Sequence of ROX_NOCFA
EC Number:1.14.13.50
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
2,3,5,6-tetrachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachlorohydroquinone + NADP+ + H2O
Other sequences found for EC No. 1.14.13.50
EC Number:1.14.13.211
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
rifampicin + NAD(P)H + O2 = 2'-N-hydroxyrifampicin + NAD(P)+ + H2O
Other sequences found for EC No. 1.14.13.211
General information:
Sequence
0 MIDVIIAGGG PTGLMLAGEL RLHGVRTVVL EKEPTPNQHS RSRGLHARSI EVMDQRGLLE
60 RFLAHGEQFR VGGFFAGLAA EWPADLDTAH SYVLAIPQVV TERLLTEHAT ELGAEIRRGC
120 EVAGLDQDAD GVTAELADGT RLRARYLVGC DGGRSTVRRL LGVDFPGEPT RVETLLADVR
180 IDVPVETLTA VVAEVRKTQL RFGAVPAGDG FFRLIVPAQG LSADRAAPTL DELKRCLHAT
240 AGTDFGVHSP RWLSRFGDAT RLAERYRTGR VLLAGDAAHI HPPTGGQGLN LGIQDAFNLG
300 WKLAAAIGGW APPDLLDSYH DERHPVAAEV LDNTRAQMTL LSLDPGPRAV RRLMAELVEF
360 PDVNRHLIEK ITAIAVRYDL GDGHDLVGRR LRDIPLTEGR LYERMRGGRG LLLDRTGRLS
420 VSGWSDRVDH LADPGAALDV PAALLRPDGH VAWVGEDQDD LLAHLPRWFG AAT
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
350804
Ishikawa J.,Yamashita A.,Mikami Y.,Hoshino Y.,Kurita H.,Hotta K.,Shiba T.,Hattori M.
The complete genomic sequence of Nocardia farcinica IFM 10152.
Proc. Natl. Acad. Sci. U.S.A.
101
14925-14930
2004
350805
Hoshino Y.,Fujii S.,Shinonaga H.,Arai K.,Saito F.,Fukai T.,Satoh H.,Miyazaki Y.,Ishikawa J.
Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance.
J. Antibiot.
63
23-28
2010
350806
Liu L.K.,Abdelwahab H.,Martin Del Campo J.S.,Mehra-Chaudhary R.,Sobrado P.,Tanner J.J.
The Structure of the Antibiotic Deactivating, N-hydroxylating Rifampicin Monooxygenase.
J. Biol. Chem.
291
21553-21562
2016
350807
Liu L.K.,Dai Y.,Abdelwahab H.,Sobrado P.,Tanner J.J.
Structural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge.
Biochemistry
57
2065-2068
2018
