Sequence of HDAC1_HUMAN
EC Number:3.5.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 3.5.1
EC Number:3.5.1.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Other sequences found for EC No. 3.5.1.98
General information:
Sequence
0 MAQTQGTRRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN
60 AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS
120 AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG
180 DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI
240 FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
300 GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE
360 KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEDD PDKRISICSS DKRIACEEEF
420 SDSEEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK
480 LA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1067289
Taunton J.,Hassig C.A.,Schreiber S.L.
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
Science
272
408-411
1996
1067290
Furukawa Y.,Kawakami T.,Sudo K.,Inazawa J.,Matsumine A.,Akiyama T.,Nakamura Y.
Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae.
Cytogenet. Cell Genet.
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1067291
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
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1067292
Sparrow D.B.,Miska E.A.,Langley E.,Reynaud-Deonauth S.,Kotecha S.,Towers N.,Spohr G.,Kouzarides T.,Mohun T.J.
MEF-2 function is modified by a novel co-repressor, MITR.
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Huynh K.D.,Fischle W.,Verdin E.,Bardwell V.J.
BCoR, a novel corepressor involved in BCL-6 repression.
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2000
1067294
Cai R.L.,Yan-Neale Y.,Cueto M.A.,Xu H.,Cohen D.
HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.
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Wei L.-N.,Hu X.,Chandra D.,Seto E.,Farooqui M.
Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing.
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Li H.,Leo C.,Zhu J.,Wu X.,O'Neil J.,Park E.-J.,Chen J.D.
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2000
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Zhou X.,Richon V.M.,Rifkind R.A.,Marks P.A.
Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5.
Proc. Natl. Acad. Sci. U.S.A.
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2000
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Pflum M.K.H.,Tong J.K.,Lane W.S.,Schreiber S.L.
Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.
J. Biol. Chem.
276
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2001
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Shi Y.,Downes M.,Xie W.,Kao H.-Y.,Ordentlich P.,Tsai C.-C.,Hon M.,Evans R.M.
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.
Genes Dev.
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1140-1151
2001
1067300
Humphrey G.W.,Wang Y.,Russanova V.R.,Hirai T.,Qin J.,Nakatani Y.,Howard B.H.
Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.
J. Biol. Chem.
276
6817-6824
2001
1067301
Melhuish T.A.,Gallo C.M.,Wotton D.
TGIF2 interacts with histone deacetylase 1 and represses transcription.
J. Biol. Chem.
276
32109-32114
2001
1067302
Amann J.M.,Nip J.,Strom D.K.,Lutterbach B.,Harada H.,Lenny N.,Downing J.R.,Meyers S.,Hiebert S.W.
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Mol. Cell. Biol.
21
6470-6483
2001
1067303
Kirsh O.,Seeler J.-S.,Pichler A.,Gast A.,Mueller S.,Miska E.,Mathieu M.,Harel-Bellan A.,Kouzarides T.,Melchior F.,Dejean A.
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
EMBO J.
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2682-2691
2002
1067304
David G.,Neptune M.A.,DePinho R.A.
SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.
J. Biol. Chem.
277
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2002
1067305
Bhakat K.K.,Izumi T.,Yang S.H.,Hazra T.K.,Mitra S.
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
EMBO J.
22
6299-6309
2003
1067306
Wysocka J.,Myers M.P.,Laherty C.D.,Eisenman R.N.,Herr W.
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.
Genes Dev.
17
896-911
2003
1067307
Hakimi M.-A.,Dong Y.,Lane W.S.,Speicher D.W.,Shiekhattar R.
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.
J. Biol. Chem.
278
7234-7239
2003
1067308
Ammanamanchi S.,Freeman J.W.,Brattain M.G.
Acetylated SP3 is a transcriptional activator.
J. Biol. Chem.
278
35775-35780
2003
1067309
Ding Z.,Gillespie L.L.,Paterno G.D.
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.
Mol. Cell. Biol.
23
250-258
2003
1067310
Fleischer T.C.,Yun U.J.,Ayer D.E.
Identification and characterization of three new components of the mSin3A corepressor complex.
Mol. Cell. Biol.
23
3456-3467
2003
1067311
Colombo R.,Draetta G.F.,Chiocca S.
Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein.
Oncogene
22
2541-2547
2003
1067312
Nikolaev A.Y.,Papanikolaou N.A.,Li M.,Qin J.,Gu W.
Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex.
Biochem. Biophys. Res. Commun.
323
1216-1222
2004
1067313
Fujita N.,Jaye D.L.,Geigerman C.,Akyildiz A.,Mooney M.R.,Boss J.M.,Wade P.A.
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.
Cell
119
75-86
2004
1067314
Zhao Q.,Cumming H.,Cerruti L.,Cunningham J.M.,Jane S.M.
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
J. Biol. Chem.
279
41477-41486
2004
1067315
Cheng J.,Wang D.,Wang Z.,Yeh E.T.H.
SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.
Mol. Cell. Biol.
24
6021-6028
2004
1067316
Unoki M.,Nishidate T.,Nakamura Y.
ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.
Oncogene
23
7601-7610
2004
1067317
Ahringer J.
NuRD and SIN3 histone deacetylase complexes in development.
Trends Genet.
16
351-356
2000
1067318
Gray S.G.,Iglesias A.H.,Lizcano F.,Villanueva R.,Camelo S.,Jingu H.,Teh B.T.,Koibuchi N.,Chin W.W.,Kokkotou E.,Dangond F.
Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.
J. Biol. Chem.
280
28507-28518
2005
1067319
Rampalli S.,Pavithra L.,Bhatt A.,Kundu T.K.,Chattopadhyay S.
Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.
Mol. Cell. Biol.
25
8415-8429
2005
1067320
Liu W.D.,Wang H.W.,Muguira M.,Breslin M.B.,Lan M.S.
INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.
Biochem. J.
397
169-177
2006
1067321
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
1067322
Qiu Y.,Zhao Y.,Becker M.,John S.,Parekh B.S.,Huang S.,Hendarwanto A.,Martinez E.D.,Chen Y.,Lu H.,Adkins N.L.,Stavreva D.A.,Wiench M.,Georgel P.T.,Schiltz R.L.,Hager G.L.
HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.
Mol. Cell
22
669-679
2006
1067323
Hung J.J.,Wang Y.T.,Chang W.C.
Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.
Mol. Cell. Biol.
26
1770-1785
2006
1067324
Liu Y.,Smith P.W.,Jones D.R.
Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis.
Mol. Cell. Biol.
26
8683-8696
2006
1067325
Viiri K.M.,Korkeamaeki H.,Kukkonen M.K.,Nieminen L.K.,Lindfors K.,Peterson P.,Maeki M.,Kainulainen H.,Lohi O.
SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.
Nucleic Acids Res.
34
3288-3298
2006
1067326
Kurita M.,Suzuki H.,Kawano Y.,Aiso S.,Matsuoka M.
CR/periphilin is a transcriptional co-repressor involved in cell cycle progression.
Biochem. Biophys. Res. Commun.
364
930-936
2007
1067327
Giorgianni F.,Zhao Y.,Desiderio D.M.,Beranova-Giorgianni S.
Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
Electrophoresis
28
2027-2034
2007
1067328
Wooten-Blanks L.G.,Song P.,Senkal C.E.,Ogretmen B.
Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.
FASEB J.
21
3386-3397
2007
1067329
Barrett A.,Santangelo S.,Tan K.,Catchpole S.,Roberts K.,Spencer-Dene B.,Hall D.,Scibetta A.,Burchell J.,Verdin E.,Freemont P.,Taylor-Papadimitriou J.
Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases.
Int. J. Cancer
121
265-275
2007
1067330
Wang C.,Rauscher F.J. III,Cress W.D.,Chen J.
Regulation of E2F1 function by the nuclear corepressor KAP1.
J. Biol. Chem.
282
29902-29909
2007
1067331
Ohoka N.,Hattori T.,Kitagawa M.,Onozaki K.,Hayashi H.
Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.
J. Biol. Chem.
282
35687-35694
2007
1067332
Valls E.,Blanco-Garcia N.,Aquizu N.,Piedra D.,Estaras C.,de la Cruz X.,Martinez-Balbas M.A.
Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation.
Nucleic Acids Res.
35
1958-1968
2007
1067333
Jacobs A.M.,Nicol S.M.,Hislop R.G.,Jaffray E.G.,Hay R.T.,Fuller-Pace F.V.
SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.
Oncogene
26
5866-5876
2007
1067334
Wang J.,Liu N.,Liu Z.,Li Y.,Song C.,Yuan H.,Li Y.Y.,Zhao X.,Lu H.
