Sequence of HCDS1_XANP2
EC Number:1.1.1.269
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2-(S)-hydroxypropyl-CoM dehydrogenase
Q56841
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
249
24941
Reaction
(2S)-2-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+
Other sequences found for EC No. 1.1.1.269
General information:
Sequence
0 MLDAEVIAIT GGAAGIGLAV AHAAIRAGAR VALIDRDGAC AQRAAAEFGA AAWGVGADVT
60 DEAAITAAMA GAQRALGPLT GLVNNAGIAG FGSVHATEVE TWSRIMAVNV TGTFLASKAA
120 LFGMLERGRG AIVNFGSVAG LVGIPTMAAY CAAKGAVVNL TRQMAADYSG RGIRVNVVCP
180 GTVAGTDMGR QLLGTDCDPE LEARRLAKYP MGRFGTPEDI AEAAVFLLST KAAFVTGSVL
240 AVDGGMTAI
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1067086
Swaving J.,Weijers C.A.G.M.,van Ooyen A.J.J.,de Bont J.A.M.
Complementation of Xanthobacter Py2 mutants in epoxyalkane degradation; expression and nucleotide sequence of the complementing DNA fragment.
Microbiology
141
477-484
1995
1067088
Allen J.R.,Ensign S.A.
Purification to homogeneity and reconstitution of the individual components of the epoxide carboxylase multiprotein enzyme complex from Xanthobacter strain Py2.
J. Biol. Chem.
272
32121-32128
1997
1067089
Allen J.R.,Clark D.D.,Krum J.G.,Ensign S.A.
A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation.
Proc. Natl. Acad. Sci. U.S.A.
96
8432-8437
1999
1067090
Clark D.D.,Ensign S.A.
Characterization of the 2-[(R)-2-hydroxypropylthio]ethanesulfonate dehydrogenase from Xanthobacter strain Py2: product inhibition, pH dependence of kinetic parameters, site-directed mutagenesis, rapid equilibrium inhibition, and chemical modification.
Biochemistry
41
2727-2740
2002
1067091
Sliwa D.A.,Krishnakumar A.M.,Peters J.W.,Ensign S.A.
Molecular basis for enantioselectivity in the (R)- and (S)-hydroxypropylthioethanesulfonate dehydrogenases, a unique pair of stereoselective short-chain dehydrogenases/reductases involved in aliphatic epoxide carboxylation.
Biochemistry
49
3487-3498
2010
