Sequence of Q59128_PAENI
EC Number:1.5.99.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(S)-nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor
Other sequences found for EC No. 1.5.99.4
General information:
Sequence
0 MTTPSPSDRV EIDVEVNGRR RTVAVDARET LADHLRNDQK LTGIKLGCEH GVCGACTILM
60 DGAAVRSCLT LAAQGDGRSI RTVEDLSDGA LSPLQEAFKR HHALQCGFCT AGFLMSATEL
120 LEANPSPTKE EVIEALSGNL CRCTGYQTIV EAVLDAPGQI GNKNG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
109801593
Brandsch R.,Hinkkanen A.E.,Mauch L.,Nagursky H.,Decker K.
6-hydroxy-D-nicotine oxidase of Arthrobacter oxidans. Gene structure of the flavoenzyme and its relationship to 6-hydroxy-L-nicotine oxidase.
Eur. J. Biochem.
167
315-320
1987
109801594
Grether-Beck S.,Igloi G.L.,Pust S.,Schiltz E.,Decker K.,Brandsch R.
Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans.
Mol. Microbiol.
13
929-936
1994
109801595
Menendez C.,Igloi G.,Henninger H.,Brandsch R.
A pAO1-encoded molybdopterin cofactor gene (moaA) of Arthrobacter nicotinovorans: characterization and site-directed mutagenesis of the encoded protein.
Arch. Microbiol.
164
142-151
1995
109801597
Menendez C.,Otto A.,Igloi G.,Nick P.,Brandsch R.,Schubach B.,Bottcher B.,Brandsch R.
Molybdate-uptake genes and molybdopterin-biosynthesis genes on a bacterial plasmid: characterization of MoeA as a filament-forming protein with adenosinetriphosphatase activity.
Eur. J. Biochem.
250
524-531
1997
109801598
Menendez C.,Igloi G.L.,Brandsch R.
IS1473, a putative insertion sequence identified in the plasmid pAO1 from Arthrobacter nicotinovorans: isolation, characterization, and distribution among Arthrobacter species.
Plasmid
37
35-41
1997
109801599
Baitsch D.,Sandu C.,Brandsch R.,Igloi G.L.
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
J. Bacteriol.
183
5262-5267
2001
109801600
Igloi G.L.,Brandsch R.
Sequence of the 165-kilobase catabolic plasmid pAO1 from Arthrobacter nicotinovorans and identification of a pAO1-dependent nicotine uptake system.
J. Bacteriol.
185
1976-1986
2003
109801601
Sandu C.,Chiribau C.B.,Brandsch R.
Characterization of HdnoR, the transcriptional repressor of the 6-hydroxy-D-nicotine oxidase gene of Arthrobacter nicotinovorans pAO1, and its DNA-binding activity in response to L- and D-nicotine Derivatives.
J. Biol. Chem.
278
51307-51315
2003
109801602
Chiribau CB.,Sandu C.,Fraaije M.,Schiltz E.,Brandsch R.
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
Eur. J. Biochem.
271
4677-4684
2004
109801603
Chiribau CB.,Sandu C.,Igloi G.L.,Brandsch R.
Characterization of PmfR, the transcriptional activator of the pAO1-borne purU-mabO-folD operon of Arthrobacter nicotinovorans.
J. Bacteriol.
187
3062-3070
2005
109801604
Sachelaru P.,Schiltz E.,Igloi G.L.,Brandsch R.
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
J. Bacteriol.
187
8516-8519
2005
109801605
Sachelaru P.,Schiltz E.,Brandsch R.
A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans.
Appl. Environ. Microbiol.
72
5126-5131
2006
109801606
Brandsch R.
Microbiology and biochemistry of nicotine degradation.
Appl. Microbiol. Biotechnol.
69
493-498
2006
109801607
Chiribau CB.,Mihasan M.,Ganas P.,Igloi G.L.,Artenie V.,Brandsch R.
Final steps in the catabolism of nicotine.
FEBS J.
273
1528-1536
2006
109801608
Mihasan M.,Chiribau CB.,Friedrich T.,Artenie V.,Brandsch R.
An NAD(P)H-nicotine blue oxidoreductase is part of the nicotine regulon and may protect Arthrobacter nicotinovorans from oxidative stress during nicotine catabolism.
Appl. Environ. Microbiol.
73
2479-2485
2007
109801609
Ganas P.,Mihasan M.,Igloi GL.,Brandsch R.
A two-component small multidrug resistance pump functions as a metabolic valve during nicotine catabolism by Arthrobacter nicotinovorans.
Microbiology
153
1546-1555
2007
109801610
Cobzaru C.,Ganas P.,Mihasan M.,Schleberger P.,Brandsch R.
Homologous gene clusters of nicotine catabolism, including a new omega-amidase for alpha-ketoglutaramate, in species of three genera of Gram-positive bacteria.
Res. Microbiol.
162
285-291
2011
109801611
Mihasan M.,Brandsch R.
pAO1 of Arthrobacter nicotinovorans and the spread of catabolic traits by horizontal gene transfer in gram-positive soil bacteria.
J. Mol. Evol.
77
22-30
2013
109801612
Mihasan M.,Stefan M.,Hritcu L.,Artenie V.,Brandsch R.
Evidence of a plasmid-encoded oxidative xylose-catabolic pathway in Arthrobacter nicotinovorans pAO1.
Res. Microbiol.
164
22-30
2013
