Sequence of Q27GS3_ACTS5
EC Number:2.7.1.214
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
C7-cyclitol 7-kinase
Q27GS3
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
492
54195
Reaction
ATP + validone = ADP + validone 7-phosphate
Other sequences found for EC No. 2.7.1.214
General information:
Sequence
0 MTPRPVSTID VSLASLLRTA DWPHEDLRGP GGVRILDEAI LGPSRLLIVA AERNPESRYF
60 VAVLRHDPSR EAVGDAAHDR AVVQAMRERL ALPTAAGHLI VFDGDPAPFR ATRPFDPGWS
120 TNALSLADLD GTLHIHKAYR LVSAATREPH LLRLMHRGGR TQRWAGDYHY VEQPSGRRYP
180 LGLLYAYAEG DSLDLPLRHS IRSMWPALLG GTEPAGAVTA AQRSIAGELP GVGRFLRDFH
240 TELAQRLEPA PTFPVNAYLR ETAERVAALG CRISADERYP RPVREAVVAA LTGELDQATT
300 SAVRVPWPAG PSHGDLHLSH ILRRQTPDGW RLCVIDLSTP APDPADPLGA AQSPWQDLVA
360 LLRGLEIFTA DEFVHQAALR LGADQDDTCR TVLLISAGQT PDTPGWTGSR LTALRRMHDA
420 ASVWAGQVRR MLLSGYADGG EAAEEHPAWR IFRLRRLLHE LDYAYAHDQH YHAAINLRHV
480 LQTYRPPVTG ES
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
227842420
Stratmann A.,Mahmud T.,Lee S.,Distler J.,Floss H.G.,Piepersberg W.
The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
J. Biol. Chem.
274
10889-10896
1999
227842422
Hemker M.,Stratmann A.,Goeke K.,Schroeder W.,Lenz J.,Piepersberg W.,Pape H.
Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. strain SE50.
J. Bacteriol.
183
4484-4492
2001
227842423
Zhang C.,Stratmann A.,Block O.,Brueckner R.,Podeschwa M.,Altenbach H.J.,Wehmeier U.F.,Piepersberg W.
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
J. Biol. Chem.
277
22853-22862
2002
227842424
Zhang C.,Podeschwa M.,Altenbach H.J.,Piepersberg W.,Wehmeier U.F.
The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.
FEBS Lett.
540
47-52
2003
227842425
Brunkhorst C.,Wehmeier U.F.,Piepersberg W.,Schneider E.
The acbH gene of Actinoplanes sp. encodes a solute receptor with binding activities for acarbose and longer homologs.
Res. Microbiol.
156
322-327
2005
