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Sequence of Q7SIB6_GEOSE

EC Number:2.1.2.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
glycine hydroxymethyltransferase
Q7SIB6
Geobacillus stearothermophilus
419
45656
Reaction
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
Other sequences found for EC No. 2.1.2.1

General information:

Sequence
show sequence in fasta format
  0 MKYLPQQDPQ VFAAIEQERK RQHAKIELIA SENFVSRAVM EAQGSVLTNK YAEGYPGRRY
 60 YGGCEYVDIV EELARERAKQ LFGAEHANVQ PHSGAQANMA VYFTVLEHGD TVLGMNLSHG
120 GHLTHGSPVN FSGVQYNFVA YGVDPETHVI DYDDVREKAR LHRPKLIVAA ASAYPRIIDF
180 AKFREIADEV GAYLMVDMAH IAGLVAAGLH PNPVPYAHFV TTTTHKTLRG PRGGMILCQE
240 QFAKQIDKAI FPGIQGGPLM HVIAAKAVAF GEALQDDFKA YAKRVVDNAK RLASALQNEG
300 FTLVSGGTDN HLLLVDLRPQ QLTGKTAEKV LDEVGITVNK NTIPYDPESP FVTSGIRIGT
360 AAVTTRGFGL EEMDEIAAII GLVLKNVGSE QALEEARQRV AALTDPTSRS AAGTMEFEA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
147720388
Trivedi V.,Gupta A.,Jala V.R.,Saravanan P.,Rao G.S.,Rao N.A.,Savithri H.S.,Subramanya H.S.
Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
J. Biol. Chem.
277
17161-17169
2002
147720389
Bhavani S.,Trivedi V.,Jala V.R.,Subramanya H.S.,Kaul P.,Prakash V.,Appaji Rao N.,Savithri H.S.
Role of Lys-226 in the catalytic mechanism of Bacillus stearothermophilus serine hydroxymethyltransferase--crystal structure and kinetic studies.
Biochemistry
44
6929-6937
2005
147720390
Rajaram V.,Bhavani B.S.,Kaul P.,Prakash V.,Appaji Rao N.,Savithri H.S.,Murthy M.R.
Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory.
FEBS J.
274
4148-4160
2007
147720392
Bhavani B.S.,Rajaram V.,Bisht S.,Kaul P.,Prakash V.,Murthy M.R.,Appaji Rao N.,Savithri H.S.
Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage.
FEBS J.
275
4606-4619
2008
147720393
Pai V.R.,Rajaram V.,Bisht S.,Bhavani B.S.,Rao N.A.,Murthy M.R.,Savithri H.S.
Structural and functional studies of Bacillus stearothermophilus serine hydroxymethyltransferase: the role of Asn(341), Tyr(60) and Phe(351) in tetrahydrofolate binding.
Biochem. J.
418
635-642
2009