The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.
Biochim. Biophys. Acta
1783
224-236
2008
1067335
Iwamoto F.,Stadler M.,Chalupnikova K.,Oakeley E.,Nagamine Y.
Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.
Exp. Cell Res.
314
1378-1391
2008
1067336
Pham L.V.,Zhou H.J.,Lin-Lee Y.C.,Tamayo A.T.,Yoshimura L.C.,Fu L.,Darnay B.G.,Ford R.J.
Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification.
J. Biol. Chem.
283
5081-5089
2008
1067337
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
1067338
Mulligan P.,Westbrook T.F.,Ottinger M.,Pavlova N.,Chang B.,Macia E.,Shi Y.J.,Barretina J.,Liu J.,Howley P.M.,Elledge S.J.,Shi Y.
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
Mol. Cell
32
718-726
2008
1067339
Rathert P.,Dhayalan A.,Murakami M.,Zhang X.,Tamas R.,Jurkowska R.,Komatsu Y.,Shinkai Y.,Cheng X.,Jeltsch A.
Protein lysine methyltransferase G9a acts on non-histone targets.
Nat. Chem. Biol.
4
344-346
2008
1067340
Qiu Z.,Ghosh A.
A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression.
Neuron
60
775-787
2008
1067341
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
1067342
Han G.,Ye M.,Zhou H.,Jiang X.,Feng S.,Jiang X.,Tian R.,Wan D.,Zou H.,Gu J.
Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
Proteomics
8
1346-1361
2008
1067343
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
1067344
Takahata M.,Inoue Y.,Tsuda H.,Imoto I.,Koinuma D.,Hayashi M.,Ichikura T.,Yamori T.,Nagasaki K.,Yoshida M.,Matsuoka M.,Morishita K.,Yuki K.,Hanyu A.,Miyazawa K.,Inazawa J.,Miyazono K.,Imamura T.
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.
J. Biol. Chem.
284
3334-3344
2009
1067345
Rashid S.,Pilecka I.,Torun A.,Olchowik M.,Bielinska B.,Miaczynska M.
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
J. Biol. Chem.
284
18115-18128
2009
1067346
Kajiwara Y.,Akram A.,Katsel P.,Haroutunian V.,Schmeidler J.,Beecham G.,Haines J.L.,Pericak-Vance M.A.,Buxbaum J.D.
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.
PLoS ONE
4
0-0
2009
1067347
Oh Y.M.,Kwon Y.E.,Kim J.M.,Bae S.J.,Lee B.K.,Yoo S.J.,Chung C.H.,Deshaies R.J.,Seol J.H.
Chfr is linked to tumour metastasis through the downregulation of HDAC1.
Nat. Cell Biol.
11
295-302
2009
1067348
Hait N.C.,Allegood J.,Maceyka M.,Strub G.M.,Harikumar K.B.,Singh S.K.,Luo C.,Marmorstein R.,Kordula T.,Milstien S.,Spiegel S.
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Science
325
1254-1257
2009
1067349
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
1067350
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
1067351
Chini C.C.,Escande C.,Nin V.,Chini E.N.
HDAC3 is negatively regulated by the nuclear protein DBC1.
J. Biol. Chem.
285
40830-40837
2010
1067352
Canettieri G.,Di Marcotullio L.,Greco A.,Coni S.,Antonucci L.,Infante P.,Pietrosanti L.,De Smaele E.,Ferretti E.,Miele E.,Pelloni M.,De Simone G.,Pedone E.M.,Gallinari P.,Giorgi A.,Steinkuhler C.,Vitagliano L.,Pedone C.,Schinin M.E.,Screpanti I.,Gulino A.
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.
Nat. Cell Biol.
12
132-142
2010
1067353
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
1067354
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1067355
Rowbotham S.P.,Barki L.,Neves-Costa A.,Santos F.,Dean W.,Hawkes N.,Choudhary P.,Will W.R.,Webster J.,Oxley D.,Green C.M.,Varga-Weisz P.,Mermoud J.E.
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
Mol. Cell
42
285-296
2011
1067356
Hong Y.,Xing X.,Li S.,Bi H.,Yang C.,Zhao F.,Liu Y.,Ao X.,Chang A.K.,Wu H.
SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.
PLoS ONE
6
0-0
2011
1067357
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
1067358
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
1067359
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
1067360
Hendriks I.A.,D'Souza R.C.,Yang B.,Verlaan-de Vries M.,Mann M.,Vertegaal A.C.
