.
Genes Dev.
17
896-911
2003
1067447
Hakimi M.-A.,Dong Y.,Lane W.S.,Speicher D.W.,Shiekhattar R.
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.
J. Biol. Chem.
278
7234-7239
2003
1067448
Fleischer T.C.,Yun U.J.,Ayer D.E.
Identification and characterization of three new components of the mSin3A corepressor complex.
Mol. Cell. Biol.
23
3456-3467
2003
1067449
Choi Y.B.,Ko J.K.,Shin J.
The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains.
J. Biol. Chem.
279
50930-50941
2004
1067450
Castet A.,Boulahtouf A.,Versini G.,Bonnet S.,Augereau P.,Vignon F.,Khochbin S.,Jalaguier S.,Cavailles V.
Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.
Nucleic Acids Res.
32
1957-1966
2004
1067451
Gray S.G.,Iglesias A.H.,Lizcano F.,Villanueva R.,Camelo S.,Jingu H.,Teh B.T.,Koibuchi N.,Chin W.W.,Kokkotou E.,Dangond F.
Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.
J. Biol. Chem.
280
28507-28518
2005
1067452
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
1067453
Viiri K.M.,Korkeamaeki H.,Kukkonen M.K.,Nieminen L.K.,Lindfors K.,Peterson P.,Maeki M.,Kainulainen H.,Lohi O.
SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.
Nucleic Acids Res.
34
3288-3298
2006
1067454
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
1067455
Mulligan P.,Westbrook T.F.,Ottinger M.,Pavlova N.,Chang B.,Macia E.,Shi Y.J.,Barretina J.,Liu J.,Howley P.M.,Elledge S.J.,Shi Y.
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
Mol. Cell
32
718-726
2008
1067456
Mendez L.M.,Polo J.M.,Yu J.J.,Krupski M.,Ding B.B.,Melnick A.,Ye B.H.
CtBP is an essential corepressor for BCL6 autoregulation.
Mol. Cell. Biol.
28
2175-2186
2008
1067457
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
1067458
Zhao W.M.,Coppinger J.A.,Seki A.,Cheng X.L.,Yates J.R. III,Fang G.
RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.
Proc. Natl. Acad. Sci. U.S.A.
105
13415-13420
2008
1067459
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
1067460
Rashid S.,Pilecka I.,Torun A.,Olchowik M.,Bielinska B.,Miaczynska M.
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
J. Biol. Chem.
284
18115-18128
2009
1067461
Kajiwara Y.,Akram A.,Katsel P.,Haroutunian V.,Schmeidler J.,Beecham G.,Haines J.L.,Pericak-Vance M.A.,Buxbaum J.D.
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.
PLoS ONE
4
0-0
2009
1067462
Oh Y.M.,Kwon Y.E.,Kim J.M.,Bae S.J.,Lee B.K.,Yoo S.J.,Chung C.H.,Deshaies R.J.,Seol J.H.
Chfr is linked to tumour metastasis through the downregulation of HDAC1.
Nat. Cell Biol.
11
295-302
2009
1067463
Hait N.C.,Allegood J.,Maceyka M.,Strub G.M.,Harikumar K.B.,Singh S.K.,Luo C.,Marmorstein R.,Kordula T.,Milstien S.,Spiegel S.
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Science
325
1254-1257
2009
1067464
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
1067465
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
1067466
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1067467
Cong L.,Pakala S.B.,Ohshiro K.,Li D.Q.,Kumar R.
SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.
J. Biol. Chem.
286
43793-43808
2011
1067468
Sathyan K.M.,Shen Z.,Tripathi V.,Prasanth K.V.,Prasanth S.G.
A BEN-domain-containing protein associates with heterochromatin and represses transcription.
J. Cell Sci.
124
3149-3163
2011
1067469
Rowbotham S.P.,Barki L.,Neves-Costa A.,Santos F.,Dean W.,Hawkes N.,Choudhary P.,Will W.R.,Webster J.,Oxley D.,Green C.M.,Varga-Weisz P.,Mermoud J.E.
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
Mol. Cell
42
285-296
2011
1067470
Hao Y.,Xu N.,Box A.C.,Schaefer L.,Kannan K.,Zhang Y.,Florens L.,Seidel C.,Washburn M.P.,Wiegraebe W.,Mak H.Y.
Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.
PLoS Genet.
7
0-0
2011
1067471
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
1067472
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
1067473
Xuan C.,Wang Q.,Han X.,Duan Y.,Li L.,Shi L.,Wang Y.,Shan L.,Yao Z.,Shang Y.
RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.
Oncogene
32
3711-3721
2013
1067474
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
1067475
Hendriks I.A.,D'Souza R.C.,Yang B.,Verlaan-de Vries M.,Mann M.,Vertegaal A.C.
Uncovering global SUMOylation signaling networks in a site-specific manner.
Nat. Struct. Mol. Biol.
21
927-936
2014
1067476
Liu J.,Xu D.,Wang H.,Zhang Y.,Chang Y.,Zhang J.,Wang J.,Li C.,Liu H.,Zhao M.,Lin C.,Zhan Q.,Huang C.,Qian H.
The subcellular distribution and function of MTA1 in cancer differentiation.
Oncotarget
5
5153-5164
2014
1067477
Hendriks I.A.,Treffers L.W.,Verlaan-de Vries M.,Olsen J.V.,Vertegaal A.C.
SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
Cell Rep.
10
1778-1791
2015
1067478
Xiao Z.,Chang J.G.,Hendriks I.A.,Sigurdsson J.O.,Olsen J.V.,Vertegaal A.C.
System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
Mol. Cell. Proteomics
14
1419-1434
2015
1067479
Wei W.,Liu X.,Chen J.,Gao S.,Lu L.,Zhang H.,Ding G.,Wang Z.,Chen Z.,Shi T.,Li J.,Yu J.,Wong J.
Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.
Cell Res.
27
898-915
2017
1067480
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
1067481
Huang H.,Luo Z.,Qi S.,Huang J.,Xu P.,Wang X.,Gao L.,Li F.,Wang J.,Zhao W.,Gu W.,Chen Z.,Dai L.,Dai J.,Zhao Y.
Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.
Cell Res.
28
111-125
2018
1067482
Yu Z.,Feng J.,Wang W.,Deng Z.,Zhang Y.,Xiao L.,Wang Z.,Liu C.,Liu Q.,Chen S.,Wu M.
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
Oncogene
39
3163-3178
2020
1067483
Bressi J.C.,Jennings A.J.,Skene R.,Wu Y.,Melkus R.,De Jong R.,O'Connell S.,Grimshaw C.E.,Navre M.,Gangloff A.R.
Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.
Bioorg. Med. Chem. Lett.
20
3142-3145
2010
