Sequence of DGKZ_HUMAN
EC Number:2.7.1.107
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate
Other sequences found for EC No. 2.7.1.107
General information:
Sequence
0 MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL FGHRKAITKS
60 GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW FETNVSGDFC YVGEQYCVAR
120 MLKSVSRRKC AACKIVVHTP CIEQLEKINF RCKPSFRESG SRNVREPTFV RHHWVHRRRQ
180 DGKCRHCGKG FQQKFTFHSK EIVAISCSWC KQAYHSKVSC FMLQQIEEPC SLGVHAAVVI
240 PPTWILRARR PQNTLKASKK KKRASFKRKS SKKGPEEGRW RPFIIRPTPS PLMKPLLVFV
300 NPKSGGNQGA KIIQSFLWYL NPRQVFDLSQ GGPKEALEMY RKVHNLRILA CGGDGTVGWI
360 LSTLDQLRLK PPPPVAILPL GTGNDLARTL NWGGGYTDEP VSKILSHVEE GNVVQLDRWD
420 LHAEPNPEAG PEDRDEGATD RLPLDVFNNY FSLGFDAHVT LEFHESREAN PEKFNSRFRN
480 KMFYAGTAFS DFLMGSSKDL AKHIRVVCDG MDLTPKIQDL KPQCVVFLNI PRYCAGTMPW
540 GHPGEHHDFE PQRHDDGYLE VIGFTMTSLA ALQVGGHGER LTQCREVVLT TSKAIPVQVD
600 GEPCKLAASR IRIALRNQAT MVQKAKRRSA APLHSDQQPV PEQLRIQVSR VSMHDYEALH
660 YDKEQLKEAS VPLGTVVVPG DSDLELCRAH IERLQQEPDG AGAKSPTCQK LSPKWCFLDA
720 TTASRFYRID RAQEHLNYVT EIAQDEIYIL DPELLGASAR PDLPTPTSPL PTSPCSPTPR
780 SLQGDAAPPQ GEELIEAAKR NDFCKLQELH RAGGDLMHRD EQSRTLLHHA VSTGSKDVVR
840 YLLDHAPPEI LDAVEENGET CLHQAAALGQ RTICHYIVEA GASLMKTDQQ GDTPRQRAEK
900 AQDTELAAYL ENRQHYQMIQ REDQETAV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
662747
Bunting M.,Tang W.,Zimmerman G.A.,McIntyre T.M.,Prescott S.M.
Molecular cloning and characterization of a novel human diacylglycerol kinase zeta.
J. Biol. Chem.
271
10230-10236
1996
662748
Ding L.,Bunting M.,Topham M.K.,McIntyre T.M.,Zimmerman G.A.,Prescott S.M.
Alternative splicing of the human diacylglycerol kinase zeta gene in muscle.
Proc. Natl. Acad. Sci. U.S.A.
94
5519-5524
1997
662749
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
662751
Taylor T.D.,Noguchi H.,Totoki Y.,Toyoda A.,Kuroki Y.,Dewar K.,Lloyd C.,Itoh T.,Takeda T.,Kim D.-W.,She X.,Barlow K.F.,Bloom T.,Bruford E.,Chang J.L.,Cuomo C.A.,Eichler E.,FitzGerald M.G.,Jaffe D.B.,LaButti K.,Nicol R.,Park H.-S.,Seaman C.,Sougnez C.,Yang X.,Zimmer A.R.,Zody M.C.,Birren B.W.,Nusbaum C.,Fujiyama A.,Hattori M.,Rogers J.,Lander E.S.,Sakaki Y.
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Nature
440
497-500
2006
662753
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
662754
Topham M.K.,Bunting M.,Zimmerman G.A.,McIntyre T.M.,Blackshear P.J.,Prescott S.M.
Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.
Nature
394
697-700
1998
662755
Hogan A.,Shepherd L.,Chabot J.,Quenneville S.,Prescott S.M.,Topham M.K.,Gee S.H.
Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.
J. Biol. Chem.
276
26526-26533
2001
662756
Topham M.K.,Prescott S.M.
Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.
J. Cell Biol.
152
1135-1143
2001
662757
Epand R.M.,Kam A.,Bridgelal N.,Saiga A.,Topham M.K.
The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol.
Biochemistry
43
14778-14783
2004
662758
Luo B.,Prescott S.M.,Topham M.K.
Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism.
Cell. Signal.
16
891-897
2004
662759
Epand R.M.,Shulga Y.V.,Timmons H.C.,Perri A.L.,Belani J.D.,Perinpanathan K.,Johnson-McIntire L.B.,Bajjalieh S.,Dicu A.O.,Elias C.,Rychnovsky S.D.,Topham M.K.
Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.
Biochemistry
46
14225-14231
2007
662760
Rincon E.,Santos T.,Avila-Flores A.,Albar J.P.,Lalioti V.,Lei C.,Hong W.,Merida I.
Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling.
Mol. Cell. Proteomics
6
1073-1087
2007
662761
Lung M.,Shulga Y.V.,Ivanova P.T.,Myers D.S.,Milne S.B.,Brown H.A.,Topham M.K.,Epand R.M.
Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol.
J. Biol. Chem.
284
31062-31073
2009
662762
Shulga Y.V.,Topham M.K.,Epand R.M.
Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle.
FEBS Lett.
585
4025-4028
2011
662763
Gellett A.M.,Kharel Y.,Sunkara M.,Morris A.J.,Lynch K.R.
Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.
Biochem. Biophys. Res. Commun.
422
758-763
2012
662764
Sato M.,Liu K.,Sasaki S.,Kunii N.,Sakai H.,Mizuno H.,Saga H.,Sakane F.
Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.
Pharmacology
92
99-107
2013
662765
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
662766
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