Uncovering global SUMOylation signaling networks in a site-specific manner.
Nat. Struct. Mol. Biol.
21
927-936
2014
1067361
Yang Y.,Cui J.,Xue F.,Zhang C.,Mei Z.,Wang Y.,Bi M.,Shan D.,Meredith A.,Li H.,Xu Z.Q.
Pokemon (FBI-1) interacts with Smad4 to repress TGF-beta-induced transcriptional responses.
Biochim. Biophys. Acta
1849
270-281
2015
1067362
Hendriks I.A.,Treffers L.W.,Verlaan-de Vries M.,Olsen J.V.,Vertegaal A.C.
SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
Cell Rep.
10
1778-1791
2015
1067363
Xiao Z.,Chang J.G.,Hendriks I.A.,Sigurdsson J.O.,Olsen J.V.,Vertegaal A.C.
System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
Mol. Cell. Proteomics
14
1419-1434
2015
1067364
Itoh T.,Fairall L.,Muskett F.W.,Milano C.P.,Watson P.J.,Arnaudo N.,Saleh A.,Millard C.J.,El-Mezgueldi M.,Martino F.,Schwabe J.W.
Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.
Nucleic Acids Res.
43
2033-2044
2015
1067365
Nicolai S.,Filippi S.,Caputo M.,Cipak L.,Gregan J.,Ammerer G.,Frontini M.,Willems D.,Prantera G.,Balajee A.S.,Proietti-De-Santis L.
Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.
PLoS ONE
10
0-0
2015
1067366
Weiss K.,Terhal P.A.,Cohen L.,Bruccoleri M.,Irving M.,Martinez A.F.,Rosenfeld J.A.,Machol K.,Yang Y.,Liu P.,Walkiewicz M.,Beuten J.,Gomez-Ospina N.,Haude K.,Fong C.T.,Enns G.M.,Bernstein J.A.,Fan J.,Gotway G.,Ghorbani M.,van Gassen K.,Monroe G.R.,van Haaften G.,Basel-Vanagaite L.,Yang X.J.,Campeau P.M.,Muenke M.
De novo mutations in CHD4, an ATP-dependent chromatin remodeler gene, cause an intellectual disability syndrome with distinctive dysmorphisms.
Am. J. Hum. Genet.
99
934-941
2016
1067367
Wei W.,Liu X.,Chen J.,Gao S.,Lu L.,Zhang H.,Ding G.,Wang Z.,Chen Z.,Shi T.,Li J.,Yu J.,Wong J.
Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.
Cell Res.
27
898-915
2017
1067368
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
1067369
Olson H.E.,Jean-Marcais N.,Yang E.,Heron D.,Tatton-Brown K.,van der Zwaag P.A.,Bijlsma E.K.,Krock B.L.,Backer E.,Kamsteeg E.J.,Sinnema M.,Reijnders M.R.F.,Bearden D.,Begtrup A.,Telegrafi A.,Lunsing R.J.,Burglen L.,Lesca G.,Cho M.T.,Smith L.A.,Sheidley B.R.,Moufawad El Achkar C.,Pearl P.L.,Poduri A.,Skraban C.M.,Tarpinian J.,Nesbitt A.I.,Fransen van de Putte D.E.,Ruivenkamp C.A.L.,Rump P.,Chatron N.,Sabatier I.,De Bellescize J.,Guibaud L.,Sweetser D.A.,Waxler J.L.,Wierenga K.J.,Donadieu J.,Narayanan V.,Ramsey K.M.,Nava C.,Riviere J.B.,Vitobello A.,Tran Mau-Them F.,Philippe C.,Bruel A.L.,Duffourd Y.,Thomas L.,Lelieveld S.H.,Schuurs-Hoeijmakers J.,Brunner H.G.,Keren B.,Thevenon J.,Faivre L.,Thomas G.,Thauvin-Robinet C.
A recurrent de novo PACS2 heterozygous missense variant causes neonatal-onset developmental epileptic encephalopathy, facial dysmorphism, and cerebellar dysgenesis.
Am. J. Hum. Genet.
102
995-1007
2018
1067370
Zhu Y.,Wang G.Z.,Cingoez O.,Goff S.P.
NP220 mediates silencing of unintegrated retroviral DNA.
Nature
564
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