Sequence of MTAP_HUMAN
EC Number:2.4.2.28
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
Other sequences found for EC No. 2.4.2.28
General information:
Sequence
0 MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR
60 HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR
120 PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR
180 AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL
240 KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
572372
Olopade O.I.,Pomykala H.M.,Hagos F.,Sveen L.W.,Espinosa R. III,Dreyling M.H.,Gursky S.,Stadler W.M.,le Beau M.M.,Bohlander S.K.
Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.
Proc. Natl. Acad. Sci. U.S.A.
92
6489-6493
1995
572373
Nobori T.,Takabayashi K.,Tran P.,Orvis L.,Batova A.,Yu A.L.,Carson D.A.
Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.
Proc. Natl. Acad. Sci. U.S.A.
93
6203-6208
1996
572374
Camacho-Vanegas O.,Camacho S.C.,Till J.,Miranda-Lorenzo I.,Terzo E.,Ramirez M.C.,Schramm V.,Cordovano G.,Watts G.,Mehta S.,Kimonis V.,Hoch B.,Philibert K.D.,Raabe C.A.,Bishop D.F.,Glucksman M.J.,Martignetti J.A.
Primate genome gain and loss: a bone dysplasia, muscular dystrophy, and bone cancer syndrome resulting from mutated retroviral-derived MTAP transcripts.
Am. J. Hum. Genet.
90
614-627
2012
572376
Humphray S.J.,Oliver K.,Hunt A.R.,Plumb R.W.,Loveland J.E.,Howe K.L.,Andrews T.D.,Searle S.,Hunt S.E.,Scott C.E.,Jones M.C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Ashwell R.I.S.,Babbage A.K.,Babbage S.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beasley H.,Beasley O.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Chen Y.,Clarke G.,Clark S.Y.,Clee C.M.,Clegg S.,Collier R.E.,Corby N.,Crosier M.,Cummings A.T.,Davies J.,Dhami P.,Dunn M.,Dutta I.,Dyer L.W.,Earthrowl M.E.,Faulkner L.,Fleming C.J.,Frankish A.,Frankland J.A.,French L.,Fricker D.G.,Garner P.,Garnett J.,Ghori J.,Gilbert J.G.R.,Glison C.,Grafham D.V.,Gribble S.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Guy J.,Hall R.E.,Hammond S.,Harley J.L.,Harrison E.S.I.,Hart E.A.,Heath P.D.,Henderson C.D.,Hopkins B.L.,Howard P.J.,Howden P.J.,Huckle E.,Johnson C.,Johnson D.,Joy A.A.,Kay M.,Keenan S.,Kershaw J.K.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.,Lloyd D.M.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,McLaren S.,McLay K.E.,McMurray A.,Milne S.,Nickerson T.,Nisbett J.,Nordsiek G.,Pearce A.V.,Peck A.I.,Porter K.M.,Pandian R.,Pelan S.,Phillimore B.,Povey S.,Ramsey Y.,Rand V.,Scharfe M.,Sehra H.K.,Shownkeen R.,Sims S.K.,Skuce C.D.,Smith M.,Steward C.A.,Swarbreck D.,Sycamore N.,Tester J.,Thorpe A.,Tracey A.,Tromans A.,Thomas D.W.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Williams S.A.,Wilming L.,Wray P.W.,Young L.,Ashurst J.L.,Coulson A.,Blocker H.,Durbin R.M.,Sulston J.E.,Hubbard T.,Jackson M.J.,Bentley D.R.,Beck S.,Rogers J.,Dunham I.
DNA sequence and analysis of human chromosome 9.
Nature
429
369-374
2004
572378
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
572379
Della Ragione F.,Carteni-Farina M.,Gragnaniello V.,Schettino M.I.,Zappia V.
Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta.
J. Biol. Chem.
261
12324-12329
1986
572380
Ragione F.D.,Takabayashi K.,Mastropietro S.,Mercurio C.,Oliva A.,Russo G.L.,Pietra V.D.,Borriello A.,Nobori T.,Carson D.A.,Zappia V.
Purification and characterization of recombinant human 5'-methylthioadenosine phosphorylase: definite identification of coding cDNA.
Biochem. Biophys. Res. Commun.
223
514-519
1996
572381
Garcia-Castellano J.M.,Villanueva A.,Healey J.H.,Sowers R.,Cordon-Cardo C.,Huvos A.,Bertino J.R.,Meyers P.,Gorlick R.
Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma.
Clin. Cancer Res.
8
782-787
2002
572382
Miyazaki S.,Nishioka J.,Shiraishi T.,Matsumine A.,Uchida A.,Nobori T.
Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients.
Int. J. Oncol.
31
1069-1076
2007
572383
Stevens A.P.,Spangler B.,Wallner S.,Kreutz M.,Dettmer K.,Oefner P.J.,Bosserhoff A.K.
Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma.
J. Cell. Biochem.
106
210-219
2009
572384
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
572385
Kim J.,Kim M.A.,Min S.Y.,Jee C.D.,Lee H.E.,Kim W.H.
Downregulation of methylthioadenosine phosphorylase by homozygous deletion in gastric carcinoma.
Genes Chromosomes Cancer
50
421-433
2011
572386
Appleby T.C.,Erion M.D.,Ealick S.E.
The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7-A resolution provides insights into substrate binding and catalysis.
Structure
7
629-641
1999
572387
Lee J.E.,Settembre E.C.,Cornell K.A.,Riscoe M.K.,Sufrin J.R.,Ealick S.E.,Howell P.L.
Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.
Biochemistry
43
5159-5169
2004
572388
Singh V.,Shi W.,Evans G.B.,Tyler P.C.,Furneaux R.H.,Almo S.C.,Schramm V.L.
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
Biochemistry
43
9-18
2004
572389
Bade-Doding C.,Theodossis A.,Gras S.,Kjer-Nielsen L.,Eiz-Vesper B.,Seltsam A.,Huyton T.,Rossjohn J.,McCluskey J.,Blasczyk R.
The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.
Haematologica
96
110-118
2011
