Sequence of Q83V25_PSEFL
EC Number:4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 4
EC Number:4.1.1.45
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2
Other sequences found for EC No. 4.1.1.45
General information:
Sequence
0 MKKPRIDMHS HFFPRISEQE AAKFDANHAP WLQVSAKGDT GSIMMGKNNF RPVYQALWDP
60 AFRIEEMDAQ GVDVQVTCAT PVMFGYTWEA NKAAQWAERM NDFALEFAAH NPQRIKVLAQ
120 VPLQDLDLAC KEASRAVAAG HLGIQIGNHL GDKDLDDATL EAFLTHCANE DIPILVHPWD
180 MMGGQRMKKW MLPWLVAMPA ETQLAILSLI LSGAFERIPK SLKICFGHGG GSFAFLLGRV
240 DNAWRHRDIV REDCPRPPSE YVDRFFVDSA VFNPGALELL VSVMGEDRVM LGSDYPFPLG
300 EQKIGGLVLS SNLGESAKDK IISGNASKFF NINV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
35575032
Muraki T.,Taki M.,Hasegawa Y.,Iwaki H.,Lau P.C.K.
Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.
Appl. Environ. Microbiol.
69
1564-1572
2003
35575033
Martynowski D.,Eyobo Y.,Li T.,Yang K.,Liu A.,Zhang H.
Crystal structure of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase: insight into the active site and catalytic mechanism of a novel decarboxylation reaction.
Biochemistry
45
10412-10421
2006
35575034
Huo L.,Fielding A.J.,Chen Y.,Li T.,Iwaki H.,Hosler J.P.,Chen L.,Hasegawa Y.,Que L.,Liu A.
Evidence for a dual role of an active site histidine in alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase.
Biochemistry
51
5811-5821
2012
35575035
Huo L.,Davis I.,Chen L.,Liu A.
The power of two: arginine 51 and arginine 239* from a neighboring subunit are essential for catalysis in alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase.
J. Biol. Chem.
288
30862-30871
2013
35575036
Yang Y.,Davis I.,Matsui T.,Rubalcava I.,Liu A.
Quaternary structure of alpha-amino-beta-carboxymuconate--semialdehyde decarboxylase (ACMSD) controls its activity.
J. Biol. Chem.
294
11609-11621
2019
35575037
Yang Y.,Borel T.,de Azambuja F.,Johnson D.,Sorrentino J.P.,Udokwu C.,Davis I.,Liu A.,Altman R.A.
Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway.
J. Med. Chem.
64
797-811
2021
