Sequence of HCDR1_XANP2
EC Number:1.1.1.268
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2-(R)-hydroxypropyl-CoM dehydrogenase
Q56840
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
250
26143
Reaction
2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+
Other sequences found for EC No. 1.1.1.268
General information:
Sequence
0 MSRVAIVTGA SSGNGLAIAT RFLARGDRVA ALDLSAETLE ETARTHWHAY ADKVLRVRAD
60 VADEGDVNAA IAATMEQFGA IDVLVNNAGI TGNSEAGVLH TTPVEQFDKV MAVNVRGIFL
120 GCRAVLPHML LQGAGVIVNI ASVASLVAFP GRSAYTTSKG AVLQLTKSVA VDYAGSGIRC
180 NAVCPGMIET PMTQWRLDQP ELRDQVLARI PQKEIGTAAQ VADAVMFLAG EDATYVNGAA
240 LVMDGAYTAI
Download this sequence
in fasta formatDownload all sequences for 1.1.1.268
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1067076
Swaving J.,Weijers C.A.G.M.,van Ooyen A.J.J.,de Bont J.A.M.
Complementation of Xanthobacter Py2 mutants in epoxyalkane degradation; expression and nucleotide sequence of the complementing DNA fragment.
Microbiology
141
477-484
1995
1067078
Allen J.R.,Ensign S.A.
Purification to homogeneity and reconstitution of the individual components of the epoxide carboxylase multiprotein enzyme complex from Xanthobacter strain Py2.
J. Biol. Chem.
272
32121-32128
1997
1067079
Allen J.R.,Clark D.D.,Krum J.G.,Ensign S.A.
A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation.
Proc. Natl. Acad. Sci. U.S.A.
96
8432-8437
1999
1067080
Clark D.D.,Ensign S.A.
Characterization of the 2-[(R)-2-hydroxypropylthio]ethanesulfonate dehydrogenase from Xanthobacter strain Py2: product inhibition, pH dependence of kinetic parameters, site-directed mutagenesis, rapid equilibrium inhibition, and chemical modification.
Biochemistry
41
2727-2740
2002
1067081
Clark D.D.,Boyd J.M.,Ensign S.A.
The stereoselectivity and catalytic properties of Xanthobacter autotrophicus 2-[(R)-2-Hydroxypropylthio]ethanesulfonate dehydrogenase are controlled by interactions between C-terminal arginine residues and the sulfonate of coenzyme M.
Biochemistry
43
6763-6771
2004
1067082
Sliwa D.A.,Krishnakumar A.M.,Peters J.W.,Ensign S.A.
Molecular basis for enantioselectivity in the (R)- and (S)-hydroxypropylthioethanesulfonate dehydrogenases, a unique pair of stereoselective short-chain dehydrogenases/reductases involved in aliphatic epoxide carboxylation.
Biochemistry
49
3487-3498
2010
1067083
Boyd J.M.,Clark D.D.,Kofoed M.A.,Ensign S.A.
Mechanism of inhibition of aliphatic epoxide carboxylation by the coenzyme M analog 2-bromoethanesulfonate.
J. Biol. Chem.
285
25232-25242
2010
1067085
Krishnakumar A.M.,Nocek B.P.,Clark D.D.,Ensign S.A.,Peters J.W.
Structural basis for stereoselectivity in the (R)- and (S)-hydroxypropylthioethanesulfonate dehydrogenases.
Biochemistry
45
8831-8840
2006
