Sequence of Q4Q5S8_LEIMA

glycylpeptide N-tetradecanoyltransferase

Q4Q5S8

421

48514

102854672

Ivens A.C.,Peacock C.S.,Worthey E.A.,Murphy L.,Aggarwal G.,Berriman M.,Sisk E.,Rajandream M.A.,Adlem E.,Aert R.,Anupama A.,Apostolou Z.,Attipoe P.,Bason N.,Bauser C.,Beck A.,Beverley S.M.,Bianchettin G.,Borzym K.,Bothe G.,Bruschi C.V.,Collins M.,Cadag E.,Ciarloni L.,Clayton C.,Coulson R.M.,Cronin A.,Cruz A.K.,Davies R.M.,De Gaudenzi J.,Dobson D.E.,Duesterhoeft A.,Fazelina G.,Fosker N.,Frasch A.C.,Fraser A.,Fuchs M.,Gabel C.,Goble A.,Goffeau A.,Harris D.,Hertz-Fowler C.,Hilbert H.,Horn D.,Huang Y.,Klages S.,Knights A.,Kube M.,Larke N.,Litvin L.,Lord A.,Louie T.,Marra M.,Masuy D.,Matthews K.,Michaeli S.,Mottram J.C.,Muller-Auer S.,Munden H.,Nelson S.,Norbertczak H.,Oliver K.,O'neil S.,Pentony M.,Pohl T.M.,Price C.,Purnelle B.,Quail M.A.,Rabbinowitsch E.,Reinhardt R.,Rieger M.,Rinta J.,Robben J.,Robertson L.,Ruiz J.C.,Rutter S.,Saunders D.,Schafer M.,Schein J.,Schwartz D.C.,Seeger K.,Seyler A.,Sharp S.,Shin H.,Sivam D.,Squares R.,Squares S.,Tosato V.,Vogt C.,Volckaert G.,Wambutt R.,Warren T.,Wedler H.,Woodward J.,Zhou S.,Zimmermann W.,Smith D.F.,Blackwell J.M.,Stuart K.D.,Barrell B.,Myler P.J.

The genome of the kinetoplastid parasite, Leishmania major.

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Frearson J.A.,Brand S.,McElroy S.P.,Cleghorn L.A.,Smid O.,Stojanovski L.,Price H.P.,Guther M.L.,Torrie L.S.,Robinson D.A.,Hallyburton I.,Mpamhanga C.P.,Brannigan J.A.,Wilkinson A.J.,Hodgkinson M.,Hui R.,Qiu W.,Raimi O.G.,van Aalten D.M.,Brenk R.,Gilbert I.H.,Read K.D.,Fairlamb A.H.,Ferguson M.A.,Smith D.F.,Wyatt P.G.

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Nature

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2010

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Rogers M.B.,Hilley J.D.,Dickens N.J.,Wilkes J.,Bates P.A.,Depledge D.P.,Harris D.,Her Y.,Herzyk P.,Imamura H.,Otto T.D.,Sanders M.,Seeger K.,Dujardin J.C.,Berriman M.,Smith D.F.,Hertz-Fowler C.,Mottram J.C.

Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.

Genome Res.

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2011

102854675

Brand S.,Cleghorn L.A.,McElroy S.P.,Robinson D.A.,Smith V.C.,Hallyburton I.,Harrison J.R.,Norcross N.R.,Spinks D.,Bayliss T.,Norval S.,Stojanovski L.,Torrie L.S.,Frearson J.A.,Brenk R.,Fairlamb A.H.,Ferguson M.A.,Read K.D.,Wyatt P.G.,Gilbert I.H.

Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.

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2012

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Brannigan J.A.,Roberts S.M.,Bell A.S.,Hutton J.A.,Hodgkinson M.R.,Tate E.W.,Leatherbarrow R.J.,Smith D.F.,Wilkinson A.J.

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.

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Hutton J.A.,Goncalves V.,Brannigan J.A.,Paape D.,Wright M.H.,Waugh T.M.,Roberts S.M.,Bell A.S.,Wilkinson A.J.,Smith D.F.,Leatherbarrow R.J.,Tate E.W.

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

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Olaleye T.O.,Brannigan J.A.,Roberts S.M.,Leatherbarrow R.J.,Wilkinson A.J.,Tate E.W.

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites.

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102854679

Robinson D.A.,Wyatt P.G.

Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase.

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Spinks D.,Smith V.,Thompson S.,Robinson D.A.,Luksch T.,Smith A.,Torrie L.S.,McElroy S.,Stojanovski L.,Norval S.,Collie I.T.,Hallyburton I.,Rao B.,Brand S.,Brenk R.,Frearson J.A.,Read K.D.,Wyatt P.G.,Gilbert I.H.

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.

ChemMedChem

10

1821-1836

2015

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Rackham M.D.,Yu Z.,Brannigan J.A.,Heal W.P.,Paape D.,Barker K.V.,Wilkinson A.J.,Smith D.F.,Leatherbarrow R.J.,Tate E.W.

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

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2015

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Goncalves V.,Brannigan J.A.,Laporte A.,Bell A.S.,Roberts S.M.,Wilkinson A.J.,Leatherbarrow R.J.,Tate E.W.

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.

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191-197

2017

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Harrison J.R.,Brand S.,Smith V.,Robinson D.A.,Thompson S.,Smith A.,Davies K.,Mok N.,Torrie L.S.,Collie I.,Hallyburton I.,Norval S.,Simeons F.R.C.,Stojanovski L.,Frearson J.A.,Brenk R.,Wyatt P.G.,Gilbert I.H.,Read K.D.

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

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Kersten C.,Fleischer E.,Kehrein J.,Borek C.,Jaenicke E.,Sotriffer C.,Brenk R.

How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System.

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63

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Bell A.S.,Yu Z.,Hutton J.A.,Wright M.H.,Brannigan J.A.,Paape D.,Roberts S.M.,Sutherell C.L.,Ritzefeld M.,Wilkinson A.J.,Smith D.F.,Leatherbarrow R.J.,Tate E.W.

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.

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2020