Sequence of DXR_PLAF7
EC Number:1.1.1.267
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
1-deoxy-D-xylulose-5-phosphate reductoisomerase
Q8IKG4
Plasmodium falciparum (isolate 3D7)
488
55757
Reaction
2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
Other sequences found for EC No. 1.1.1.267
General information:
Sequence
0 MKKYIYIYFF FITITINDLV INNTSKCVSI ERRKNNAYIN YGIGYNGPDN KITKSRRCKR
60 IKLCKKDLID IGAIKKPINV AIFGSTGSIG TNALNIIREC NKIENVFNVK ALYVNKSVNE
120 LYEQAREFLP EYLCIHDKSV YEELKELVKN IKDYKPIILC GDEGMKEICS SNSIDKIVIG
180 IDSFQGLYST MYAIMNNKIV ALANKESIVS AGFFLKKLLN IHKNAKIIPV DSEHSAIFQC
240 LDNNKVLKTK CLQDNFSKIN NINKIFLCSS GGPFQNLTMD ELKNVTSENA LKHPKWKMGK
300 KITIDSATMM NKGLEVIETH FLFDVDYNDI EVIVHKECII HSCVEFIDKS VISQMYYPDM
360 QIPILYSLTW PDRIKTNLKP LDLAQVSTLT FHKPSLEHFP CIKLAYQAGI KGNFYPTVLN
420 ASNEIANNLF LNNKIKYFDI SSIISQVLES FNSQKVSENS EDLMKQILQI HSWAKDKATD
480 IYNKHNSS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
412025
Gardner M.J.,Hall N.,Fung E.,White O.,Berriman M.,Hyman R.W.,Carlton J.M.,Pain A.,Nelson K.E.,Bowman S.,Paulsen I.T.,James K.D.,Eisen J.A.,Rutherford K.M.,Salzberg S.L.,Craig A.,Kyes S.,Chan M.-S.,Nene V.,Shallom S.J.,Suh B.,Peterson J.,Angiuoli S.,Pertea M.,Allen J.,Selengut J.,Haft D.,Mather M.W.,Vaidya A.B.,Martin D.M.A.,Fairlamb A.H.,Fraunholz M.J.,Roos D.S.,Ralph S.A.,McFadden G.I.,Cummings L.M.,Subramanian G.M.,Mungall C.,Venter J.C.,Carucci D.J.,Hoffman S.L.,Newbold C.,Davis R.W.,Fraser C.M.,Barrell B.G.
Genome sequence of the human malaria parasite Plasmodium falciparum.
Nature
419
498-511
2002
412026
Chofor R.,Sooriyaarachchi S.,Risseeuw M.D.,Bergfors T.,Pouyez J.,Johny C.,Haymond A.,Everaert A.,Dowd C.S.,Maes L.,Coenye T.,Alex A.,Couch R.D.,Jones T.A.,Wouters J.,Mowbray S.L.,Van Calenbergh S.
Synthesis and bioactivity of beta-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
J. Med. Chem.
58
2988-3001
2015
412027
Sooriyaarachchi S.,Chofor R.,Risseeuw M.D.,Bergfors T.,Pouyez J.,Dowd C.S.,Maes L.,Wouters J.,Jones T.A.,Van Calenbergh S.,Mowbray S.L.
Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
ChemMedChem
11
2024-2036
2016
