Sequence of PK3C3_HUMAN
EC Number:2.7.1.137
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Other sequences found for EC No. 2.7.1.137
General information:
Sequence
0 MGEAEKFHYI YSCDLDINVQ LKIGSLEGKR EQKSYKAVLE DPMLKFSGLY QETCSDLYVT
60 CQVFAEGKPL ALPVRTSYKA FSTRWNWNEW LKLPVKYPDL PRNAQVALTI WDVYGPGKAV
120 PVGGTTVSLF GKYGMFRQGM HDLKVWPNVE ADGSEPTKTP GRTSSTLSED QMSRLAKLTK
180 AHRQGHMVKV DWLDRLTFRE IEMINESEKR SSNFMYLMVE FRCVKCDDKE YGIVYYEKDG
240 DESSPILTSF ELVKVPDPQM SMENLVESKH HKLARSLRSG PSDHDLKPNA ATRDQLNIIV
300 SYPPTKQLTY EEQDLVWKFR YYLTNQEKAL TKFLKCVNWD LPQEAKQALE LLGKWKPMDV
360 EDSLELLSSH YTNPTVRRYA VARLRQADDE DLLMYLLQLV QALKYENFDD IKNGLEPTKK
420 DSQSSVSENV SNSGINSAEI DSSQIITSPL PSVSSPPPAS KTKEVPDGEN LEQDLCTFLI
480 SRACKNSTLA NYLYWYVIVE CEDQDTQQRD PKTHEMYLNV MRRFSQALLK GDKSVRVMRS
540 LLAAQQTFVD RLVHLMKAVQ RESGNRKKKN ERLQALLGDN EKMNLSDVEL IPLPLEPQVK
600 IRGIIPETAT LFKSALMPAQ LFFKTEDGGK YPVIFKHGDD LRQDQLILQI ISLMDKLLRK
660 ENLDLKLTPY KVLATSTKHG FMQFIQSVPV AEVLDTEGSI QNFFRKYAPS ENGPNGISAE
720 VMDTYVKSCA GYCVITYILG VGDRHLDNLL LTKTGKLFHI DFGYILGRDP KPLPPPMKLN
780 KEMVEGMGGT QSEQYQEFRK QCYTAFLHLR RYSNLILNLF SLMVDANIPD IALEPDKTVK
840 KVQDKFRLDL SDEEAVHYMQ SLIDESVHAL FAAVVEQIHK FAQYWRK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
586858
Volinia S.,Dhand R.,Vanhaesebroeck B.,MacDougall L.K.,Zvelebil M.J.,Domin J.,Panaretou C.,Waterfield M.D.
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.
EMBO J.
14
3339-3348
1995
586859
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
586860
Stein M.P.,Feng Y.,Cooper K.L.,Welford A.M.,Wandinger-Ness A.
Human VPS34 and p150 are Rab7 interacting partners.
Traffic
4
754-771
2003
586861
Weiner O.D.,Rentel M.C.,Ott A.,Brown G.E.,Jedrychowski M.,Yaffe M.B.,Gygi S.P.,Cantley L.C.,Bourne H.R.,Kirschner M.W.
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
PLoS Biol.
4
0-0
2006
586862
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
586863
Sun Q.,Fan W.,Chen K.,Ding X.,Chen S.,Zhong Q.
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Proc. Natl. Acad. Sci. U.S.A.
105
19211-19216
2008
586864
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
586865
Thoresen S.B.,Pedersen N.M.,Liestol K.,Stenmark H.
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
Exp. Cell Res.
316
3368-3378
2010
586866
Matsunaga K.,Saitoh T.,Tabata K.,Omori H.,Satoh T.,Kurotori N.,Maejima I.,Shirahama-Noda K.,Ichimura T.,Isobe T.,Akira S.,Noda T.,Yoshimori T.
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
Nat. Cell Biol.
11
385-396
2009
586867
Sagona A.P.,Nezis I.P.,Pedersen N.M.,Liestol K.,Poulton J.,Rusten T.E.,Skotheim R.I.,Raiborg C.,Stenmark H.
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.
Nat. Cell Biol.
12
362-371
2010
586868
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
586869
Ma C.,Wang N.,Detre C.,Wang G.,O'Keeffe M.,Terhorst C.
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
J. Biol. Chem.
287
18359-18365
2012
586870
He C.,Wei Y.,Sun K.,Li B.,Dong X.,Zou Z.,Liu Y.,Kinch L.N.,Khan S.,Sinha S.,Xavier R.J.,Grishin N.V.,Xiao G.,Eskelinen E.L.,Scherer P.E.,Whistler J.L.,Levine B.
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
Cell
154
1085-1099
2013
586871
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
586872
Fogel A.I.,Dlouhy B.J.,Wang C.,Ryu S.W.,Neutzner A.,Hasson S.A.,Sideris D.P.,Abeliovich H.,Youle R.J.
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.
Mol. Cell. Biol.
33
3675-3688
2013
586873
Baskaran S.,Carlson L.A.,Stjepanovic G.,Young L.N.,Kim do J.,Grob P.,Stanley R.E.,Nogales E.,Hurley J.H.
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.
Elife
3
0-0
2014
586874
Miao G.,Zhang Y.,Chen D.,Zhang H.
The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.
Mol. Cell
0
0-0
2019
586875
Zhang B.C.,Nandakumar R.,Reinert L.S.,Huang J.,Laustsen A.,Gao Z.L.,Sun C.L.,Jensen S.B.,Troldborg A.,Assil S.,Berthelsen M.F.,Scavenius C.,Zhang Y.,Windross S.J.,Olagnier D.,Prabakaran T.,Bodda C.,Narita R.,Cai Y.,Zhang C.G.,Stenmark H.,Doucet C.M.,Noda T.,Guo Z.,Goldbach-Mansky R.,Hartmann R.,Chen Z.J.,Enghild J.J.,Bak R.O.,Thomsen M.K.,Paludan S.R.
STEEP mediates STING ER exit and activation of signaling.
Nat. Immunol.
21
868-879
2020
586876
Zhang B.C.,Nandakumar R.,Reinert L.S.,Huang J.,Laustsen A.,Gao Z.L.,Sun C.L.,Jensen S.B.,Troldborg A.,Assil S.,Berthelsen M.F.,Scavenius C.,Zhang Y.,Windross S.J.,Olagnier D.,Prabakaran T.,Bodda C.,Narita R.,Cai Y.,Zhang C.G.,Stenmark H.,Doucet C.M.,Noda T.,Guo Z.,Goldbach-Mansky R.,Hartmann R.,Chen Z.J.,Enghild J.J.,Bak R.O.,Thomsen M.K.,Paludan S.R.
Nat. Immunol.
21
1468-1469
2020
586877
Williams C.G.,Jureka A.S.,Silvas J.A.,Nicolini A.M.,Chvatal S.A.,Carlson-Stevermer J.,Oki J.,Holden K.,Basler C.F.
Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication.
Cell Rep.
36
109479-109479
2021
586878
Wang W.,Li J.,Tan J.,Wang M.,Yang J.,Zhang Z.M.,Li C.,Basnakian A.G.,Tang H.W.,Perrimon N.,Zhou Q.
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
Nat. Commun.
12
476-476
2021
586879
Chen Y.H.,Huang T.Y.,Lin Y.T.,Lin S.Y.,Li W.H.,Hsiao H.J.,Yan R.L.,Tang H.W.,Shen Z.Q.,Chen G.C.,Wu K.P.,Tsai T.F.,Chen R.H.
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism.
Nat. Commun.
12
1322-1322
2021
