Sequence of ITPK1_HUMAN
EC Number:2.7.1.134
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
Other sequences found for EC No. 2.7.1.134
EC Number:2.7.1.159
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
Other sequences found for EC No. 2.7.1.159
General information:
Sequence
0 MQTFLKGKRV GYWLSEKKIK KLNFQAFAEL CRKRGMEVVQ LNLSRPIEEQ GPLDVIIHKL
60 TDVILEADQN DSQSLELVHR FQEYIDAHPE TIVLDPLPAI RTLLDRSKSY ELIRKIEAYM
120 EDDRICSPPF MELTSLCGDD TMRLLEKNGL TFPFICKTRV AHGTNSHEMA IVFNQEGLNA
180 IQPPCVVQNF INHNAVLYKV FVVGESYTVV QRPSLKNFSA GTSDRESIFF NSHNVSKPES
240 SSVLTELDKI EGVFERPSDE VIRELSRALR QALGVSLFGI DIIINNQTGQ HAVIDINAFP
300 GYEGVSEFFT DLLNHIATVL QGQSTAMAAT GDVALLRHSK LLAEPAGGLV GERTCSASPG
360 CCGSMMGQDA PWKAEADAGG TAKLPHQRLG CNAGVSPSFQ QHCVASLATK ASSQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1074405
Wilson M.P.,Majerus P.W.
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.
J. Biol. Chem.
271
11904-11910
1996
1074406
Yang X.,Shears S.B.
Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.
Biochem. J.
351
551-555
2000
1074407
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1074408
Wilson M.P.,Sun Y.,Cao L.,Majerus P.W.
Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.
J. Biol. Chem.
276
40998-41004
2001
1074409
Ho M.W.Y.,Yang X.,Carew M.A.,Zhang T.,Hua L.,Kwon Y.-U.,Chung S.-K.,Adelt S.,Vogel G.,Riley A.M.,Potter B.V.L.,Shears S.B.
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.
Curr. Biol.
12
477-482
2002
1074410
Sun Y.,Wilson M.P.,Majerus P.W.
Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.
J. Biol. Chem.
277
45759-45764
2002
1074411
Sun Y.,Mochizuki Y.,Majerus P.W.
Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.
J. Biol. Chem.
278
43645-43653
2003
1074412
Qian X.,Mitchell J.,Wei S.J.,Williams J.,Petrovich R.M.,Shears S.B.
The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase.
Biochem. J.
389
389-395
2005
1074413
Miller G.J.,Wilson M.P.,Majerus P.W.,Hurley J.H.
Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
Mol. Cell
18
201-212
2005
1074414
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1074415
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
1074416
Zhang C.,Majerus P.W.,Wilson M.P.
Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation.
Proc. Natl. Acad. Sci. U.S.A.
109
2290-2295
2012
1074417
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
1074418
Dovey C.M.,Diep J.,Clarke B.P.,Hale A.T.,McNamara D.E.,Guo H.,Brown N.W. Jr.,Cao J.Y.,Grace C.R.,Gough P.J.,Bertin J.,Dixon S.J.,Fiedler D.,Mocarski E.S.,Kaiser W.J.,Moldoveanu T.,York J.D.,Carette J.E.
MLKL requires the inositol phosphate code to execute necroptosis.
Mol. Cell
70
936-948
2018
1074419
Chamberlain P.P.,Qian X.,Stiles A.R.,Cho J.,Jones D.H.,Lesley S.A.,Grabau E.A.,Shears S.B.,Spraggon G.
Integration of inositol phosphate signaling pathways via human ITPK1.
J. Biol. Chem.
282
28117-28125
2007
